Guest guest Posted March 28, 2000 Report Share Posted March 28, 2000 Claudine, How are you? and have you done anything yet regarding new treatment or waiting? It was an interesting article but thought I had read that 1b was the most prevalent somewhere at 70% of course, think that was the world. I'll have to see if I can find that article. weird lots of people here have 1b then mostly found on Europe. ell wantee to seee how you were and ty for the article. I have almost completed week 4, not doing too bad over all but did feel like quitting last week so still have rough days, I just hope it clears, can't imagine going through all this and then it not helping but then you've been there and you have to take the chance. Thasts the main reason why people try to see if they will be one of the few that it helps. wishh the research would move along a little faster but then its hard when you have a disease that affects you personally . Much more empathetic towards all diseases now, well take care and will talk to you later Suzy From: " Claudine Crews " <claudinecrews@...> Reply-Hepatitis Conelist Hepatitis Conelist Subject: Genotypes Explained Date: Tue, 28 Mar 2000 12:54:11 CST This has to be the best article I've seen that explains genotypes. You can actually understand! Genotypes Explained It is much easier to talk of the hepatitis C virus as if it is a single organism but in fact it is a range of viruses, similar enough to be called hepatitis C virus, yet different enough to be classified into subgroups. Viruses are microscopic and no person could ever see them with the naked eye. Indeed, HCV is so small that there’s been no confirmed actual sighting of it using any type of microscope yet developed (see Ed 17, p1). Consequently, a better way to understand the terms HCV ‘genotypes’ and ‘subtypes’ is to compare them to things that we can more readily relate to. Genotypes The group of birds we call ‘raptors’ (birds of prey) have evolved into different main types. Imagining raptors as being hepatitis C viruses, you could take one major raptor type, such as eagles, and imagine these as being one of HCV’s main types (genotypes). Subtypes But eagles as a group are made up of different sub types such as the American Bald Eagle and Australia’s Wedge Tailed Eagle and Sea Eagle. You could imagine each of these as being one of the HCV subtypes that make up an HCV genotype. Quasispecies Within each of above particular types of eagles, there are further differences. All Wedge Tailed Eagles, for example, differ from each other in regard to wing span, weight, colour, beak size, etc. Similarly, within a hepatitis C sub-type, individual viruses differ from each other ever so slightly. Such viral differences are not significant enough to form another sub-type but instead form what’s known as quasi-species. It is believed that within an HCV sub-type, several million quasispecies may exist. Scientists predict that people who have hepatitis C, have billions of actual viruses circulating within their body. Although there may be one or two predominant sub-types, the infection as a whole is not a single entity and is composed of many different quasispecies. Classifications Biologists are generally not known for creativity when it comes to naming things - hence hepatitis C virus. The most commonly used classification of hepatitis C virus has HCV divided into the following genotypes (main types): 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11. As we’ve highlighted, HCV genotypes can be broken down into sub-types, some of which include: 1a, 1b, 1c 2a, 2b, 2c 3a, 3b 4a, 4b, 4c, 4d, 4e 5a 6a 7a, 7b 8a, 8b 9a 10a 11a Genotype patterns It is believed that the hepatitis C virus has evolved over a period of several thousand years (see Ed 20, p7). This would explain the current general global patterns of genotypes and subtypes: 1a - mostly found in Nth & Sth America; also common in Australia 1b - mostly found in Europe and Asia. 2a - is the most common genotype 2 in Japan and China. 2b - is the most common genotype 2 in the US and Nthn Europe. 2c - the most common genotype 2 in Wstn and Sthn Europe. 3a - highly prevalent here in Australia (40% of cases) and Sth Asia. 4a - highly prevalent in Egypt 4c - highly prevalent in Central Africa 5a - highly prevalent only in Sth Africa 6a - restricted to Hong Kong, Macau and Vietnam 7a and 7b - common in Thailand 8a, 8b & 9a - prevalent in Vietnam 10a & 11a - found in Indonesia It’s believed that of the estimated 160,000 Australians with HCV, approx. 