Vermox

[Guest guest]

For those of you intrested in taking the quick chemical prescription

route for parasites from what I read Vermox seems to be the drug of

choice. Seems to kill hook, thread, pin, whip & tape worm if taken

in the correct dosages.

It would be interesting to hear what else you may come up with. Here

in the States I have always gone the herbal route once a year. Don't

honestly know if I am killing anything that way or not.

Vache

(not a doctor & not supplying medical advise)

http://www.drugbase.co.za/data/pi/jverm100.htm

Proprietary name (and dosage form)

VERMOX* 100 mg tablets

Composition

One tablet contains 100 mg of the active substance, mebendazole.

Pharmacological classification

A.12 Anthelmintics, Bilharzia medicines, Filaricides, etc.

Pharmacological action

Mebendazole is a broad-spectrum anthelmintic. It appears to affect

the cytoplasmic microtubules of the tegumental or intestinal cells of

parasitic worms resulting in a transport blocking of secretory

vesicles. This may lead to impaired coating of the membranes followed

by a decreased digestion and absorption of nutrients, eg. glucose,

thereby depleting the energy level until it is inadequate for

survival.

Indications

VERMOX* is indicated for the treatment of single and mixed helminth

infestations caused by:

nematodes such as:

Trichuris trichiura (whipworm)

Ancylostoma duodenale (hookworm)

Necator americanus (hookworm)

Ascaris lumbricoides (large roundworm)

Ternidens deminutus

Enterobius vermicularis (pinworm)

Strongyloides stercoralis (threadworm)

cestodes such as:

Taenia spp (tapeworm)

infestations by Moniliformis moniliformis

Contra-indications

In persons who have shown sensitivity to mebendazole.

VERMOX* should not be given during pregnancy.

* Trademark.

1162y

Dosage and directions for use

Whipworm; Hookworm; Large Roundworm; Pinworm; Ternidens deminutus;

Infestations by Moniliformis moniliformis: One tablet (100 mg) twice

daily (morning and evening) for three consecutive days. This standard

dosage applies to adults, children and infants.

Tapeworm (Taenia spp): One tablet (100 mg) twice daily (morning and

evening) for six consecutive days. This standard dosage applies to

adults, children and infants.

Threadworm (Strongyloides stercoralis):

Adults: Two tablets (200 mg) twice daily (morning and evening) for

three consecutive days.

Children: One tablet (100 mg) twice daily (morning and evening) for

three consecutive days.

VERMOX* is easily accepted even by children but may be crushed and

given with some liquid.

A second course of treatment should be given to those patients who

are still infected three to four weeks after the first course.

In worm-eradication campaigns the standard course should be

administered every quarter during the first year.

If a helminth is not susceptible to the standard dosage, a treatment

course of longer than three days and/or involving higher doses than

100 mg for tablets is recommended.

The efficacy of VERMOX* is dependent upon the duration of physical

contact between drug and parasite. When gastro-intestinal transit

time is accelerated eg. in diarrhoea it is necessary to repeat the

dose at more frequent intervals daily.

For infants under 2 years, see " Side-Effects and Special Precautions " .

Side-effects and special precautions

In doses exceedings the recommended dosage, VERMOX* can cause

vomiting, fever, transient neutropenia, alopecia, bone marrow

suppression, raised hepatic enzymes, hepatitis and glomerular

nephritis. Agranulocytosis can occur.

In cases of massive infestation expulsion of worms may occasionally

cause transient symptoms such as abdominal pain and diarrhoea.

Adverse reactions

Hypersensitivity reactions such as exanthema, rash, urticaria and

angio-oedema have been observed.

Precautions

Usage in children below 2 years is not well documented and as there

have been very rare reports of convulsions in this age group, VERMOX*

should only be given to very young children if their worm infections

interferes significantly with the nutritional status and the physical

development.

1162y

Drug interactions

Concomitant treatment with cimetidine may inhibit the metabolism of

the mebendazole in the liver, resulting in increased plasma

concentrations of the drug especially during prolonged treatment. In

the latter case, determination of plasma concentrations is

recommended in order to allow dose adjustments.

Known symptoms of overdosage and particulars of its treatment

In the event of accidental overdosage, abdominal cramps, nausea,

vomiting and diarrhoea may occur. If poisoning or excessive

overdosage is suspected it is recommended, on general principles,

that vomiting be induced or gastric lavage be performed, and such

symptomatic supportive therapy be administered as appears indicated.

Activated charcoal may be given.

Identification

A faintly pink, bevel edged, scored tablet with " Janssen " on one side

and " Me " on the other side.

100

Presentation

Carton containing one or more blister packs of 6 tablets.

Storage instructions

Store below 25 oC.

Keep out of reach of children.

Registration number

G/12/105

Name and business address of the applicant

JANSSEN PHARMACEUTICA (PTY) LTD

(Reg. No. 80/11122/07)

15th Road

HALFWAY HOUSE

1685

Date of publication of this package insert

24 January 1992