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Margo

You have given me hope!! 14 years!!

Even though the research I have found has said the survival rate with

out meds is 10 years, and with meds u can live a sortive normal long

live??

I have never heard that 10year mark for meds??

it's hard not to get depressed with this " unknown crap " I'm having my

second biopsy in november (to see how long , it is before we need to

talk to transplant people ) quote from my doctor.

Since that visit I have been so worried, and no one gets it, the pass

it off as me being negative??

I'm not I'm just scarred and that is aloud

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Hi

I have a friend in denmark, and his daughter is 7/8 I believe and she

has aih. He I believe does not belong to this group. the mail is too

much for him.

If you want to contact him, I emial him and see if it is all right

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Geri I am sorry to hear you are having so much trouble. I too have had

normal labs for several months now I am down to 2.5 mg of pred. and 100

immuran I just saw my Dr. and asked if my labs are normal why do I feel

worse than I did in a long time My body hurts like crazy I feel dizzy

which I had not been dizzy for a long time and I am soo tired almost all

the time.Her answer was due to coming off Pred. We have reduced it very

slowly 2.5 mg every 6 weeks. I don't get how if you are doing better why

do we feel so badly.

Pa.

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  • 1 year later...

> I have been doing some research on autoimmune hepatitis and discovered the

pains i suffer are called arthralgia pains.My fingers,knees, shoulder, etc. You

can look it up thru search. It looks like there is not much I can do to try and

avoid them. check it out. Any feedback would be appreciated.

>

> Bobbie

Hello bobbie

I have had AIH for almost 5years now...... I can not believe it's been that

long...

I expreienced a great deal of pain in my 2nd and thrid and some into my fourth

year with this and then guess what.. I was having chest pains and they could not

figure out what it was.. and then a conclusion was an inflamation of the chest

wall... they (doctors) recommended to try Vioxx as a prn.. so I did and it did

not just cure the chest pain, it cured all pain.... I have no more joint pain...

unless i do not take it.. I usually take it on days that I know I have to go go

go. I have not experienced these pains in my chest for a long while now... but

the vioxx has not only taken away my joint pain everywhere but also has helped

in the migrane department which I was getting everyday!!! it also makes me

peppy!!!LOL

So I have told my doctor I like to stay on it, and it's ok... it has not

affected my liver so far... and minmal chance.. etc.. just keeping an eye on

it...

But i feel good, so that's what mattters to me.

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  • 5 weeks later...

Thanks Ginger!! :) This might answer s question. How are you

doing?

Love and serenity

Jerry

Source: Current Medical Diagnosis & Treatment 39th Edition, 2000

McGraw Hill Publishers ( ISBN 08385 15916)

Edited by: Lawrence M. Tierney, Jr, Stehen J. McPhee,

Maxine A. Papadakis

AutoImmune Hepatitis

This is generally a disease of young women but can occur in either sex at any

age.

Affected persons are often positive for HLA-B8 and -DR3 or, in older patients,

HLA-DR4. The onset is usually insidious, but about 25% of cases present as

an acute attack of hepatitis and some cases follow a viral illness such as

Hepatitis A,

Epstein-Barr infection, or measles or exposure to a drug or toxin such as

nitrofurantoin. The serum bilirubin is usually increased but 20% of patients

are anicteric. In classic cases, examination reveals a healthy-appearing

young woman with multiple spider nevi, cutaneous striae, acne, hirsutism and

hepatomegaly. Amenorhea may be a presenting feature. Extrahepatic features

include arthritis,

Sjogren's Snydrome, thyroiditis, nephritis, ulcerative colitis, and

Coombs-positive

hemolytic anemia.

In classic (type 1) autoimmune hepatitis, antinuclear antibody (ANA) or

smooth muscle antibody (either or both) is detected in serum. Serum gamma

globulin levels are typically elevated (up to 5-6 g/dL). In patients with

high gamma globulin levels, the enzyme immunoassay for antibody to HCV may be

falsely positive. A

second (type 2) rarely seen in the United States but more common in Europe,

is characterized by circulating antibody to liver-kidney microsomes

(anti-LKM1)

without anti-smooth muscle antibody or ANA. Concurrent primary biliary

cirrhosis or primary sclerosing cholangitis has been recognized in up to 13%

of patients with autoimmune hepatitis.

Prednisone with or without azathioprine has been shown to improve symptoms,

decrease the serum bilirubin, aminotransferase and gamma globulin levels, and

reduce hepatic inflammation. Symptomatic patients with serum

aminotransferase levels elevated tenfold (or fivefold if the serum globulins

are elevated at least twofold)

are optimal for therapy, and patients with more modest enzyme elevations may

be considered for therapy depending on the clinical circumstances.

Prednisone or an equivalent drug is given initially in doses of 30 mg orally

daily with azathioprine or mercaptopurine, 50 mg/d orally, which are

generally well tolerated and permit the use of lower corticosteroid doses.

Nevertheless, complete blood counts should be monitored monthly thereafter

because of the small risk of bone marrow suppression. The dose of prednisone

is lowered from 30 mg/d after 1 week

to 20 mg/d and again after 2 to 3 weeks to 15 mg/d. Ultimately, a

maintenance dose of 10 mg/d is achieved. While symptomatic improvement is

often prompt biochemical improvement is more gradual, with normalization of

serum aminotransferase levels after 6-12 months in may cases. Histologic

resolution of

inflammation may take up to 18-24 months, the time at which repeat liver

biopsy is recommended. Failure of aminotransferase levels to normalize

invariable predicts lack of histologic resolution.

The response rate to therapy with prednisone and azathioprine is 80-90%.

Cirhosis however does not reverse with therapy and may even develop after

apparent biochemical and histologic remission (absence of inflammation).

Once remission is achieved, therapy may be withdrawn, but the subsequent

relapse rate is 50-90%.

Relapses may again be treated in the same manner as the initial episode, with

an expected remission rate again of 80-90%. After successful treatment of a

relapse the patient may be kept indefinately on azathioprine up to 2 mg/kg

and the lowest dose of prednisone needed to maintain aminotransferase levels

as close to normal as possible. Nonresponders to prednisone and azathioprine

may be considered for a trial of cyclosporine or methotrexate. Liver

transplantation may be required for treatment failures, and the disease has

been recognized to recur in some transplanted livers as immunosuppression is

reduced.

Ginger-gehud119@...

MAY YOUR DAY BE BLESSED WITH JOY

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  • 2 months later...
Guest guest

Hi Judy,

I was dx when I was 14 (1995) and had a transplant on

the 6th July 1999. I had a few complications but

nothing the doc's couldn't handle. I was in hospital

for only two weeks. But the next year, in March 2000

the AIH came back. This is because transplantation

does not cure the basic genetic defects relating to

control of the autoimmune reaction. But the good thing

is I feel a lot better and I can do more and I'm not

in hospital as much as I used to be :). I still get

tired and that, but thats to be expected.

I'm sure you will be fine

All the best

Matt Hastings

==================================================

--- judynor@... wrote:

> I was diagnosed with AIH 3 yrs. ago. I have been on

> 6mp and aldactone

> since that time. In nov. I flared and was placed on

> Prednizone 15mg.

> I was referred to UAB to be evaluated for the

> transplant list and was

> listed. I really didnt expect to even be placed on

> the list. I would

> like to know if anyone at this site has had a liver

> transplant and if

> so how you are doing? My symptoms are FATIGUE,wt.

> gain, yellow eyes,

> hemangiomas of the skin, slight edema that

> fluctuates. I have good

> days and bad days,but I am still working full time.

> I just need to

> hear from someone going through the same thing.

>

>

> Judy

>

>

__________________________________________________

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Guest guest

But the next year, in March 2000

the AIH came back.

Dear Matt,

I have a question for you -- did you continue to take prednisone post transplant? And what testing did your tx team do to determine the AIH is back? I know that transplantation does not cure AIH and that you will always have it. But I understood that prednisone treatment helps keep it in "check".

Thanks,

Cheryl & Randy

Randy tx 12-14-99 AIH

Cheryl is his living liver donor

Cleveland Clinic Foundation, OH

Living Liver Donor Surgery #2

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In a message dated 4/28/2001 6:58:28 PM Central Daylight Time,

judynor@... writes:

<< Has anyone else had problems with vision? >>

Actually, right before I was diagnosed and in the throes of acute attack, I

had problems where my vision would literally black out for 5 minutes at a

time. It was really weird. I could funtion in every other way, but I just

couldn't see anything at all. It was one of the things (as well as many

others) that finally forced me to see a doctor.

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Guest guest

Hi,

This is Judy from Pensacola,Fl. I've been reading everyiones

messages,but havent had time to email. I saw that Jodie's fund was

based in Haines,Fl. I was wondering where this is located and where

will the transplant be done? I'm on the panhandle and have been seen

at UAB in Birmingham. Great doctors. It's amazing to me that I had

never heard of AIH until my diagnosis and yet there are alot of us

out there and probably a lot more that we dont know. I have a lot of

joint pain and swelling right below my knees. Pain in my hands,too. I

had an episode in Dec. where I lost the vision in the top half of my

right eye for 5 min. Many test later they think it was a TIA not a

migraine which I do get. Has anyone else had problems with vision?

Judy/Pensacola

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  • 2 weeks later...
Guest guest

My Dr. told me it was hereditary. My grandmother had

cirrhosis and died at 89,never drank. I'll take 89 any

day. Noone else has had this in my family,but I worry

about my girls.

Judy/pensacola

--- nanacherry@... wrote:

> Can someone tell me if AIH is hereditary? I thought

> I read somewhere that it came from a predestined

> gene. (If I know what I remembered).

> thanks cherry

>

__________________________________________________

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  • 4 months later...

Hi Gloria,isn't it interesting that many people have the same exxperience in

the diagnosis stage,i was diagnosed seven years ago,i was put in

isolation,my family were too,i was a horrible experience,and its still

happenning.people,in particularly the people who ar ethere to care for us

when we're in such situations need to be educated

>From: gloriagauss@...

>Reply-

>

>Subject: [ ] AIH

>Date: Wed, 10 Oct 2001 08:54:09 EDT

>

>Hello! Patty,

> I do not have cirrohsis, but peri-portal fibrosis in my liver caused

>from a

>severe flare up, I first found out that I had AIH in April of 2000, I was

>like your symtoms you described, and in the hospital,not knowing what I

>had,

>in isolation, and the nurses were afraid to come in around me. I almost

>died!

>I suffer I think from just about every side effect of prednisone, and my

>blood pressure is a real problem from it, I take three different pills for

>it

>as of yesterday, one more was added!

> Hope to hear from you soon,gloriagauss@...

_________________________________________________________________

Get your FREE download of MSN Explorer at http://explorer.msn.com/intl.asp

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HI Gloriagauss, Im not familiar with per-portal fibrosis. I need to

look it up. I havent had problems with high blood pressure but in

Dec 2000 I had a migraine for 3 weeks! After MRI, Catscan Eye doctor

my specialist in Anchorage said " oh thats probabally a side effect

from the prednisone. " arghhhhhhhh!!!! Thats when I burst in to tears

and begged to start the process of coming off prednisone. It has

taken me since then to come off of it. Slowly!!!!!!! Anyway, thanks

for the ear!

Peady

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it makes me mad to that my clothes are tight in the waist,I guess its because the meds, cause the fat to settle there, my face was so bloated last Dec. I was ashamed to even look in the mirror, coming down on the pred. since than has helped that, it is still round, but not swollen anymore, and I finally have a neck again. It is so hard to look in the mirror and see the physical changes our bodies have gone through, But I keep telling myself keep the faith it will get better, but it is just not quite as quick as I want, and I can only pray that my liver keeps responding! Do you know if you can get cirrohsis if if our enzymes are o.k.? I wonder about that! gloriagauss@...

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In a message dated 10/12/01 4:52:44 PM Pacific Daylight Time, gloriagauss@... writes:

I was ashamed to even look in the mirror,

Hey, we're alive and doing what it takes to get better. It is hard, as a woman, to not feel ashamed of those physical changes, but they are signs that we are on the track to a longer, better life. (My face became so swollen that I literally, physically couldn't smile, and I could open my mouth only a little way.)

Harper (AIH 5/00)

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> it makes me mad to that my clothes are tight in the waist,I

guess its

> because the meds, cause the fat to settle there, my face was so

bloated last

> Dec. I was ashamed to even look in the mirror, coming down on the

pred.

> since than has helped that, it is still round, but not swollen

anymore, and I

> finally have a neck again. It is so hard to look in the mirror and

see the

> physical changes our bodies have gone through, But I keep telling

myself keep

> the faith it will get better, but it is just not quite as quick as

I want,

> and I can only pray that my liver keeps responding! Do you know if

you can

> get cirrohsis if if our enzymes are o.k.? I wonder about that!

> gloriagauss@a...

Sorry--I do not know. One source seems to say yes and another no. I

don't think anyone really knows. I already have cirrhosis, I had it

when I was diagnosed almost three years ago. As far as I know, it's

not worse--but I've only had one biopsy and am not anxious to have

another. Glad things are improving for you on the pred--right now,

I'm off pred and just on azath. However, there's no guarantee that I

can stay off it--I take this good fortune month by month and hope for

the best. I've sort of become kind of accepting of this(I'm not sure

if that's just the right word). My attitude(now) is " do what I can

and accept what ever is ahead " . It took me a while to get to this

frame of mind I'll admit. Jean

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