Guest guest Posted March 22, 2006 Report Share Posted March 22, 2006 In einer eMail vom 22.03.2006 20:57:14 Westeuropäische Normalzeit schreibt rboylern@...: AP - 18 minutes ago NEW YORK - Scientists say they've found a reason bird flu isn't spreading easily from person to person: The virus concentrates itself too deep in the respiratory tract to be spewed out by coughing and sneezing. But the virus could change that behavior by genetic mutation, taking a step toward unleashing a worldwide outbreak of lethal flu. Experts said the new finding doesn't indicate how likely such a pandemic is. The virus may also need other mutations to take off in the human population, they said. Still, the work suggests a particular sign to watch for in new virus samples to help gauge the danger to humans. it may infect the lungs first but later in the desease almost any organ is infected as I read. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 22, 2006 Report Share Posted March 22, 2006 >Do you recall where you heard that? >>it may infect the lungs first but later in the desease almost any organ is infected >>as I read. probably Fluwiki forum.Or curevents. I remember a discussion about why Relenza therapy should switch to Tamiflu later, because Relenza only protects the lungs. I can search for it, if it's important I just read in the recent Osterholm interview too that liver,kidney...would fail Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 22, 2006 Report Share Posted March 22, 2006 Do you recall where you heard that? sterten@... wrote: In einer eMail vom 22.03.2006 20:57:14 Westeuropäische Normalzeit schreibt rboylern@...: AP - 18 minutes ago NEW YORK - Scientists say they've found a reason bird flu isn't spreading easily from person to person: The virus concentrates itself too deep in the respiratory tract to be spewed out by coughing and sneezing. But the virus could change that behavior by genetic mutation, taking a step toward unleashing a worldwide outbreak of lethal flu. Experts said the new finding doesn't indicate how likely such a pandemic is. The virus may also need other mutations to take off in the human population, they said. Still, the work suggests a particular sign to watch for in new virus samples to help gauge the danger to humans. it may infect the lungs first but later in the desease almost any organ is infected as I read. . Be who you are and say what you feel, because those who mind don't matter and those who matter don't mind. -Dr.Seuss . It don't mean a thing if it ain't got that swing. - Duke Ellington . Never place a period where God has placed a comma. - Gracie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2006 Report Share Posted March 23, 2006 In einer eMail vom 24.03.2006 00:41:53 Westeuropäische Normalzeit schreibt darkdaysarecoming@...: H5N1 does not infect or live anywhere but in thepulminary system. J.H.Beigel et.al. NEnglJMed,353,1374(Sep29,2005) showed H5N1 in human intestine Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2006 Report Share Posted March 23, 2006 That is an inncorrect statement. H5N1 does not infect or live anywhere but in the pulminary system. Organ failure is cause by what is called the Cytokine Storm, during which the body is attcked by its' own overreacting immune system. As it is nowadays, there is a web page for everything. Read this: http://cytokinestorm.com/ for a very deatil explaination. --- sterten@... wrote: > > In einer eMail vom 22.03.2006 20:57:14 > Westeuropäische Normalzeit schreibt > rboylern@...: > > AP - 18 minutes ago > NEW YORK - Scientists say they've found a reason > bird flu isn't spreading > easily from person to person: The virus concentrates > itself too deep in the > respiratory tract to be spewed out by coughing and > sneezing. But the virus could > change that behavior by genetic mutation, taking a > step toward unleashing a > worldwide outbreak of lethal flu. Experts said the > new finding doesn't > indicate how likely such a pandemic is. The virus > may also need other mutations to > take off in the human population, they said. Still, > the work suggests a > particular sign to watch for in new virus samples > to help gauge the danger to > humans. > > > > > > it may infect the lungs first but later in the > desease almost any organ is > infected > as I read. > __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2006 Report Share Posted March 23, 2006 In einer eMail vom 24.03.2006 02:34:36 Westeuropäische Normalzeit schreibt darkdaysarecoming@...: Yes, the intesines also, sorry. But it is not whatcauses overall organ failure. It is linked to diarrehahowever. hmm, I read: --------------------------------- What makes them so similar is that they both cause this cytokine storm phenomenon. CP: Which essentially results in a person's drowning in his or her own blood as it fills the lungs, right? Osterholm: It's even worse than that. You get that kind of leakage, yes, but it also goes in and begins to shut down all your vital organs. It's a domino effect. Your kidneys go down, then your liver goes down, you have all this destruction through necrosis of your lungs and your internal organs. Everything goes. ------------------------------------------ so, yes, that was about cytokine storm. So, when there is no c.s., i.e. in the elderly, then only the lungs are affected and Relenza might be enough ? BTW, here is the link to the journal article youcites:http://content.nejm.org/cgi/content/full/353/13/1374 thanks ! I only had the referrence. Good article. