RE: question about injections (pat??)

February 3, 2006

,

I do 375 myself also, but was shown how to do it as two equal injections. I

don't get a bump.

I receive three bottles of (dry) Xolair and two small bottles of sterile

water for each injection. I inject 1.4 ml of water into each of the three

bottles

of Xolair. Then I roll the bottles around until it's all dissolved. Then i

withdraw a total of 1.5 ml of liquid from the three bottles of Xolair into

each of two syrninges, so I end up with two 1.5 ml syringes.

I learned from the nurse in my doctor's office (the only one who gave a good

injection) that the least painful place to inject it was the very top of my

outer thigh (a couple of inches below underwear line).

I'm wondering if doing two equal injections would help you.

Best,

Meryl

hi all. i hope this finds everyone well.

i've just got a question. i'm on xolair 375 mg every 2 weeks. i've been

injecting myself since my 3rd or 4th dose TWO years ago! this past year i've

been doing it unsupervised (YEAH -- no " babysitters " to watch me in the drs

office!!).

when the xolair rep originally came to show us what to do, he set up my

injections as (2) 1.2 mL injections and (1) .6 mL injection. we roate injection

sites - both thighs, stomach and left arm.

when i inject the 1.2 mL of xolair into my arm, i get a bubble/bump,

probably the size of a quarter. its almost like my arm cannot absorb the xolair

as

fast as i'm pushing it in (and trust me, its not fast -- its like jello going

in - LOL). the bubble goes away after 4-6 hours, i guess as my arm absorbs the

xolair. i don't get a bubble with the .6 mL injection into my arm. the other

injection sites go into fattier tissue, so i'm guessing that's why i don't

get a bubble there.

i talked to one of the nurses at school (i work in a school for medically

fragile kids, so the nurses are really good there) about it. she looked it up,

said it was " normal " and told me to try to inject more towards the underside

of my arm where there's a little more fat. since i'm not gumby, its easier said

than done.

does anyone else get this? i don't want to mention it to the dr/nurse if i

can avoid it because i don't want my self injecting priviledges taken away. i

looked at the administration directions on the xolair site (

http://www.xolair.com/hcp/preparation_administration.jsp#preparing_the_reconstit\

uted_dose_for_i

njection )

and it mentions a " mass " as an injection site reaction, but i'm not sure if

they're talking about a mass due to the solution not being absorbed

immediately or some people just develop a bump (similar to swelling).

any ideas?

thanks

heather

" There is a time in every man's education when he arrives at the conviction

that envy is ignorance; that imitation is suicide; that he must take himself

for better, for worse, as his portion; that though the wide universe is full of

good, no kernel of nourishing corn can come to him but through his toil

bestowed on that plot of ground which is given to him to till. "

-- Ralph Waldo Emerson

---------------------------------

- Helps protect you from nasty viruses.

February 3, 2006

I self inject the same as you, only at home. I never use my left arm

because of the gumby syndrome! I use thighs and stomach. My rotating

sites consists of " high and low " locations on the thighs and stomach.

When the nurse was injecting into my shoulders I never noticed a

lump, but to be honest I never looked and the nurse never said

anything except get the hell out of here, I think I recognized her

from One Flew Over the Cuckoo's Nest, actually she was a very nice

person and didn't mind me being in the fetal position in the corner,

crying and snotting, and that was before the shot!

Thanks for the link to the Xolair site.

Ron

On Feb 3, 2006, at 3:48 AM, heather wrote:

> hi all. i hope this finds everyone well.

>

> i've just got a question. i'm on xolair 375 mg every 2 weeks.

> i've been injecting myself since my 3rd or 4th dose TWO years ago!

> this past year i've been doing it unsupervised (YEAH -- no

> " babysitters " to watch me in the drs office!!).

>

> when the xolair rep originally came to show us what to do, he set

> up my injections as (2) 1.2 mL injections and (1) .6 mL injection.

> we roate injection sites - both thighs, stomach and left arm.

>

> when i inject the 1.2 mL of xolair into my arm, i get a bubble/

> bump, probably the size of a quarter. its almost like my arm cannot

> absorb the xolair as fast as i'm pushing it in (and trust me, its

> not fast -- its like jello going in - LOL). the bubble goes away

> after 4-6 hours, i guess as my arm absorbs the xolair. i don't get

> a bubble with the .6 mL injection into my arm. the other injection

> sites go into fattier tissue, so i'm guessing that's why i don't

> get a bubble there.

>

> i talked to one of the nurses at school (i work in a school for

> medically fragile kids, so the nurses are really good there) about

> it. she looked it up, said it was " normal " and told me to try to

> inject more towards the underside of my arm where there's a little

> more fat. since i'm not gumby, its easier said than done.

>

> does anyone else get this? i don't want to mention it to the dr/

> nurse if i can avoid it because i don't want my self injecting

> priviledges taken away. i looked at the administration directions

> on the xolair site ( http://www.xolair.com/hcp/

> preparation_administration.jsp#preparing_the_reconstituted_dose_for_in

> jection )

> and it mentions a " mass " as an injection site reaction, but i'm

> not sure if they're talking about a mass due to the solution not

> being absorbed immediately or some people just develop a bump

> (similar to swelling).

>

> any ideas?

