Guest guest Posted January 11, 2001 Report Share Posted January 11, 2001 Malic Acid Fibromyalgia Syndrome (fibromyalgia) is a condition which affects principally middle-aged women, characterized by a syndrome of generalized musculoskeletal pain, aches, stiffness, and tenderness at specific anatomical sites. This condition is considered primarily when there are no obvious causes. Since it was first described, fibromyalgia has become recognized as a fairly common rheumatic complaint with a clinical prevalence of 6 to 20%. Additionally, fibromyalgia has been associated with irritable bowel syndrome, tension headache, mitral valve prolapse, and Chronic Fatigue Syndrome. Numerous treatment modalities have been attempted to treat patients with fibromyalgia, but unfortunately the results have been poor, due to a lack of understanding of the condition's etiology. In recent years, evidence has accumulated to suggest that fibromyalgia is the result of local hypoxia to the muscles. For instance, patients with fibromyalgia have low muscle-tissue oxygen pressure in affected muscles, and to a lesser degree the same is true of other tissues. Muscle biopsies from affected areas showed muscle tissue glycolysis is inhibited, reducing ATP synthesis. This stimulates the process of gluconeogenesis, which results in muscle tissue breakdown and mitochondrial damage. Additionally, low levels of the high-energy phosphates ATP, ADP, and phosphocreatine were found. It is hypothesized that in hypoxic muscle tissue, glycolysis is inhibited, reducing ATP synthesis. This muscle tissue breakdown, which has been observed in muscle biopsies taken from fibromyalgia patients, is hypothesized to result in the muscle pain characteristic of fibromyalgia. Malic acid is both derived from food sources and synthesized in the body through the citric acid cycle. Its importance to the production of energy in the body during both aerobic and anaerobic conditions is well established. Under aerobic conditions, the oxidation of malate to oxaloacetate provides reducing equivalents to the mitochondria through the malateaspartate redox shuttle. During anaerobic conditions, where a buildup of excess of reducing equivalents inhibits glycolysis, malic acid's simultaneous reduction to succinate and oxidation to oxaloacetate is capable of removing the accumulating reducing equivalents. This allows malic acid to reverse hypoxia's inhibition of glycolysis and energy production, possibly improving energy production in fibromyalgia, and reversing the negative effect of the relative hypoxia that has been found in these patients. Because of its obvious relationship to energy depletion during exercise, malic acid may be of benefit to healthy individuals interested in maximizing their energy production, as well as those with Fibromyalgia, or Chronic Fatigue Syndrome. As a result of the compelling evidence that malic acid plays a central role in energy production, especially during hypoxic conditions, malic acid supplements have been examined for their effects on fibromyalgia. Subjective improvement in pain was observed within 48 hours of supplementation with 1200-2400 mg. of malic acid, and this improvement was lost following the discontinuation of malic acid for 48 hours. While these studies also used magnesium supplements, due to the fact that magnesium is often low in fibromyalgia patients, the rapid improvement following malic acid, as well as the rapid deterioration after discontinuation, suggests that malic acid is the most important component. This interesting theory of localized hypoxia in fibromyalgia, and the ability of malic acid to overcome the block in energy production that this causes, should provide hope for those afflicted with fibromyalgia. The potential for malic acid supplements however, reaches much farther than fibromyalgia. Additionally, many hypoxia-related conditions such as respiratory and circulatory insufficiency, are associated with deficient energy production. Therefore, malic acid supplements may be of benefit in these conditions. Chronic Fatigue Syndrome has also been found to be associated with fibromyalgia, and malic acid supplementation may be of use in improving energy production in this condition as well. Lastly, malic acid may be of use as a general supplement, ensuring an optimal level of malic acid within the cells, and thus, maintaining an optimal level of energy production. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 4, 2001 Report Share Posted May 4, 2001 e wrote:I just hate the thought of putting silicon into my body, no matter how small the amt, but it just seems that it is in everything!! So do any of you take any supplements which contain silica or silicon dioxide? Please let me know so I know whether I should return to sender, and order from another company. And does anyone know of a company that markets malic acid without the silica or silicon dioxide? Hi e, I watch carefully so that I don't take pills with that in it, but once in awhile I have missed it and have taken them. I have not noticed a terrible effect. However, if you really want to return the product and find something else, then you should. (If you got it from Vitaminshoppe.com, they will take it back no problem. The brand I have does not have silicon dioxide in it. It is Nature's Life Malic Acid, 800 mg, and it was $6.36 for 100 caps. Can't remember where I got it though, but it was here locally. Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 5, 2001 Report Share Posted May 5, 2001 Dear Patty: Does your brand have magnesium in it? Magnesium is important for fibromyalgia. . ----- Original Message ----- From: Patty Sent: Friday, May 04, 2001 12:49 AM Subject: Re: Malic acid e wrote:I just hate the thought of putting silicon into my body, no matter how small the amt, but it just seems that it is in everything!! So do any of you take any supplements which contain silica or silicon dioxide? Please let me know so I know whether I should return to sender, and order from another company. And does anyone know of a company that markets malic acid without the silica or silicon dioxide? Hi e, I watch carefully so that I don't take pills with that in it, but once in awhile I have missed it and have taken them. I have not noticed a terrible effect. However, if you really want to return the product and find something else, then you should. (If you got it from Vitaminshoppe.com, they will take it back no problem. The brand I have does not have silicon dioxide in it. It is Nature's Life Malic Acid, 800 mg, and it was $6.36 for 100 caps. Can't remember where I got it though, but it was here locally. Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 5, 2001 Report Share Posted May 5, 2001 Dear Dr. Kolb, My daughter, Arden, is a WHCNP, and 'one of us'! She's done much research over the past 6-7 years, and has come to the conclusion that Silicon & Silica are OK, in the 'gut', and pass through in a brief period of time. Do you agree, or disagree with her conclusions, as she has little time for research work these days? She also experiments on herself to come to many of her conclusions regarding these matters. Her reasoning may make more sense to me since I'm her mother, however, her reasoning has proven true for me -- I think! Blessings, Martha M. NSIF Martha Murdock, DirectorNational Silicone Implant FoundationDallas, Texas Headquarters ----- Original Message ----- From: Dr. Kolb Sent: Saturday, May 05, 2001 12:31 AM Subject: Re: Malic acid Dear Patty: Does your brand have magnesium in it? Magnesium is important for fibromyalgia. . ----- Original Message ----- From: Patty Sent: Friday, May 04, 2001 12:49 AM Subject: Re: Malic acid e wrote:I just hate the thought of putting silicon into my body, no matter how small the amt, but it just seems that it is in everything!! So do any of you take any supplements which contain silica or silicon dioxide? Please let me know so I know whether I should return to sender, and order from another company. And does anyone know of a company that markets malic acid without the silica or silicon dioxide? Hi e, I watch carefully so that I don't take pills with that in it, but once in awhile I have missed it and have taken them. I have not noticed a terrible effect. However, if you really want to return the product and find something else, then you should. (If you got it from Vitaminshoppe.com, they will take it back no problem. The brand I have does not have silicon dioxide in it. It is Nature's Life Malic Acid, 800 mg, and it was $6.36 for 100 caps. Can't remember where I got it though, but it was here locally. Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 6, 2001 Report Share Posted May 6, 2001 Dear Martha: I agree and if you look at most medicines they contain these ingredients. I will ask some of the experts in holistic medicine that we interview on the TV and radio shows as well. . ----- Original Message ----- From: MARTHA Sent: Saturday, May 05, 2001 2:23 AM Subject: Re: Malic acid Dear Dr. Kolb, My daughter, Arden, is a WHCNP, and 'one of us'! She's done much research over the past 6-7 years, and has come to the conclusion that Silicon & Silica are OK, in the 'gut', and pass through in a brief period of time. Do you agree, or disagree with her conclusions, as she has little time for research work these days? She also experiments on herself to come to many of her conclusions regarding these matters. Her reasoning may make more sense to me since I'm her mother, however, her reasoning has proven true for me -- I think! Blessings, Martha M. NSIF Martha Murdock, DirectorNational Silicone Implant FoundationDallas, Texas Headquarters ----- Original Message ----- From: Dr. Kolb Sent: Saturday, May 05, 2001 12:31 AM Subject: Re: Malic acid Dear Patty: Does your brand have magnesium in it? Magnesium is important for fibromyalgia. . ----- Original Message ----- From: Patty Sent: Friday, May 04, 2001 12:49 AM Subject: Re: Malic acid e wrote:I just hate the thought of putting silicon into my body, no matter how small the amt, but it just seems that it is in everything!! So do any of you take any supplements which contain silica or silicon dioxide? Please let me know so I know whether I should return to sender, and order from another company. And does anyone know of a company that markets malic acid without the silica or silicon dioxide? Hi e, I watch carefully so that I don't take pills with that in it, but once in awhile I have missed it and have taken them. I have not noticed a terrible effect. However, if you really want to return the product and find something else, then you should. (If you got it from Vitaminshoppe.com, they will take it back no problem. The brand I have does not have silicon dioxide in it. It is Nature's Life Malic Acid, 800 mg, and it was $6.36 for 100 caps. Can't remember where I got it though, but it was here locally. Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 6, 2001 Report Share Posted May 6, 2001 Hi Dr. , Thanks for your response, and I have forwarded this to Arden. Would you please add her to your Professional E-Mail List? Many thanks, as always, MM / NSIF Martha Murdock, DirectorNational Silicone Implant FoundationDallas, Texas Headquarters ----- Original Message ----- From: Dr. Kolb Sent: Saturday, May 05, 2001 10:24 PM Subject: Re: Malic acid Dear Martha: I agree and if you look at most medicines they contain these ingredients. I will ask some of the experts in holistic medicine that we interview on the TV and radio shows as well. . ----- Original Message ----- From: MARTHA Sent: Saturday, May 05, 2001 2:23 AM Subject: Re: Malic acid Dear Dr. Kolb, My daughter, Arden, is a WHCNP, and 'one of us'! She's done much research over the past 6-7 years, and has come to the conclusion that Silicon & Silica are OK, in the 'gut', and pass through in a brief period of time. Do you agree, or disagree with her conclusions, as she has little time for research work these days? She also experiments on herself to come to many of her conclusions regarding these matters. Her reasoning may make more sense to me since I'm her mother, however, her reasoning has proven true for me -- I think! Blessings, Martha M. NSIF Martha Murdock, DirectorNational Silicone Implant FoundationDallas, Texas Headquarters ----- Original Message ----- From: Dr. Kolb Sent: Saturday, May 05, 2001 12:31 AM Subject: Re: Malic acid Dear Patty: Does your brand have magnesium in it? Magnesium is important for fibromyalgia. . ----- Original Message ----- From: Patty Sent: Friday, May 04, 2001 12:49 AM Subject: Re: Malic acid e wrote:I just hate the thought of putting silicon into my body, no matter how small the amt, but it just seems that it is in everything!! So do any of you take any supplements which contain silica or silicon dioxide? Please let me know so I know whether I should return to sender, and order from another company. And does anyone know of a company that markets malic acid without the silica or silicon dioxide? Hi e, I watch carefully so that I don't take pills with that in it, but once in awhile I have missed it and have taken them. I have not noticed a terrible effect. However, if you really want to return the product and find something else, then you should. (If you got it from Vitaminshoppe.com, they will take it back no problem. The brand I have does not have silicon dioxide in it. It is Nature's Life Malic Acid, 800 mg, and it was $6.36 for 100 caps. Can't remember where I got it though, but it was here locally. Patty Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 6, 2001 Report Share Posted May 6, 2001 Hi , No, Nature's Life brand Malic Acid does not include magnesium in the malic acid as a supplement, only as magnesium stearate, the filler. I have never had pain to the extent that others have described. When I first got implants, I remember how awful my legs ached for about 2 weeks, but it went away and never came back. I do not believe that I have fibromyalgia, but I do take magnesium supplements on occasion. Patty ----- Original Message ----- From: Dr. Kolb Sent: Friday, May 04, 2001 10:31 PM Subject: Re: Malic acid Dear Patty: Does your brand have magnesium in it? Magnesium is important for fibromyalgia. . ----- Original Message ----- From: Patty Sent: Friday, May 04, 2001 12:49 AM Subject: Re: Malic acid e wrote:I just hate the thought of putting silicon into my body, no matter how small the amt, but it just seems that it is in everything!! So do any of you take any supplements which contain silica or silicon dioxide? Please let me know so I know whether I should return to sender, and order from another company. And does anyone know of a company that markets malic acid without the silica or silicon dioxide? Hi e, I watch carefully so that I don't take pills with that in it, but once in awhile I have missed it and have taken them. I have not noticed a terrible effect. However, if you really want to return the product and find something else, then you should. (If you got it from Vitaminshoppe.com, they will take it back no problem. The brand I have does not have silicon dioxide in it. It is Nature's Life Malic Acid, 800 mg, and it was $6.36 for 100 caps. Can't remember where I got it though, but it was here locally. Patty Quote Link to comment Share on other sites More sharing options...
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