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2006 Report Share Posted March 23, 2006 Yes, the intesines also, sorry. But it is not what causes overall organ failure. It is linked to diarreha however. BTW, here is the link to the journal article you cites: http://content.nejm.org/cgi/content/full/353/13/1374 --- sterten@... wrote: > > In einer eMail vom 24.03.2006 00:41:53 > Westeuropäische Normalzeit schreibt > darkdaysarecoming@...: > > H5N1 does not infect or live anywhere but in the > pulminary system. > > J.H.Beigel et.al. NEnglJMed,353,1374(Sep29,2005) > showed H5N1 in human intestine > __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 23, 2006 Report Share Posted March 23, 2006 It seems to me that the involvement of organ systems beyond the respiratory have more to do with the body's overall immune response which is so overwhelming as to cause, in some cases, multiple organ failure. I have seen similar things happen with other infectious diseases when I was in clinical practice. The body will fight infection very strongly but sometimes the body can go just so far even when appropriate medical interventions are in place.Dark Man <darkdaysarecoming@...> wrote: Yes, the intesines also, sorry. But it is not whatcauses overall organ failure. It is linked to diarrehahowever.BTW, here is the link to the journal article youcites:http://content.nejm.org/cgi/content/full/353/13/1374--- sterten@... wrote:> > In einer eMail vom 24.03.2006 00:41:53> Westeuropäische Normalzeit schreibt > darkdaysarecoming@...:> > H5N1 does not infect or live anywhere but in the> pulminary system. > > J.H.Beigel et.al. NEnglJMed,353,1374(Sep29,2005)> showed H5N1 in human intestine> __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 25, 2006 Report Share Posted March 25, 2006 I also vaguely remember an interview with Webster, where he said, H5N1 were going up the central nervous system in the spine up into the head. In 1918 most people still died of pneumonia, I think. Yes, cytokine storm was a problem but only in some % of people (from Berry's book, AFAIR) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 25, 2006 Report Share Posted March 25, 2006 It is now thought that the deaths in the 1918/19 pandemic were largely caused by the victims' immune response over-reacting to a virus which which " embedded itself " in regions of the lungs which ordinary Winter flu doesn't get to. Descriptions of the dying include " the face turning purple, and coughing and retching " as the lungs filled with the victims'own blood: ergo, they drowned in their own blood. It explains why ordinarily healthy, young, fit people contracted this disease more readily; their immune system was more active, prompting death. > > > > > In einer eMail vom 24.03.2006 00:41:53 > > Westeuropäische Normalzeit schreibt > > darkdaysarecoming@...: > > > > H5N1 does not infect or live anywhere but in the > > pulminary system. > > > > J.H.Beigel et.al. NEnglJMed,353,1374(Sep29,2005) > > showed H5N1 in human intestine > > > > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 27, 2006 Report Share Posted March 27, 2006 (Re: " largely caused by the victims' immune response over-reacting " ) Hi, I've been lurking here for a while, just soaking up all the info. However, this topic did get my attention and I really would like to know more about it. Does this mean that people with Autoimmune disorders, (Diabetes, Celiac Disease, Lupus, Rheumatoid Arthritis, etc) would be more susceptible to this? Has there been any studies to indicated that most of the victims had an autoimmune disease? Just curious? ~Sky > > > It is now thought that the deaths in the 1918/19 pandemic were > largely caused by the victims' immune response over-reacting to a > virus which which " embedded itself " in regions of the lungs which > ordinary Winter flu doesn't get to. > > Descriptions of the dying include " the face turning purple, and > coughing and retching " as the lungs filled with the victims'own > blood: ergo, they drowned in their own blood. It explains why > ordinarily healthy, young, fit people contracted this disease more > readily; their immune system was more active, prompting death. