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Re: t4 and t3 vs armour

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Let us not forget that one can easily add in the exact/desired amount of T3

(cytomel) to any T4 med to get the ration of t4 to T3 that works its magic.

Armour and Thyrolar are predetermined ratios that are not even close to what

a human thyriod produces.

And excess T3 is very hard on the heart.

Just another angle from someone who has successfully taken Levoxyl combined

with Cytomel for about 5 years.

Sue

On 10/11/08 7:42 PM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> Hi Pamela,

>

>

> All of the medical texts including the CMDT (Current Medical Diagnosis

> & Treatment) Manual suggest levothyroxine as the preferred treatment

> because the dose is more uniform, but I don't buy it. Manufacturing

> processes to synthesize chemicals can be patented, and it is probably

> a more profitable product than Armour thyroid. There is a synthetic

> product that holds a lot of promise made by Forest Pharmaceuticals,

> the same folks that make Armour. That is Thyrolar. It is a mix of

> T3 & T4 at a ratio of 1:4. Armour is 1:4.22. It doesn't have calcitonin

> or T2 & T1, but it doesn't rely on the bodies capacity to convert T4

> to T3 as heavily as a pure T4 product. It certainly looks promising.

> You might ask your doctor about it if you are not responding well

> to a T4 only product. Of course, there is Armour, the old standby.

> I am doing very well on it and it is readily available. My doctor

> prescribed Armour for me, but some times she is slow in making

> dose changes, and she prescribes 1 large dose pill. I do better

> taking it throughout the day. It helps to eliminate the afternoon

> dip in my energy level.

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That is true, but it can be hard to get a doctor to prescribe

a T3 only product, thanks to abuse in the sports community.

Excessive doses of any thyroid product are hard on the heart.

T4 is no different. It converts to T3, so if you get too much

of it in your system, you are in effect overdosing on T3 anyway.

>

> >

> >

> >

> > Hi Pamela,

> >

> >

> > All of the medical texts including the CMDT (Current Medical Diagnosis

> > & Treatment) Manual suggest levothyroxine as the preferred treatment

> > because the dose is more uniform, but I don't buy it. Manufacturing

> > processes to synthesize chemicals can be patented, and it is probably

> > a more profitable product than Armour thyroid. There is a synthetic

> > product that holds a lot of promise made by Forest Pharmaceuticals,

> > the same folks that make Armour. That is Thyrolar. It is a mix of

> > T3 & T4 at a ratio of 1:4. Armour is 1:4.22. It doesn't have calcitonin

> > or T2 & T1, but it doesn't rely on the bodies capacity to convert T4

> > to T3 as heavily as a pure T4 product. It certainly looks promising.

> > You might ask your doctor about it if you are not responding well

> > to a T4 only product. Of course, there is Armour, the old standby.

> > I am doing very well on it and it is readily available. My doctor

> > prescribed Armour for me, but some times she is slow in making

> > dose changes, and she prescribes 1 large dose pill. I do better

> > taking it throughout the day. It helps to eliminate the afternoon

> > dip in my energy level.

>

>

>

>

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Mike, you might have midunderstood ­ I did not say prescribe T3 only

product.

I said t4 WITH t3 and it¹s quite common.

I have had 3 out 3 docs recommend it so far...

Also, not all of us convert t4 to t3 very well at all and t4 is no where

near as harmful as excess t3 is.

sue

On 10/11/08 8:12 PM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> That is true, but it can be hard to get a doctor to prescribe

> a T3 only product, thanks to abuse in the sports community.

>

> Excessive doses of any thyroid product are hard on the heart.

> T4 is no different. It converts to T3, so if you get too much

> of it in your system, you are in effect overdosing on T3 anyway.