35% have subtype ‘1a’, 15% have ‘1b’, 7% have ‘2’, 35% have ‘3’ (mostly being 3a). The remaining people would have other genotypes. Genotype and treatment Current scientific belief is that factors such as duration of a person’s HCV infection, their HCV viral load, age, grade of liver inflammation or stage of fibrosis may play an important role in determining response to interferon treatment. Recent studies have suggested that a person’s HCV subtype (or subtypes) may influence their possible response to interferon, or interferon-ribavirin combination treatment. World-wide trials are being conducted which will soon shed more light on this belief. We’ll publish any reports as they come to hand. Info taken from Genotypes and Genetic Variation of Hepatitis C Virus by G. Maerterns & L. Stuyver, reviewed by Dr Greg Dore of the National Centre in HIV Epidemiology & Clinical Research. From The Hep C Review; Ed 23, December 1998; Harvey ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 28, 2000 Report Share Posted March 28, 2000 Claudine, How are you? and have you done anything yet regarding new treatment or waiting? It was an interesting article but thought I had read that 1b was the most prevalent somewhere at 70% of course, think that was the world. I'll have to see if I can find that article. weird lots of people here have 1b then mostly found on Europe. ell wantee to seee how you were and ty for the article. I have almost completed week 4, not doing too bad over all but did feel like quitting last week so still have rough days, I just hope it clears, can't imagine going through all this and then it not helping but then you've been there and you have to take the chance. Thasts the main reason why people try to see if they will be one of the few that it helps. wishh the research would move along a little faster but then its hard when you have a disease that affects you personally . Much more empathetic towards all diseases now, well take care and will talk to you later Suzy From: " Claudine Crews " <claudinecrews@...> Reply-Hepatitis Conelist Hepatitis Conelist Subject: Genotypes Explained Date: Tue, 28 Mar 2000 12:54:11 CST This has to be the best article I've seen that explains genotypes. You can actually understand! Genotypes Explained It is much easier to talk of the hepatitis C virus as if it is a single organism but in fact it is a range of viruses, similar enough to be called hepatitis C virus, yet different enough to be classified into subgroups. Viruses are microscopic and no person could ever see them with the naked eye. Indeed, HCV is so small that there’s been no confirmed actual sighting of it using any type of microscope yet developed (see Ed 17, p1). Consequently, a better way to understand the terms HCV ‘genotypes’ and ‘subtypes’ is to compare them to things that we can more readily relate to. Genotypes The group of birds we call ‘raptors’ (birds of prey) have evolved into different main types. Imagining raptors as being hepatitis C viruses, you could take one major raptor type, such as eagles, and imagine these as being one of HCV’s main types (genotypes). Subtypes But eagles as a group are made up of different sub types such as the American Bald Eagle and Australia’s Wedge Tailed Eagle and Sea Eagle. You could imagine each of these as being one of the HCV subtypes that make up an HCV genotype. Quasispecies Within each of above particular types of eagles, there are further differences. All Wedge Tailed Eagles, for example, differ from each other in regard to wing span, weight, colour, beak size, etc. Similarly, within a hepatitis C sub-type, individual viruses differ from each other ever so slightly. Such viral differences are not significant enough to form another sub-type but instead form what’s known as quasi-species. It is believed that within an HCV sub-type, several million quasispecies may exist. Scientists predict that people who have hepatitis C, have billions of actual viruses circulating within their body. Although there may be one or two predominant sub-types, the infection as a whole is not a single entity and is composed of many different quasispecies. Classifications Biologists are generally not known for creativity when it comes to naming things - hence hepatitis C virus. The most commonly used classification of hepatitis C virus has HCV divided into the following genotypes (main types): 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11. As we’ve highlighted, HCV genotypes can be broken down into sub-types, some of which include: 1a, 1b, 1c 2a, 2b, 2c 3a, 3b 4a, 4b, 4c, 4d, 4e 5a 6a 7a, 7b 8a, 8b 9a 10a 11a Genotype patterns It is believed that the hepatitis C virus has evolved over a period of several thousand years (see Ed 20, p7). This would explain the current general global patterns of genotypes and subtypes: 1a - mostly found in Nth & Sth America; also common in Australia 1b - mostly found in Europe and Asia. 2a - is the most common genotype 2 in Japan and China. 