Guest guest Posted April 27, 2007 Report Share Posted April 27, 2007 I believe Hashimotos is a dominant, or can be an incomplete dominant (as I think it is in my case). I can also tell you from personal experience that kids often will not listen when you tell them they can have it. Actually, my older son had a physical last month. I asked him to ask his doctor for a thyroid check as well--Ft3, FT4 as well as the usual TSH. He emailed to tell em his results were back, and the Dr. tells him his thyroid is fine. The boy will not ask his Dr. for the actual numbers. Plus I would bet $'s, he only got TSH. For that matter, my own mother told me 25 years ago that I ought to get a thyroid check because I had a roll of fat around the base of my neck. I blew her off at the time. However, when I finally figured out four years ago that she was right, I phoned her and told her she was right all along. :-) Gail > > I just found out today that my younger sister (16 years old) was just diagnosed with hashimoto's thyroiditis. I had read that there may be a hereditary factor but it has proven to be very strong in my family. My Mom has Hashimoto's and I was diagnosed a few months ago and we decided to get my sister checked just in case and lo and behold- she has it too. Her TSH right now is only 5.07 but I am soooo glad we caught it in the early stages unlike what I had to go through (TSH 43) :-( Hmm, I'm not totally sure why I'm telling this story ... I'm just really happy we got her diagnosed so soon I guess :-) Maybe this can be a reminder to people who have Hashi's to get their kids tested for it no matter how old they are. > > <3 > ______________________________________________________________________ __ > AOL now offers free email to everyone. Find out more about what's free from AOL at AOL.com. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 27, 2007 Report Share Posted April 27, 2007 Gail, You wrote: > > > I believe Hashimotos is a dominant, or can be an incomplete dominant > (as I think it is in my case).... Autosomal dominance certainly accounts for a large percentage, but there is probably more than one etiology, including multiple genes and perhaps interacting models with both dominant and recessive traits. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 27, 2007 Report Share Posted April 27, 2007 I don't think so. One disease, Hoshimotos, one mode of inheritance. It doesn't make sense to me that it could be polygenic, as that would show up as varying degrees of hypoT--like hip dysplasia in dogs. I can see where people might think it a recessive. I'm reasonably certain that neither of my parents has it. However, I think my mother has it, actually as a dominant with incomplete penetrance. So it hasn't shown up in her. I also think that there are many people who have it, but have not been diagnosed--like my maternal grandmother, who had my symptoms. She died of it, undiagnosed. In fact, nobody on either side of my family, as far back as I am aware, has ever been diagnosed hypoT. That might indicate recessive. But I'm sure it was there alright. In dogs there's currently DNA research going on to find automimmune thyroiditis. It's currenty thought to be recessive by most. I'm betting they will find it's dominant with incomplete penetrance. Gail In hypothyroidism , Chuck B <gumboyaya@...> wrote: > > Gail, > > You wrote: > > > > > > I believe Hashimotos is a dominant, or can be an incomplete dominant > > (as I think it is in my case).... > > Autosomal dominance certainly accounts for a large percentage, but there > is probably more than one etiology, including multiple genes and perhaps > interacting models with both dominant and recessive traits. > > Chuck > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 28, 2007 Report Share Posted April 28, 2007 & Gail on wrote: > > > I don't think so. One disease, Hoshimotos, one mode of inheritance. It > doesn't make sense to me that it could be polygenic, as that would show > up as varying degrees of hypoT--like hip dysplasia in dogs. They have identified over 180 gene loci involved in TPO indications alone, some for hypoT, some for hyperT. You may well have inherited a dominant form, since that is more common in women, but both types and combinations have been found. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 28, 2007 Report Share Posted April 28, 2007 oh puhlease iodine deficiency is not genetic. Gracia & Gail on wrote: > > > I don't think so. One disease, Hoshimotos, one mode of inheritance. It > doesn't make sense to me that it could be polygenic, as that would show > up as varying degrees of hypoT--like hip dysplasia in dogs. They have identified over 180 gene loci involved in TPO indications alone, some for hypoT, some for hyperT. You may well have inherited a dominant form, since that is more common in women, but both types and combinations have been found. Chuck ------------------------------------------------------------------------------ No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.467 / Virus Database: 269.6.1/777 - Release Date: 4/26/2007 3:23 PM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 29, 2007 Report Share Posted April 29, 2007 Gracia, You wrote: > > > oh puhlease > iodine deficiency is not genetic. The rather well documented genetic component refers to predisposition. Environment also plays a part. Iodine deficiency one of many possible environmental factors, but the fact remains that most people do NOT get goiter or thyroid related conditions, even with iodine deficient diets. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 29, 2007 Report Share Posted April 29, 2007 That is fascinating! Is the study online, as I would really like to read it. And what are the types? There's autoimmune thyroiditis, called Hashimoto's, but there is obviously another type? Or are you telling me there is more than one type of AIT? Gail > They have identified over 180 gene loci involved in TPO indications > alone, some for hypoT, some for hyperT. You may well have inherited a > dominant form, since that is more common in women, but both types and > combinations have been found. > > Chuck > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 29, 2007 Report Share Posted April 29, 2007 & Gail on wrote: > > > That is fascinating! Is the study online, as I would really like to > read it. And what are the types? It was a review of many other studies. As I recall, I was looking for a completely different condition and ran across it. Here some older ones that come close, although none of them give the grand total. http://jcem.endojournals.org/cgi/reprint/87/12/5385.pdf http://jcem.endojournals.org/cgi/content/full/87/12/5385 http://www.journals.uchicago.edu/cgi-bin/resolve?id=doi:10.1086/378588 & erFrom=-2\ 108051513054172025Guest http://jcem.endojournals.org/cgi/content/abstract/83/5/1580 http://edrv.endojournals.org/cgi/content/full/24/5/694 http://hmg.oxfordjournals.org/cgi/content/abstract/10/13/1379 Hashimoto's thyroiditis is really more of a syndrome with many possible causes, many types of immune responses that attack the thyroid. Autoimmune thyroiditis is a synonym for Hashimoto's. It is also sometimes called Hashimoto's Struma. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 30, 2007 Report Share Posted April 30, 2007 Thanks Chuck. I can't read this now because my computer is unwell, and froze when I tried to get to it. Speaking of Hashi's and hereditary, I have spoken with Dr. Lowe, who believes I must have a genetic mutation, which can be tested for. Unfortunately it's a very expensive DNA test that doesn't have a lab anywhere near us. Anyway, it seems I am unique. There are two other women who have been written up as having to take 500 mcg Cytomel to get better. Nobody has ever taken 775 mcg and felt nothing. So I have a very bad case of thyroid resistence. Gail > It was a review of many other studies. As I recall, I was looking for a > completely different condition and ran across it. Here some older ones > that come close, although none of them give the grand total. > > http://jcem.endojournals.org/cgi/reprint/87/12/5385.pdf > http://jcem.endojournals.org/cgi/content/full/87/12/5385 > http://www.journals.uchicago.edu/cgi-bin/resolve? id=doi:10.1086/378588 & erFrom=-2108051513054172025Guest > http://jcem.endojournals.org/cgi/content/abstract/83/5/1580 > http://edrv.endojournals.org/cgi/content/full/24/5/694 > http://hmg.oxfordjournals.org/cgi/content/abstract/10/13/1379 > > Hashimoto's thyroiditis is really more of a syndrome with many possible > causes, many types of immune responses that attack the thyroid. > Autoimmune thyroiditis is a synonym for Hashimoto's. It is also > sometimes called Hashimoto's Struma. > > Chuck > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 1, 2007 Report Share Posted May 1, 2007 Gail, You do seem to have an unusually severe and resistant case. I do recall one paper that said that the dominant genotypes seem to " favor " females, while the recessive and/or partial penetrance seems to " favor " men. Chuck You wrote: > > > Thanks Chuck. I can't read this now because my computer is unwell, > and froze when I tried to get to it. > Speaking of Hashi's and hereditary, I have spoken with Dr. Lowe, who > believes I must have a genetic mutation, which can be tested for. > Unfortunately it's a very expensive DNA test that doesn't have a lab > anywhere near us. Anyway, it seems I am unique. There are two other > women who have been written up as having to take 500 mcg Cytomel to > get better. Nobody has ever taken 775 mcg and felt nothing. So I have > a very bad case of thyroid resistence. > Gail > > > It was a review of many other studies. As I recall, I was looking > for a > > completely different condition and ran across it. Here some older > ones > > that come close, although none of them give the grand total. > > > > http://jcem.endojournals.org/cgi/reprint/87/12/5385.pdf > <http://jcem.endojournals.org/cgi/reprint/87/12/5385.pdf> > > http://jcem.endojournals.org/cgi/content/full/87/12/5385 > <http://jcem.endojournals.org/cgi/content/full/87/12/5385> > > http://www.journals.uchicago.edu/cgi-bin/resolve? > <http://www.journals.uchicago.edu/cgi-bin/resolve?