>

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Cite your source. :-)

Just kidding. I do take exception to the statement that too

much T4 is less dangerous than too much T3. That is only

true for people that don't convert T4 to T3 very well. Most

people do, and having excess T4 convert to T3 is a common

cause of thyrotoxicosis which does increase the chances

of having a stroke or heart attack. T4 is T3 with an extra

iodine attached. It doesn't matter if the T3 came from T4

or a T3 only med, it's all the same. The only difference is

you can induce vomiting or administer charcoal to soak

up excess T3 if it is still in the digestive tract. If it is

coming from excess T4 hanging around the body, more

drastic measures have to be taken to manage it. It has

a half life of a week, so it stays in the system a lot longer

than T3. It only has a half life of 24 hours. If you've

overdosed on T4, you are in for a ride of several days

instead of several hours.

>

> >

> >

> >

> > That is true, but it can be hard to get a doctor to prescribe

> > a T3 only product, thanks to abuse in the sports community.

> >

> > Excessive doses of any thyroid product are hard on the heart.

> > T4 is no different. It converts to T3, so if you get too much

> > of it in your system, you are in effect overdosing on T3 anyway.

> >

>

>

>

>

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Any overdose of any med is harmful, obviiously.

But ‹T3 is harder on the heart even when NOT over-dosing.

It goes to work much more quickly and is 4x as potent as T4.

I am not even talking about overdosing to the point of needing to vomit.

I am talking about not having a proper t4/t3 ratio to reach healthy thryoid

levels.

Sue

On 10/11/08 10:43 PM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> Cite your source. :-)

>

> Just kidding. I do take exception to the statement that too

> much T4 is less dangerous than too much T3. That is only

> true for people that don't convert T4 to T3 very well. Most

> people do, and having excess T4 convert to T3 is a common

> cause of thyrotoxicosis which does increase the chances

> of having a stroke or heart attack. T4 is T3 with an extra

> iodine attached. It doesn't matter if the T3 came from T4

> or a T3 only med, it's all the same. The only difference is

> you can induce vomiting or administer charcoal to soak

> up excess T3 if it is still in the digestive tract. If it is

> coming from excess T4 hanging around the body, more

> drastic measures have to be taken to manage it. It has

> a half life of a week, so it stays in the system a lot longer

> than T3. It only has a half life of 24 hours. If you've

> overdosed on T4, you are in for a ride of several days

> instead of several hours.

>

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If your T3 is within reference range, you are not overdosed

and it is not hard on your heart.

If you take too much T4, you don't even know you are overdosed

for days, and once you do, it takes days to come back down from

that. T4 is delayed action T3. Taking too much T4 is taking too

much T3, you just don't find out about it for a few days.

Different people may feel better on different ratios of T4/T3,

largely dependent on their ability to convert T4 to T3. 1:4 or 1:4.22

just happen to be a good starting place. Any hormone replacement

regimen should be backed up by labs. If the ratio of T4 to T3 in Armour

results in your free T3 being out of reference range, absolutely, it

will be hard on the heart.

>

> Any overdose of any med is harmful, obviiously.

> But ‹T3 is harder on the heart even when NOT over-dosing.

> It goes to work much more quickly and is 4x as potent as T4.

>

> I am not even talking about overdosing to the point of needing to vomit.

> I am talking about not having a proper t4/t3 ratio to reach healthy thryoid

> levels.

>

> Sue

>

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Mike, we will just have to agree to disagree.

T3 is actually hard on the heart, even on the Œright dose¹.

It¹s also bad for adrenal glands. It stimulates adrenaline which taxes the

adrenals.

But that¹s about all I can say on this topic thus many doctor¹s wont as you

say, prescirbe it.

They really aren¹t being stupid, they know it¹s hard on the heart.

But hey, I take some, in low doses, because it helps me right now...down the

road I hope to eliminate if if I can find a way to convert t4 to t3 better.

sue

On 10/12/08 9:04 PM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> If your T3 is within reference range, you are not overdosed

> and it is not hard on your heart.

>

> If you take too much T4, you don't even know you are overdosed

> for days, and once you do, it takes days to come back down from

> that. T4 is delayed action T3. Taking too much T4 is taking too

> much T3, you just don't find out about it for a few days.

>

> Different people may feel better on different ratios of T4/T3,

> largely dependent on their ability to convert T4 to T3. 1:4 or 1:4.22

> just happen to be a good starting place. Any hormone replacement

> regimen should be backed up by labs. If the ratio of T4 to T3 in Armour

> results in your free T3 being out of reference range, absolutely, it

> will be hard on the heart.