2b - is the most common genotype 2 in the US and Nthn Europe. 2c - the most common genotype 2 in Wstn and Sthn Europe. 3a - highly prevalent here in Australia (40% of cases) and Sth Asia. 4a - highly prevalent in Egypt 4c - highly prevalent in Central Africa 5a - highly prevalent only in Sth Africa 6a - restricted to Hong Kong, Macau and Vietnam 7a and 7b - common in Thailand 8a, 8b & 9a - prevalent in Vietnam 10a & 11a - found in Indonesia It’s believed that of the estimated 160,000 Australians with HCV, approx. 35% have subtype ‘1a’, 15% have ‘1b’, 7% have ‘2’, 35% have ‘3’ (mostly being 3a). The remaining people would have other genotypes. Genotype and treatment Current scientific belief is that factors such as duration of a person’s HCV infection, their HCV viral load, age, grade of liver inflammation or stage of fibrosis may play an important role in determining response to interferon treatment. Recent studies have suggested that a person’s HCV subtype (or subtypes) may influence their possible response to interferon, or interferon-ribavirin combination treatment. World-wide trials are being conducted which will soon shed more light on this belief. We’ll publish any reports as they come to hand. Info taken from Genotypes and Genetic Variation of Hepatitis C Virus by G. Maerterns & L. Stuyver, reviewed by Dr Greg Dore of the National Centre in HIV Epidemiology & Clinical Research. From The Hep C Review; Ed 23, December 1998; Harvey ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 28, 2000 Report Share Posted March 28, 2000 Claudine, How are you? and have you done anything yet regarding new treatment or waiting? It was an interesting article but thought I had read that 1b was the most prevalent somewhere at 70% of course, think that was the world. I'll have to see if I can find that article. weird lots of people here have 1b then mostly found on Europe. ell wantee to seee how you were and ty for the article. I have almost completed week 4, not doing too bad over all but did feel like quitting last week so still have rough days, I just hope it clears, can't imagine going through all this and then it not helping but then you've been there and you have to take the chance. Thasts the main reason why people try to see if they will be one of the few that it helps. wishh the research would move along a little faster but then its hard when you have a disease that affects you personally . Much more empathetic towards all diseases now, well take care and will talk to you later Suzy From: " Claudine Crews " <claudinecrews@...> Reply-Hepatitis Conelist Hepatitis Conelist Subject: Genotypes Explained Date: Tue, 28 Mar 2000 12:54:11 CST This has to be the best article I've seen that explains genotypes. You can actually understand! Genotypes Explained It is much easier to talk of the hepatitis C virus as if it is a single organism but in fact it is a range of viruses, similar enough to be called hepatitis C virus, yet different enough to be classified into subgroups. Viruses are microscopic and no person could ever see them with the naked eye. Indeed, HCV is so small that there’s been no confirmed actual sighting of it using any type of microscope yet developed (see Ed 17, p1). Consequently, a better way to understand the terms HCV ‘genotypes’ and ‘subtypes’ is to compare them to things that we can more readily relate to. Genotypes The group of birds we call ‘raptors’ (birds of prey) have evolved into different main types. Imagining raptors as being hepatitis C viruses, you could take one major raptor type, such as eagles, and imagine these as being one of HCV’s main types (genotypes). Subtypes But eagles as a group are made up of different sub types such as the American Bald Eagle and Australia’s Wedge Tailed Eagle and Sea Eagle. You could imagine each of these as being one of the HCV subtypes that make up an HCV