> > id=doi:10.1086/378588 & erFrom=-2108051513054172025Guest > > http://jcem.endojournals.org/cgi/content/abstract/83/5/1580 > <http://jcem.endojournals.org/cgi/content/abstract/83/5/1580> > > http://edrv.endojournals.org/cgi/content/full/24/5/694 > <http://edrv.endojournals.org/cgi/content/full/24/5/694> > > http://hmg.oxfordjournals.org/cgi/content/abstract/10/13/1379 > <http://hmg.oxfordjournals.org/cgi/content/abstract/10/13/1379> > > > > Hashimoto's thyroiditis is really more of a syndrome with many > possible > > causes, many types of immune responses that attack the thyroid. > > Autoimmune thyroiditis is a synonym for Hashimoto's. It is also > > sometimes called Hashimoto's Struma. > > > > Chuck > > > > > > > ------------------------------------------------------------------------ > > No virus found in this incoming message. > Checked by AVG Free Edition. > Version: 7.5.467 / Virus Database: 269.6.2/781 - Release Date: 4/30/2007 9:14 AM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 1, 2007 Report Share Posted May 1, 2007 IMO you have a very bad case of iodine deficiency http://www.helpmythyroid.com Gracia Thanks Chuck. I can't read this now because my computer is unwell, and froze when I tried to get to it. Speaking of Hashi's and hereditary, I have spoken with Dr. Lowe, who believes I must have a genetic mutation, which can be tested for. Unfortunately it's a very expensive DNA test that doesn't have a lab anywhere near us. Anyway, it seems I am unique. There are two other women who have been written up as having to take 500 mcg Cytomel to get better. Nobody has ever taken 775 mcg and felt nothing. So I have a very bad case of thyroid resistence. Gail > It was a review of many other studies. As I recall, I was looking for a > completely different condition and ran across it. Here some older ones > that come close, although none of them give the grand total. > > http://jcem.endojournals.org/cgi/reprint/87/12/5385.pdf > http://jcem.endojournals.org/cgi/content/full/87/12/5385 > http://www.journals.uchicago.edu/cgi-bin/resolve? id=doi:10.1086/378588 & erFrom=-2108051513054172025Guest > http://jcem.endojournals.org/cgi/content/abstract/83/5/1580 > http://edrv.endojournals.org/cgi/content/full/24/5/694 > http://hmg.oxfordjournals.org/cgi/content/abstract/10/13/1379 > > Hashimoto's thyroiditis is really more of a syndrome with many possible > causes, many types of immune responses that attack the thyroid. > Autoimmune thyroiditis is a synonym for Hashimoto's. It is also > sometimes called Hashimoto's Struma. > > Chuck > ------------------------------------------------------------------------------ No virus found in this incoming message. Checked by AVG Free Edition. Version: 7.5.467 / Virus Database: 269.6.2/781 - Release Date: 4/30/2007 9:14 AM Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 2, 2007 Report Share Posted May 2, 2007 More than two years ago, you did convince me that I needed adrenal support, and you were right, I did. It made sense to me. But iodine deficiency doesn't make sense to me. I just don't have any reason to think I'm iodine deficient. But I really appreciate your wanting to help people by suggesting this. Gail > > > IMO you have a very bad case of iodine deficiency > http://www.helpmythyroid.com Gracia > > Thanks Chuck. I can't read this now because my computer is unwell, > and froze when I tried to get to it. > Speaking of Hashi's and hereditary, I have spoken with Dr. Lowe, who > believes I must have a genetic mutation, which can be tested for. > Unfortunately it's a very expensive DNA test that doesn't have a lab > anywhere near us. Anyway, it seems I am unique. There are two other > women who have been written up as having to take 500 mcg Cytomel to > get better. Nobody has ever taken 775 mcg and felt nothing. So I have > a very bad case of thyroid resistence. > Gail > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 2, 2007 Report Share Posted May 2, 2007 you might want to do the test available from http://www.helpmythyroid.com !!! you would find it interesting I think. Gracia More than two years ago, you did convince me that I needed adrenal support, and you were right, I did. It made sense to me. But iodine deficiency doesn't make sense to me. I just don't have any reason to think I'm iodine deficient. But I really appreciate your wanting to help people by suggesting this. Gail Recent Activity a.. 26New Members Visit Your Group Quote Link to comment Share on other sites More sharing options...
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