>

>

>> >

>> > Any overdose of any med is harmful, obviiously.

>> > But ‹T3 is harder on the heart even when NOT over-dosing.

>> > It goes to work much more quickly and is 4x as potent as T4.

>> >

>> > I am not even talking about overdosing to the point of needing to vomit.

>> > I am talking about not having a proper t4/t3 ratio to reach healthy thryoid

>> > levels.

>> >

>> > Sue

>> >

>

>

>

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That's fine Sue. I still like you. :-) If you want to convince

me, show me peer reviewed documentation and I can certainly

be swayed. For now, I'm just going with everything the information

that I'm getting out of medical text books and such.

-Mike :-)

>

> Mike, we will just have to agree to disagree.

> T3 is actually hard on the heart, even on the Œright dose¹.

> It¹s also bad for adrenal glands. It stimulates adrenaline which taxes the

> adrenals.

> But that¹s about all I can say on this topic thus many doctor¹s wont as you

> say, prescirbe it.

> They really aren¹t being stupid, they know it¹s hard on the heart.

> But hey, I take some, in low doses, because it helps me right now...down the

> road I hope to eliminate if if I can find a way to convert t4 to t3 better.

>

> sue

>

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That¹s a pretty big change for you :)

Used to be when you relied on a lot more than medical textbooks and such.

Sigh :-)

I got my info from the Schwarzbein Priniciple Ii: Transition; my endo; my

nutritioinist and from my GP. Yet I am still a big proponent for using T3 in

smaller doses. That¹s just my way. Yours works for you ­ and that¹s all we

can do.

I still like you too ;-)

is released.

On 10/13/08 11:34 AM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> That's fine Sue. I still like you. :-) If you want to convince

> me, show me peer reviewed documentation and I can certainly

> be swayed. For now, I'm just going with everything the information

> that I'm getting out of medical text books and such.

>

> -Mike :-)

>

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T3 acts directly on vascular smooth muscle to relax it and decrease systemic

vascular resistance. The kidney senses a decrease in effective arterial

volume and activates the renin-angiotensin-aldosterone system, leading to

expansion of plasma volume. The end result is an elevated systolic

pressure, a decreased diastolic pressure, with a widened pulse pressure and

expanded plasma volume (see Klein NEJM 2001).

T3 also has a direct effect on transcription in the cardiac myocyte, leading

to increased expression of many genes that enhance cardiac contractility,

most notably myosin alpha chains and SERCA-2 (a sarcolemmal calcium

channel).

http://www.clinicalcorrelations.org/?p=878

In addition, the use of T3 may cause disturbances in heart rhythms. Some

patients treated only with thyroxine continue to have mood and memory

problems or other symptoms.

Combination products containing T4 and T3, such as liotrix (Thyrolar), are

available, but there is some controversy concerning their benefits.

http://health.nytimes.com/health/guides/disease/chronic-thyroiditis-hashimot

os-disease/treatment.html

Thyroid Drugs: The Controversy Over T3

I asked Dr. Sinatra if he felt that the use of T3 was a danger to the heart,

as some doctors claim. With some patients, Dr. Sinatra is particularly

cautious. " For a woman with heart disease or active angina, T3 can be a

problem. It can make the heart work harder. Under those circumstances I

would hold back T3. "

http://thyroid.about.com/cs/expertinterviews/a/sinatra.htm

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I agree with you that small doses of T3 are OK, whether

it comes from a product that also has T4, or as a stand

alone product. I think that the reason that Thyrolar

and Armour are in that 1:4 region is that people that

don't respond to a T4 only treatment obviously have

a problem converting T4 to T3, so they make it more

T3 heavy than a normal body would produce. People

that are doing fine on a T4 only product are good at

converting T4 to T3. I also agree that 1:4 or 1:4.22 may

not be the best ratio for anyone because some people

might be between these two cases.

I am still relying on medical books. I've had some trouble

getting to good peer reviewed articles of substance

because I'm not a doctor and don't a membership

with some of these services.