genotype. Quasispecies Within each of above particular types of eagles, there are further differences. All Wedge Tailed Eagles, for example, differ from each other in regard to wing span, weight, colour, beak size, etc. Similarly, within a hepatitis C sub-type, individual viruses differ from each other ever so slightly. Such viral differences are not significant enough to form another sub-type but instead form what’s known as quasi-species. It is believed that within an HCV sub-type, several million quasispecies may exist. Scientists predict that people who have hepatitis C, have billions of actual viruses circulating within their body. Although there may be one or two predominant sub-types, the infection as a whole is not a single entity and is composed of many different quasispecies. Classifications Biologists are generally not known for creativity when it comes to naming things - hence hepatitis C virus. The most commonly used classification of hepatitis C virus has HCV divided into the following genotypes (main types): 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11. As we’ve highlighted, HCV genotypes can be broken down into sub-types, some of which include: 1a, 1b, 1c 2a, 2b, 2c 3a, 3b 4a, 4b, 4c, 4d, 4e 5a 6a 7a, 7b 8a, 8b 9a 10a 11a Genotype patterns It is believed that the hepatitis C virus has evolved over a period of several thousand years (see Ed 20, p7). This would explain the current general global patterns of genotypes and subtypes: 1a - mostly found in Nth & Sth America; also common in Australia 1b - mostly found in Europe and Asia. 2a - is the most common genotype 2 in Japan and China. 2b - is the most common genotype 2 in the US and Nthn Europe. 2c - the most common genotype 2 in Wstn and Sthn Europe. 3a - highly prevalent here in Australia (40% of cases) and Sth Asia. 4a - highly prevalent in Egypt 4c - highly prevalent in Central Africa 5a - highly prevalent only in Sth Africa 6a - restricted to Hong Kong, Macau and Vietnam 7a and 7b - common in Thailand 8a, 8b & 9a - prevalent in Vietnam 10a & 11a - found in Indonesia It’s believed that of the estimated 160,000 Australians with HCV, approx. 35% have subtype ‘1a’, 15% have ‘1b’, 7% have ‘2’, 35% have ‘3’ (mostly being 3a). The remaining people would have other genotypes. Genotype and treatment Current scientific belief is that factors such as duration of a person’s HCV infection, their HCV viral load, age, grade of liver inflammation or stage of fibrosis may play an important role in determining response to interferon treatment. Recent studies have suggested that a person’s HCV subtype (or subtypes) may influence their possible response to interferon, or interferon-ribavirin combination treatment. World-wide trials are being conducted which will soon shed more light on this belief. We’ll publish any reports as they come to hand. Info taken from Genotypes and Genetic Variation of Hepatitis C Virus by G. Maerterns & L. Stuyver, reviewed by Dr Greg Dore of the National Centre in HIV Epidemiology & Clinical Research. From The Hep C Review; Ed 23, December 1998; Harvey ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 28, 2000 Report Share Posted March 28, 2000 Claudine, How are you? and have you done anything yet regarding new treatment or waiting? It was an interesting article but thought I had read that 1b was the most prevalent somewhere at 70% of course, think that was the world. I'll have to see if I can find that article. weird lots of people here have 1b then mostly found on Europe. ell wantee to seee how you were and ty for the article. I have almost completed week 4, not doing too bad over all but did feel like quitting last week so still have rough days, I just hope it clears, can't imagine going through all this and then it not helping but then you've been there and you have to take the chance. Thasts the main reason why people try to see if they will be one of the few that it helps. wishh the research would move along a little faster but then its hard when you have a disease that affects you personally . Much more empathetic towards all diseases now, well take care and will talk to you later Suzy From: " Claudine Crews " <claudinecrews@...