Guest guest Posted December 14, 2007 Report Share Posted December 14, 2007 I'm not sure how long it lasts, but when I take my dose around 7:30 am, I start to feel a definite down around 4 or 5 pm. I don't think taking more would make it last longer. I would think it is what it is. Roni AthleticItaliano@... wrote: Anyone know how long a dose of Cytomel works (stays active?) If you are taking more of it will it last longer in your system? Thanks! AJ **************************************See AOL's top rated recipes (http://food.aol.com/top-rated-recipes?NCID=aoltop00030000000004) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 14, 2007 Report Share Posted December 14, 2007 AthleticItaliano@... wrote: > > > > Anyone know how long a dose of Cytomel works (stays active?) If you are > taking more of it will it last longer in your system? The concentration of T3 in your blood will reach a peak about an hour after you take it. From there, the concentration will steadily decrease until about half of the peak level is reached after 24 hours. Consequently, we say it has a biological half life of about one day. The problem with this simple model of T3 kinetics, is that more than 99% of the T3 is bound by albumin and globulin. As such, it is unavailable to function as Free T3 until it is released from binding. The FT3 fraction has a shorter effective half life than the bound. Together they have a composite half life of one day, but the FT3 really has a shorter half life than the remainder, so the bound T3 is effectively " stored " in the blood. Some is metabolized, while some is freed and then metabolized to produce a composite half life of a day. Only the FT3 is effective, and the binding process effectively " throttles " the availability of T3 for its function. This " evens out " the effect of taking a dose for several hours, after which it resumes the obvious decline. Therefore dividing your doses into at most 8 hour segments is needed to deliver a level benefit. If you take more in any one dose, you reach a higher peak at one hour and more is present at the one day point, but the half life is still one day. Chuck Quote Link to comment Share on other sites More sharing options...
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