I see more data online all the time. That's great. The

high tide floats all boats, and I really like to see the

tide of knowledge rising.

-Mike

>

> That¹s a pretty big change for you :)

>

> Used to be when you relied on a lot more than medical textbooks and such.

> Sigh :-)

>

>

> I got my info from the Schwarzbein Priniciple Ii: Transition; my endo; my

> nutritioinist and from my GP. Yet I am still a big proponent for using T3 in

> smaller doses. That¹s just my way. Yours works for you ­ and that¹s all we

> can do.

>

> I still like you too ;-)

> is released.

>

>

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That is good info.

The thing that you keep overlooking is that for most people,

a significant portion of their T4 converts to T3 so everything

you are saying about T3 also applies to T4.

If you are a person that absolutely can not convert T4 to T3,

these arguments are true, but that is not the norm.

>

> T3 acts directly on vascular smooth muscle to relax it and decrease systemic

> vascular resistance. The kidney senses a decrease in effective arterial

> volume and activates the renin-angiotensin-aldosterone system, leading to

> expansion of plasma volume. The end result is an elevated systolic

> pressure, a decreased diastolic pressure, with a widened pulse pressure and

> expanded plasma volume (see Klein NEJM 2001).

>

> T3 also has a direct effect on transcription in the cardiac myocyte, leading

> to increased expression of many genes that enhance cardiac contractility,

> most notably myosin alpha chains and SERCA-2 (a sarcolemmal calcium

> channel).

>

> http://www.clinicalcorrelations.org/?p=878

>

>

> In addition, the use of T3 may cause disturbances in heart rhythms. Some

> patients treated only with thyroxine continue to have mood and memory

> problems or other symptoms.

>

> Combination products containing T4 and T3, such as liotrix (Thyrolar), are

> available, but there is some controversy concerning their benefits.

>

> http://health.nytimes.com/health/guides/disease/chronic-thyroiditis-hashimot

> os-disease/treatment.html

>

>

> Thyroid Drugs: The Controversy Over T3

>

> I asked Dr. Sinatra if he felt that the use of T3 was a danger to the heart,

> as some doctors claim. With some patients, Dr. Sinatra is particularly

> cautious. " For a woman with heart disease or active angina, T3 can be a

> problem. It can make the heart work harder. Under those circumstances I

> would hold back T3. "

> http://thyroid.about.com/cs/expertinterviews/a/sinatra.htm

>

>

>

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I am speaking only specifically of adding T3 to what one¹s body already

makes as those cited studies show.

What our bodies do will be ³normal² unless something goes askew....

I know my BP goes up when I take the Cytomel ‹ but I still take it :(

I am taking the known risks into hand when I accept the Rx but as mentioned,

once I get my exercise program where it needs to be and my adrenals back up

and running, I shouldn¹t need to take that risk and supplement my body¹s own

T3 process.

Sue

On 10/13/08 12:00 PM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> That is good info.

>

> The thing that you keep overlooking is that for most people,

> a significant portion of their T4 converts to T3 so everything

> you are saying about T3 also applies to T4.

>

> If you are a person that absolutely can not convert T4 to T3,

> these arguments are true, but that is not the norm.

>

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I don't have a problem with any of that. The only point

I disagree on is that taking an excess of T4 will get you

to exactly the same point as taking an excess of T3.

That excess T4 will become an excess of T3 at some

point. It takes days to build up an excess of T4,

but it also takes days to clear it.

There is the matter of rT3, but it takes quite a while for

the body to exhibit that response.

>

> >

> >

> >

> > That is good info.

> >

> > The thing that you keep overlooking is that for most people,

> > a significant portion of their T4 converts to T3 so everything

> > you are saying about T3 also applies to T4.

> >

> > If you are a person that absolutely can not convert T4 to T3,

> > these arguments are true, but that is not the norm.

> >

>

>

>

>

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I believe because the T3 works so much faster, some doctors see it as more

potentially harmful, whereas the T4 is slower acting, metabolized...?

How the heck does one get a Reverse T3 test?

I asked for one but the lab didn¹t have one listed... It was labcorp.