> Reply-Hepatitis Conelist Hepatitis Conelist Subject: Genotypes Explained Date: Tue, 28 Mar 2000 12:54:11 CST This has to be the best article I've seen that explains genotypes. You can actually understand! Genotypes Explained It is much easier to talk of the hepatitis C virus as if it is a single organism but in fact it is a range of viruses, similar enough to be called hepatitis C virus, yet different enough to be classified into subgroups. Viruses are microscopic and no person could ever see them with the naked eye. Indeed, HCV is so small that there’s been no confirmed actual sighting of it using any type of microscope yet developed (see Ed 17, p1). Consequently, a better way to understand the terms HCV ‘genotypes’ and ‘subtypes’ is to compare them to things that we can more readily relate to. Genotypes The group of birds we call ‘raptors’ (birds of prey) have evolved into different main types. Imagining raptors as being hepatitis C viruses, you could take one major raptor type, such as eagles, and imagine these as being one of HCV’s main types (genotypes). Subtypes But eagles as a group are made up of different sub types such as the American Bald Eagle and Australia’s Wedge Tailed Eagle and Sea Eagle. You could imagine each of these as being one of the HCV subtypes that make up an HCV genotype. Quasispecies Within each of above particular types of eagles, there are further differences. All Wedge Tailed Eagles, for example, differ from each other in regard to wing span, weight, colour, beak size, etc. Similarly, within a hepatitis C sub-type, individual viruses differ from each other ever so slightly. Such viral differences are not significant enough to form another sub-type but instead form what’s known as quasi-species. It is believed that within an HCV sub-type, several million quasispecies may exist. Scientists predict that people who have hepatitis C, have billions of actual viruses circulating within their body. Although there may be one or two predominant sub-types, the infection as a whole is not a single entity and is composed of many different quasispecies. Classifications Biologists are generally not known for creativity when it comes to naming things - hence hepatitis C virus. The most commonly used classification of hepatitis C virus has HCV divided into the following genotypes (main types): 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11. As we’ve highlighted, HCV genotypes can be broken down into sub-types, some of which include: 1a, 1b, 1c 2a, 2b, 2c 3a, 3b 4a, 4b, 4c, 4d, 4e 5a 6a 7a, 7b 8a, 8b 9a 10a 11a Genotype patterns It is believed that the hepatitis C virus has evolved over a period of several thousand years (see Ed 20, p7). This would explain the current general global patterns of genotypes and subtypes: 1a - mostly found in Nth & Sth America; also common in Australia 1b - mostly found in Europe and Asia. 2a - is the most common genotype 2 in Japan and China. 2b - is the most common genotype 2 in the US and Nthn Europe. 2c - the most common genotype 2 in Wstn and Sthn Europe. 3a - highly prevalent here in Australia (40% of cases) and Sth Asia. 4a - highly prevalent in Egypt 4c - highly prevalent in Central Africa 5a - highly prevalent only in Sth Africa 6a - restricted to Hong Kong, Macau and Vietnam 7a and 7b - common in Thailand 8a, 8b & 9a - prevalent in Vietnam 10a & 11a - found in Indonesia It’s believed that of the estimated 160,000 Australians with HCV, approx. 35% have subtype ‘1a’, 15% have ‘1b’, 7% have ‘2’, 35% have ‘3’ (mostly being 3a). The remaining people would have other genotypes. Genotype and treatment Current scientific belief is that factors such as duration of a person’s HCV infection, their HCV viral load, age, grade of liver inflammation or stage of fibrosis may play an important role in determining response to interferon treatment. Recent studies have suggested that a person’s HCV subtype (or subtypes) may influence their possible response to interferon, or interferon-ribavirin combination treatment. World-wide trials are being conducted which will soon shed more light on this belief. We’ll publish any reports as they come to hand. Info taken from Genotypes and Genetic Variation of Hepatitis C Virus by G. Maerterns & L. Stuyver, reviewed by Dr Greg Dore of the National Centre in HIV Epidemiology & Clinical Research. From The Hep C Review; Ed 23, December 1998; Harvey ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com ______________________________________________________ Get Your Private, Free Email at http://www.hotmail.