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 27, 2006 Report Share Posted March 27, 2006 People with autoimmune diesases would only be more susceptible to dying, not more susceptible to getting Avian Flu. --- Beth <skylark7k@...> wrote: > (Re: " largely caused by the victims' immune response > over-reacting " ) > > Hi, I've been lurking here for a while, just soaking > up all the info. > However, this topic did get my attention and I > really would like to > know more about it. Does this mean that people with > Autoimmune > disorders, (Diabetes, Celiac Disease, Lupus, > Rheumatoid Arthritis, > etc) would be more susceptible to this? Has there > been any studies to > indicated that most of the victims had an autoimmune > disease? Just > curious? > > ~Sky > > > > > > > > It is now thought that the deaths in the 1918/19 > pandemic were > > largely caused by the victims' immune response > over-reacting to a > > virus which which " embedded itself " in regions of > the lungs which > > ordinary Winter flu doesn't get to. > > > > Descriptions of the dying include " the face > turning purple, and > > coughing and retching " as the lungs filled with > the victims'own > > blood: ergo, they drowned in their own blood. It > explains why > > ordinarily healthy, young, fit people contracted > this disease more > > readily; their immune system was more active, > prompting death. > > > > > > > > > __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 I'm taking the bull by the horns at this point. I am very unsatisfied at the ability of my docs to fix the pain I have left and/or to medicate it properly....without the use of a spine stim...at least not yet! The worst of my pain comes from my right L5 facet joint. Not at all uncommon considering I am fused from L4 to S1...it's made worse still by the fact that at 21 years of age, my third surgery was my first fusion. This pioneering young doctor from big name Boston Hospital...tells me all about this new technique he's using. I'll be the youngest patient ever. He says I'll have less pain after surgery and my recovery will be much faster. It's called Lumbar Fusion with Facet Fixation...normal fixation for the fusion process is done by placing heavy duty screws into the stronger bone of the vertebrae's pedicles. This new procedure involves much less hardware. The less sturdy screws are drilled through the less sturdy and highly innervated facet joint, immediately ceasing motion thereby creating stability. So the process was intended. Long story short, a few years later I was in agonizing pain all day long. Went to see Boston doc who gave me MRI...I never saw it or report. He just immediately offered surgery and I could literally have it tomorrow if I wanted. Hmmm....should have seemed weird to me. Didn't want surgery AGAIN...DUH! So he suggested facet injection. I went to my own pain clinic at my Big Boston Hospital where I worked. What they saw upon xray made them catch their breath. First they had never seen facet fixation so the screw placement was new to them. Worse than that, the screw traversing my right facet joint was badly broken and wearing into my facet joint. The left facet screw was also broken, but still in place. Add to that the condition of what was supposed to be my fusion...It was all crumbled and fractured bone!!! At this point I'd been walking around like this for three years. Amazing that I could stand the pain. They looked at me and said...your only way out of this is surgery dear. Oh God NOOOOO! Three surgeries later, I am so much better and can function quite well. I do have pain every day but I'm not given adequate medication so I suffer. The direct source of 90% of my pain is that right facet joint that had the broken screw. It's been killing me for years. Nobody seems to understand whats going on...so I'm doing a little research on my own to see what it is and if there's anything to help. I will post here some links to interesting info, wether it be specifically for facets or not. Hope some of you find it useful! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 http://www.chiropractic-books.com/Immobilisation-Arthritis.html Anyone here been told of Immobilization Arthritis???? ________________________________ From: B <tpowell1977@...