I have read they are extremely rarely done cuz it¹s extremely rare to have a

reverse t3 problem but if I don¹t take T3, aka Cytomel, my Free t3 is just

10 pts inside of low end ³normal² on a range of 230-420.

sue

On 10/13/08 6:37 PM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> I don't have a problem with any of that. The only point

> I disagree on is that taking an excess of T4 will get you

> to exactly the same point as taking an excess of T3.

> That excess T4 will become an excess of T3 at some

> point. It takes days to build up an excess of T4,

> but it also takes days to clear it.

>

> There is the matter of rT3, but it takes quite a while for

> the body to exhibit that response.

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Mike, that's only true if T4/T3 conversion rates correlate to the half

lives of each. I think. Is this in fact the case?

..

..

> If you take too much T4, you don't even know you are overdosed

> for days, and once you do

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That's my point exactly. T3 has a half life of 24 hours and T4

is a week to 10 days I believe. It can take you a week or two

to discover that you are taking too much T4. By then, the levels

are very high and the portion that is being converted to T3 is

correspondingly high. When that portion gets above the reference

range, look out. You've got a week or more of hyper symptoms

while the excess T4 clears.

That's really the only point I was trying to make. All of the studies

about the action of excess T3 on the body also hold true for

excess T4. It just takes longer to get there and get back from

there with T4.

>

> I believe because the T3 works so much faster, some doctors see it as more

> potentially harmful, whereas the T4 is slower acting, metabolized...?

>

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The conversion rate is linear as far as I know. When I get a

chance to go on a reading jag again, I'll verify that.

The issue is that the slower half life of T4 means that levels

rise and fall much slower. If you accidentally take a few mcg

too much of T3, your heart is only pounding for a day or so.

If you build up too much T4 in the system, the T3 conversion

product can keep your heart pounding for days.

>

> Mike, that's only true if T4/T3 conversion rates correlate to the half

> lives of each. I think. Is this in fact the case?

>

>

> .

> .

>

>

> > If you take too much T4, you don't even know you are overdosed

> > for days, and once you do

>

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Are you saying that the T3 in a healthy person's body is unhealthy; or

maybe just that taken as a medicine? Or what?

..

..

>

> Posted by: " eastodurango@... "

> eastodurango@...

>

<mailto:eastodurango@...?Subject=%20Re%3A%20t4%20and%20t3%20vs%20armou\

r>

> jesse11111111111 <jesse11111111111>

>

>

> Mon Oct 13, 2008 8:08 am (PDT)

>

> Mike, we will just have to agree to disagree.

> T3 is actually hard on the heart, even on the Œright dose¹.

> It¹s also bad for adrenal glands. It stimulates adrenaline which taxes the

> adrenals.

> But that¹s about all I can say on this topic thus many doctor¹s wont

> as you

> say, prescirbe it.

> They really aren¹t being stupid, they know it¹s hard on the heart.

> But hey, I take some, in low doses, because it helps me right

> now...down the

> road I hope to eliminate if if I can find a way to convert t4 to t3

> better.

>

> sue

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One more time and I am done:

People who have compromised ADRENAL GLANDS should not take t3.

People who do not have hypo should not take t3

People who do have hypo should take t3 with caution.

I gave 3 cited sources.

I am really done -- you guys can keep kicking it around.

sue

On 10/13/08 8:24 PM, " " <res075oh@...> wrote:

> Are you saying that the T3 in a healthy person's body is unhealthy; or

> maybe just that taken as a medicine? Or what?

>

>

> .

> .

>

>>

>> Posted by: " eastodurango@... "

>> eastodurango@...

>>

>> <mailto:eastodurango@...?Subject=%20Re%3A%20t4%20and%20t3%20vs%20ar

>> mour>

>> jesse11111111111 <jesse11111111111>

>>

>>

>> Mon Oct 13, 2008 8:08 am (PDT)

>>

>> Mike, we will just have to agree to disagree.

>> T3 is actually hard on the heart, even on the Œright dose¹.

>> It¹s also bad for adrenal glands. It stimulates adrenaline which taxes the

>> adrenals.