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 29, 2000 Report Share Posted March 29, 2000 I have 3a and so far have cleared the virus after 11 mo of combo, and I live in the us, so go figure. Take care, Les Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2003 Report Share Posted April 8, 2003 The following comes from Hepatitis-Central. Genotypes Explained It is much easier to talk of the hepatitis C virus as if it is a single organism but in fact it is a range of viruses, similar enough to be called hepatitis C virus, yet different enough to be classified into subgroups. Viruses are microscopic and no person could ever see them with the naked eye. Indeed, HCV is so small that there's been no confirmed actual sighting of it using any type of microscope yet developed. Consequently, a better way to understand the terms HCV 'genotypes' and 'subtypes' is to compare them to things that we can more readily relate to. Genotypes The group of birds we call 'raptors' (birds of prey) have evolved into different main types. Imagining raptors as being hepatitis C viruses, you could take one major raptor type, such as eagles, and imagine these as being one of HCV's main types (genotypes). Subtypes But eagles as a group are made up of different sub types such as the American Bald Eagle and Australia's Wedge Tailed Eagle and Sea Eagle. You could imagine each of these as being one of the HCV subtypes that make up an HCV genotype. Quasispecies Within each of above particular types of eagles, there are further differences. All Wedge Tailed Eagles, for example, differ from each other in regard to wing span, weight, colour, beak size, etc. Similarly, within a hepatitis C sub-type, individual viruses differ from each other ever so slightly. Such viral differences are not significant enough to form another sub-type but instead form what's known as quasi-species. It is believed that within an HCV sub-type, several million quasispecies may exist. Scientists predict that people who have hepatitis C, have billions of actual viruses circulating within their body. Although there may be one or two predominant sub-types, the infection as a whole is not a single entity and is composed of many different quasispecies. Classifications Biologists are generally not known for creativity when it comes to naming things - hence hepatitis C virus. The most commonly used classification of hepatitis C virus has HCV divided into the following genotypes (main types): 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11. As we've highlighted, HCV genotypes can be broken down into sub- types, some of which include: 1a, 1b, 1c 2a, 2b, 2c 3a, 3b 4a, 4b, 4c, 4d, 4e 5a 6a 7a, 7b 8a, 8b 9a 10a 11a Genotype patterns It is believed that the hepatitis C virus has evolved over a period of several thousand years. This would explain the current general global patterns of genotypes and subtypes: 1a - mostly found in North & South America; also common in Australia 1b - mostly found in Europe and Asia. 2a - is the most common genotype 2 in Japan and China. 2b - is the most common genotype 2 in the US and Northern Europe. 2c - the most common genotype 2 in Western and Southern Europe. 3a - highly prevalent here in Australia (40% of cases) and South Asia. 4a - highly prevalent in Egypt 4c - highly prevalent in Central Africa 5a - highly prevalent only in South Africa 6a - restricted to Hong Kong, Macau and Vietnam 7a and 7b - common in Thailand 8a, 8b & 9a - prevalent in Vietnam 10a & 11a - found in Indonesia It's believed that of the estimated 160,000 Australians with HCV, approx. 35% have subtype '1a', 15% have '1b', 7% have '2', 35% have '3' (mostly being 3a). The remaining people would have other genotypes. Genotype and treatment Current scientific belief is that factors such as duration of a person's HCV infection, their HCV viral load, age, grade of liver inflammation or stage of fibrosis may play an important role in determining response to interferon treatment. Recent studies have suggested that a person's HCV subtype (or subtypes) may influence their possible response to interferon, or interferon-ribavirin combination treatment. World-wide trials are being conducted which will soon shed more light on this belief. We'll publish any reports as they come to hand. Genotypes and Genetic Variation of Hepatitis C Virus by G. Maerterns & L. Stuyver, reviewed by Dr Greg Dore of the National Centre in HIV Epidemiology & Clinical Research. From The Hep C Review; Ed 23, December 1998; Harvey Quote Link to comment Share on other sites More sharing options...
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