> spinal problems Sent: Thu, September 2, 2010 5:02:24 AM Subject: New Information I'm taking the bull by the horns at this point. I am very unsatisfied at the ability of my docs to fix the pain I have left and/or to medicate it properly....without the use of a spine stim...at least not yet! The worst of my pain comes from my right L5 facet joint. Not at all uncommon considering I am fused from L4 to S1...it's made worse still by the fact that at 21 years of age, my third surgery was my first fusion. This pioneering young doctor from big name Boston Hospital...tells me all about this new technique he's using. I'll be the youngest patient ever. He says I'll have less pain after surgery and my recovery will be much faster. It's called Lumbar Fusion with Facet Fixation...normal fixation for the fusion process is done by placing heavy duty screws into the stronger bone of the vertebrae's pedicles. This new procedure involves much less hardware. The less sturdy screws are drilled through the less sturdy and highly innervated facet joint, immediately ceasing motion thereby creating stability. So the process was intended. Long story short, a few years later I was in agonizing pain all day long. Went to see Boston doc who gave me MRI...I never saw it or report. He just immediately offered surgery and I could literally have it tomorrow if I wanted. Hmmm....should have seemed weird to me. Didn't want surgery AGAIN...DUH! So he suggested facet injection. I went to my own pain clinic at my Big Boston Hospital where I worked. What they saw upon xray made them catch their breath. First they had never seen facet fixation so the screw placement was new to them. Worse than that, the screw traversing my right facet joint was badly broken and wearing into my facet joint. The left facet screw was also broken, but still in place. Add to that the condition of what was supposed to be my fusion...It was all crumbled and fractured bone!!! At this point I'd been walking around like this for three years. Amazing that I could stand the pain. They looked at me and said...your only way out of this is surgery dear. Oh God NOOOOO! Three surgeries later, I am so much better and can function quite well. I do have pain every day but I'm not given adequate medication so I suffer. The direct source of 90% of my pain is that right facet joint that had the broken screw. It's been killing me for years. Nobody seems to understand whats going on...so I'm doing a little research on my own to see what it is and if there's anything to help. I will post here some links to interesting info, wether it be specifically for facets or not. Hope some of you find it useful! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 , That is a horrible story and I'm so sorry you had to go through it! I made a similar mistake of going with someone who was trying something new with C1-2 fusions and screws, he had just published in a leading journal and assured me he could do something much better with his use of screws than what had been done that had resulted in a failed fusion. I went with it and, like you, ended up with broken screws and it necessitated another redo of the fusion. My first question now will be how many of these have you done? and How many were successful? I will be very interested in your research. Best, Kate From: Babbitt Sent: Thursday, September 02, 2010 5:04 AM spinal problems Subject: Re: New Information http://www.chiropractic-books.com/Immobilisation-Arthritis.html Anyone here been told of Immobilization Arthritis???? ________________________________ From: B <tpowell1977@...> spinal problems Sent: Thu, September 2, 2010 5:02:24 AM Subject: New Information I'm taking the bull by the horns at this point. I am very unsatisfied at the ability of my docs to fix the pain I have left and/or to medicate it properly....without the use of a spine stim...at least not yet! The worst of my pain comes from my right L5 facet joint. Not at all uncommon considering I am fused from L4 to S1...it's made worse still by the fact that at 21 years of age, my third surgery was my first fusion. This pioneering young doctor from big name Boston Hospital...tells me all about this new technique he's using. I'll be the youngest patient ever. He says I'll have less pain after surgery and my recovery will be much faster. It's called Lumbar Fusion with Facet Fixation...normal fixation for the fusion process is done by placing heavy duty screws into the stronger bone of the vertebrae's pedicles. This new procedure involves much less hardware. The less sturdy screws are drilled through the less sturdy and highly innervated facet joint, immediately ceasing motion thereby creating stability. So the process was intended. Long story short, a few years later I was in agonizing pain all day long. Went to see Boston doc who gave me MRI...I never saw it or report. He just immediately offered surgery and I could literally have it tomorrow if I wanted. Hmmm....should have seemed weird to me. Didn't want surgery AGAIN...DUH! So he suggested facet injection. I went to my own pain clinic at my Big Boston Hospital where I worked. What they saw upon xray made them catch their breath. First they had never seen facet fixation so the screw placement was new to them. Worse than that, the screw traversing my right facet joint was badly broken and wearing into my facet joint. The left facet screw was also broken, but still in place. Add to that the condition of what was supposed to be my fusion...It was all crumbled and fractured bone!!! At this point I'd been walking around like this for three years. Amazing that I could stand the pain. They looked at me and said...your only way out of this is surgery dear. Oh God NOOOOO! Three surgeries later, I am so much better and can function quite well. I do have pain every day but I'm not given adequate medication so I suffer. The direct source of 90% of my pain is that right facet joint that had the broken screw. It's been killing me for years. Nobody seems to understand whats going on...so I'm doing a little research on my own to see what it is and if there's anything to help. I will post here some links to interesting info, wether it be specifically for facets or not. Hope some of you find it useful! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 2, 2010 Report Share Posted September 2, 2010 WOW you have had a lot to deal with haven't you? I too had a broken screw in my lumbar fusion they couldn't get it out so it's still there. It doesn't bother me it's stuck in the bone so it's not interfeering with anything and as long as it doesn't hurt me it can stay there. I had no idea our bones were that strong. I have seen the drills and the screwdrivers they use and they are pretty intimaditing. I now have severe osteoporosis so I bet it would come out now but there is no reason to mess with it. The biggest problem I have ahd this year with my lower body has been my hips and legs. I just can't walk very far or very fast. The pain is just awful. I see a vascular doctor next week maybe he can shed some light on the subject. I had 4 stents put in my heart in March so it stands to reason if my arteries in my heart were blocked the ones in my legs very well could be also. It would explain the pain and my inability to walk very much. I like this group I seem to fit right in. Janice New Information I'm taking the bull by the horns at this point. I am very unsatisfied at the ability of my docs to fix the pain I have left and/or to medicate it properly....without the use of a spine stim...at least not yet! The worst of my pain comes from my right L5 facet joint. Not at all uncommon considering I am fused from L4 to S1...it's made worse still by the fact that at 21 years of age, my third surgery was my first fusion. This pioneering young doctor from big name Boston Hospital...tells me all about this new technique he's using. I'll be the youngest patient ever. He says I'll have less pain after surgery and my recovery will be much faster. It's called Lumbar Fusion with Facet Fixation...normal fixation for the fusion process is done by placing heavy duty screws into the stronger bone of the vertebrae's pedicles. This new procedure involves much less hardware. The less sturdy screws are drilled through the less sturdy and highly innervated facet joint, immediately ceasing motion thereby creating stability. So the process was intended. Long story short, a few years later I was in agonizing pain all day long. Went to see Boston doc who gave me MRI...I never saw it or report. He just immediately offered surgery and I could literally have it tomorrow if I wanted. Hmmm....should have seemed weird to me. Didn't want surgery AGAIN...DUH! So he suggested facet injection. I went to my own pain clinic at my Big Boston Hospital where I worked. What they saw upon xray made them catch their breath. First they had never seen facet fixation so the screw placement was new to them. Worse than that, the screw traversing my right facet joint was badly broken and wearing into my facet joint. The left facet screw was also broken, but still in place. Add to that the condition of what was supposed to be my fusion...It was all crumbled and fractured bone!!! At this point I'd been walking around like this for three years. Amazing that I could stand the pain. They looked at me and said...your only way out of this is surgery dear. Oh God NOOOOO! Three surgeries later, I am so much better and can function quite well. I do have pain every day but I'm not given adequate medication so I suffer. The direct source of 90% of my pain is that right facet joint that had the broken screw. It's been killing me for years. Nobody seems to understand whats going on...so I'm doing a little research on my own to see what it is and if there's anything to help. I will post here some links to interesting info, wether it be specifically for facets or not. Hope some of you find it useful! ------------------------------------------------------------------------------ No virus found in this incoming message. Checked by AVG - www.avg.com Version: 9.0.851 / Virus Database: 271.1.1/3106 - Release Date: 08/31/10 23:34:00 Quote Link to comment Share on other sites More sharing options...
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