>> But that¹s about all I can say on this topic thus many doctor¹s wont

>> as you

>> say, prescirbe it.

>> They really aren¹t being stupid, they know it¹s hard on the heart.

>> But hey, I take some, in low doses, because it helps me right

>> now...down the

>> road I hope to eliminate if if I can find a way to convert t4 to t3

>> better.

>>

>> sue

>

>

> ------------------------------------

>

>

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People who take armour are by nature taking too much t3 every day not just

for a day or two. The ratio is much higher than what a human makes.

Over and out on the t3 issue.

sue

On 10/13/08 8:22 PM, " Mike Lawson " <mlawson66@...> wrote:

>

>

>

> The conversion rate is linear as far as I know. When I get a

> chance to go on a reading jag again, I'll verify that.

>

> The issue is that the slower half life of T4 means that levels

> rise and fall much slower. If you accidentally take a few mcg

> too much of T3, your heart is only pounding for a day or so.

> If you build up too much T4 in the system, the T3 conversion

> product can keep your heart pounding for days.

>

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Mike,

You wrote:

>

> The conversion rate is linear as far as I know....

Conversion rate is proportional to concentration, which results in the

exponential decay curve. However, this deviates at the extremes. HypoT

makes the half lives a bit longer. HyperT speeds them up.

Chuck

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Thanks Chuck, where can I find out more about this?

-Mike

> >

> > The conversion rate is linear as far as I know....

>

> Conversion rate is proportional to concentration, which results in the

> exponential decay curve. However, this deviates at the extremes. HypoT

> makes the half lives a bit longer. HyperT speeds them up.

>

> Chuck

>

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Mike,

You wrote:

> Thanks Chuck, where can I find out more about this?

There are lots of papers out there on this, but you need to be careful. Many of

the position papers cite a half life for T3 of 8 hours instead of 24, but that

was measured in Sprague Dawley rats. Some of the experts get this confused, as

Sheila can attest. When measured in hypoT people, the T3 half life is more like

48 hours. When euthyroid, it is about 24 hours. There is much more agreement on

T4, which evidently is about 6.7 days.

The principal mechanism for removal of T4 is deiodination to T3. The same

enzymes are responsible for changing T3 and RT3 into T2. So, the conversion rate

is proportional to the product of the concentrations of T4 and the enzyme.

This is equivalent in radioactive decay to saying the decay rate is proportional

to the amount (number of atoms) present. In math terms:

dN/dt = -kN . N is number of atoms or concentration of T4.

Integrate to get N(t) = N(t=0) exp(-kt) .

The mean life 1/k is connected to half life by k = ln2 / T1/2 .

With this simple relationship, they can determine the half life of T4 by

plotting serum concentrations (in a thyroidectomized animal or person) on a

semilog plot versus time. The slope is k.

Chuck

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That's what I thought too. But then you have the people who swear that

they don't feel good unless they take 5 or 6 grains of Armour every

day. I don't really know how to fit them into the equation.

BTW, I'm not trying to bug you; just learn and understand.

..

..

> Posted by: " eastodurango@... "

> eastodurango@...

>

<mailto:eastodurango@...?Subject=%20Re%3A%20t4%20and%20t3%20vs%20armou\

r>

> jesse11111111111 <jesse11111111111>

>

>

> Mon Oct 13, 2008 6:32 pm (PDT)

>

> People who take armour are by nature taking too much t3 every day not just

> for a day or two. The ratio is much higher than what a human makes.

> Over and out on the t3 issue.

>

> sue

>

> On 10/13/08 8:22 PM, " Mike Lawson " <mlawson66@...

> <mailto:mlawson66%40comcast.net>> wrote:

>

> >

> >

> >

> > The conversion rate is linear as far as I know. When I get a

> > chance to go on a reading jag again, I'll verify that.

> >

> > The issue is that the slower half life of T4 means that levels

> > rise and fall much slower. If you accidentally take a few mcg

> > too much of T3, your heart is only pounding for a day or so.

> > If you build up too much T4 in the system, the T3 conversion

> > product can keep your heart pounding for

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