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Blood Labs. Mitochondrial & CAIH, PSC, and PBC.......

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<A HREF= " http://pbcers.org/HTML/pbclabs.htm " >Click here: Blood Labs of

Interest to PBCers</A> Mitochondrial Abs are positive, usually in high titers

in > 95% of patients with PBC. These heterogeneous Abs are also present in

30% of patients with " autoimmune " chronic active hepatitis (HBsAg negative)

and in some cases of connective tissue disease. They are absent in mechanical

obstruction of the biliary system and primary sclerosing cholangitis; hence

they have important diagnostic value, particularly when liver histopathology

is equivocal.

Other Abs occur in autoimmune chronic active hepatitis: Smooth muscle Ab

(SMAb) particularly directed against actin is found in 70% and

double-stranded antinuclear Abs (ANAbs) are positive in high titers. Some

patients exhibit another auto-Ab, antiliver-kidney -microsome Ab (LKM-1 Ab),

which appears to define a subgroup of patients with chronic active hepatitis.

None is diagnostic, and none reveals the pathogenesis of the disease process.

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