>

> thanks

>

> heather

>

> " There is a time in every man's education when he arrives at the

> conviction that envy is ignorance; that imitation is suicide; that

> he must take himself for better, for worse, as his portion; that

> though the wide universe is full of good, no kernel of nourishing

> corn can come to him but through his toil bestowed on that plot of

> ground which is given to him to till. "

> -- Ralph Waldo Emerson

>

> ---------------------------------

> - Helps protect you from nasty viruses.

>

February 3, 2006

I noticed this when the nurse at the office gave me the injections.

When I asked her about this she said that XOLAIR is a very thick

medication and as such it takes a little time for the medication to get

absorbed into the body. She also indicated as you found out the

fattier the area the less of a lump that is seen and the faster it gets

absorbed. According to her this was nothing to be concerned about.

________________________________

From: [mailto: ]

On Behalf Of heather

Sent: Friday, February 03, 2006 3:49 AM

Subject: [ ] question about injections (pat??)

hi all. i hope this finds everyone well.

i've just got a question. i'm on xolair 375 mg every 2 weeks. i've

been injecting myself since my 3rd or 4th dose TWO years ago! this past

year i've been doing it unsupervised (YEAH -- no " babysitters " to watch

me in the drs office!!).

when the xolair rep originally came to show us what to do, he set up

my injections as (2) 1.2 mL injections and (1) .6 mL injection. we

roate injection sites - both thighs, stomach and left arm.

when i inject the 1.2 mL of xolair into my arm, i get a bubble/bump,

probably the size of a quarter. its almost like my arm cannot absorb the

xolair as fast as i'm pushing it in (and trust me, its not fast -- its

like jello going in - LOL). the bubble goes away after 4-6 hours, i

guess as my arm absorbs the xolair. i don't get a bubble with the .6 mL

injection into my arm. the other injection sites go into fattier

tissue, so i'm guessing that's why i don't get a bubble there.

i talked to one of the nurses at school (i work in a school for

medically fragile kids, so the nurses are really good there) about it.

she looked it up, said it was " normal " and told me to try to inject more

towards the underside of my arm where there's a little more fat. since

i'm not gumby, its easier said than done.

does anyone else get this? i don't want to mention it to the dr/nurse

if i can avoid it because i don't want my self injecting priviledges

taken away. i looked at the administration directions on the xolair site

(

http://www.xolair.com/hcp/preparation_administration.jsp#preparing_the_r

econstituted_dose_for_injection )

and it mentions a " mass " as an injection site reaction, but i'm not

sure if they're talking about a mass due to the solution not being

absorbed immediately or some people just develop a bump (similar to

swelling).

any ideas?

thanks

heather

" There is a time in every man's education when he arrives at the

conviction that envy is ignorance; that imitation is suicide; that he

must take himself for better, for worse, as his portion; that though the

wide universe is full of good, no kernel of nourishing corn can come to

him but through his toil bestowed on that plot of ground which is given

to him to till. "

-- Ralph Waldo Emerson

---------------------------------

- Helps protect you from nasty viruses.

February 3, 2006

subcutaneous injections shouldn't have more than 1cc. Yes it makes sense to do

2 shots instead of 3 if you have no problems. so the 1.5 cc you are using if

you have no troubles is ok for you. I'd rather you do it in 3 shots though.

Also, the angle of the injection is very important. It should be at a 90 degree

angle toward the center of the belly, thigh or arm depending on injection

site.For example, if using upper outer thigh and sitting in chair, syringe

should be parallel to floor and perpendicular to thigh.

hope that helped.

Pat

---------------------------------

Relax. virus scanning helps detect nasty viruses!

February 3, 2006

I agree with Pat; what I read from the manufacturer and what I was

instructed to do when I was taking 375mg every two weeks was to give

myself 3 shots.

February 3, 2006

The volume that your subcue space can handle is pretty

small. Can they mix the entire dose equally into 3

syringes so each will have less than 1.2?

Just an idea!

ps Or don't inject in your arm. I do it in my stomach

flab since I shake too hard to hold the needle in my

arm.

__________________________________________________________

Find your next car at http://autos..ca

February 4, 2006

You are right Steve, there really is nothing to worry about when you have a lump

at the injection site. I is unsightly and may itch and get hot. The medication

is akin in thickness to honey. If the injection angle is less than 90 degrees

there is way more chance to have the bump. Xolair can be given upper outer arm.

For thin peopple, they may want to ask about upper outer thighs, buttocks or

even abdomen. Thin probably isn't too much of a problem since most of us were

or are on steroids!

Pat

---------------------------------

- Helps protect you from nasty viruses.

February 5, 2006

hi pat,

thanks for clearing up the bumpy mystery for me!!! i guess i should be glad

that my arms are getting the bump, since that means i've shed some of the pred

weight!!!!!!!

=o)

thanks again for all your advice

heather

MommaA <mommaa@...> wrote:

You are right Steve, there really is nothing to worry about when you have a

lump at the injection site. I is unsightly and may itch and get hot. The

medication is akin in thickness to honey. If the injection angle is less than

90 degrees there is way more chance to have the bump. Xolair can be given upper

outer arm. For thin peopple, they may want to ask about upper outer thighs,

buttocks or even abdomen. Thin probably isn't too much of a problem since most

of us were or are on steroids!

Pat

---------------------------------

- Helps protect you from nasty viruses.

February 5, 2006

ron, your sense of humor always makes me laugh!!!!

~heather

Carpenter <cowtrail@...> wrote: