Re: more info to look at

July 3, 2004

Looks like liver/kidney involvement is a cause of absorption problems

of t3---

hmmm---

I would look into milk thistle for sure---and I do have my daughter

on this one

https://www.immunesupport.com/shop/product.cfm?Product__Code=PH185

She is reading this amazing book that she told me about last night---

have to get the name--but very into why we have absorption problems---

·Supports effective liver detoxification with methionine and milk

thistle

·Comprehensive formula includes schisandra, the liver-protective herb

·Stimulates improved liver cell function with defatted liver

concentrate

It's hard to overstate the importance of the liver to general

health. The second largest organ in the body after the skin, it

processes all nutrients, toxins, and any other substances entering

the body through the intestines, lungs, or skin.

LiverRight™ is a comprehensive hormone-free formula that is packed

with these powerful detoxifiers, antioxidants and liver health

supporters:

2 capsules of LiverRight™ contain: --350mg l-Methionine for heavy

metal removal and healthy homocysteine levels --250mg Schisandra for

its lignans with liver-protective action --250mg Defatted Liver

Concentrate (hormone free) to stimulate improved liver cell function -

-200mg Betaine (trimethylglycine) for methyl groups needed for proper

liver function --200mg Green Tea (50% extract) for antioxidant

protection --200mg Turmeric (95% extract) for a healthy inflammatory

response --100mg Artichoke (5% extract) for healthy circulation and

liver support --100mg Milk Thistle (80% extract) with silymarin for

liver detoxification and antioxidant protection.

Methionine for Detoxification

Methionine promotes the body's natural detoxification processes and

specifically supports mercury removal. Methionine helps suppress and

neutralize toxic chemical activity, and functions as a chelator, a

binding agent that deactivates and removes toxic metallic substances

by altering their molecular structure. This process inhibits

transport of mercury throughout the body, including the brain and

central nervous system.

> Endocrine Index Glossary

>

> Chemistry of Thyroid Hormones

>

http://arbl.cvmbs.colostate.edu/hbooks/pathphys/endocrine/thyroid/chem

> .html

> --------------------------------------------------------------------

--

> ----------

>

> Thyroid hormones are derivatives of the the amino acid tyrosine

bound

> covalently to iodine. The two principal thyroid hormones are:

>

> thyroxine (known affectionately as T4 or L-3,5,3',5'-

> tetraiodothyronine)

> triiodotyronine (T3 or L-3,5,3'-triiodothyronine).

> As shown in the following diagram, the thyroid hormones are

basically

> two tyrosines linked together with the critical addition of iodine

at

> three or four positions on the aromatic rings. The number and

> position of the iodines is important. Several other iodinated

> molecules are generated that have little or no biological activity;

> so called " reverse T3 " (3,3',5'-T3) is such an example.

>

> A large majority of the thyroid hormone secreted from the thyroid

> gland is T4, but T3 is the considerably more active hormone.

Although

> some T3 is also secreted, the bulk of the T3 is derived by

> deiodination of T4 in peripheral tissues, especially liver and

> kidney. Deiodination of T4 also yields reverse T3, a molecule with

no

> known metabolic activity.

>

> Thyroid hormones are poorly soluble in water, and more than 99% of

> the T3 and T4 circulating in blood is bound to carrier proteins.

The

> principle carrier of thyroid hormones is thyroxine-binding

globulin,

> a glycoprotein synthesized in the liver. Two other carriers of

import

> are transthyrein and albumin. r proteins allow maintenance of

a

> stable pool of thyroid hormones from which the active, free

hormones

> are released for uptake by target cells.

>

> --------------------------------------------------------------------

--

> ----------

July 3, 2004

Can SSRI's like Zoloft taken for years produce hypothyroidism requiring thyroid

supplementation? I read that SSRI's activate enymes in the liver that metabolize

thyroid hormone, thus increasing the requirement. In people who are " normal "

this presents no problem. However, in, people with a diseased thyroid, it may

produce hypothyroidism or even make it worse, and the same in people who take

their hormone from a bottle. If you stop taking the SSRI you need to take

thyroid hormone supplementation. I stopped taking Zoloft in 1998 after being on

it for 4 years and never experienced feeling so cold as I did since then.

Wondering if a toxic backed up liver that is overstressed and congested can

cause all the lethargy and coldness, just burned out, dragged out, drained

energy rather than the thyroid itself. My liver enzymes are high as well as

blood fats. I always feel easily stressed, worried, low emotional and physical

stamina, lots of nervous energy leading to nervous exhaustion, anxiousness,

burned out very easily just from any stress or poor sleep, more energy at night

thus getting to bed late makes the low energy worse, hair fallout, G.I.

distress, etc. Before I was always so anxious with panic attacks that I couldn't

sleep. Now I want to sleep all the time even during the day because I am so

exhausted and dragged out and cold. Yet my core temperature was normal at 98.6

this afternoon. Just a mild drop in temperature in the weather makes me worse

too.

Chris