Re: Organic Acid Profile

[Guest guest]

Holly: it sounds like your doing everything that you can for a child of 4, I

have 2 grandchildren with autism & have been trying to get my daughter to do

something but she is under to much stress to even try. i applaude you! its

got to be a hard job! i wrote a book about my grandson when he was 5 (now 7)

and self published it this past spring, if you want to take a look at it go

to www.mogdrmombooks you can see me and him. this was a true story he

asked me one day.

Possibly your son could be going thru die-offs, how is his bowels? thats

the key to this whole thing, keep them going daily, you can rub castor oil on

his lower stomach, massage it in & that will help him to go since he can't

take fiber pills. Keep us informed but it sounds like your doing good. Mog

[Guest guest]

Dear Mog:

Thanks so much for your note. I can't wait to read your book. I can't

imagine what it would be like to have 2 autistic children; I know how

stressed out I am with one. Thank god your daughter has you to help. My son

moves his bowels every other day and they are mushy. He is not potty

trained; I think the sensation comes too quickly for him to react. I'll look

into the castor oil. Thanks for the tip.

Best to you and your family. Happy Thanksgiving

Holly

[Guest guest]

Ruth< www.mogdrmombooks.com

I think you left off the .com part. Mog

[Guest guest]

Hi, Helen - I think your and my amino acid results were remarkably similar.

Have you talked to Dr. Cheney about it? He said mine was pretty good - just a

few problems, one of which possibly indicated low GSH (low oxo glutaric????) . I

think he'll be pleased with your report.

He also had me do the Detox test - as I remember I had one indication of low

GSH but I passed the detoxification part - where you metabolize something -

fine; he never put whey in my protocol.

Yours truly, Cort

helen9jora <helenjora@...> wrote:

The Great Plains Laboratory just sent me a copy of my 24 hour urine

test results.

Comments from anyone, esp. Rich, welcome. Reference range is in

parens.

From what they said in the comments section, glutathione

depletion/deficiency is what is going on. Also low on vitamin C, that

I can take. I have been on Immune Pro and Goatien for some time, and

did three bottles of Liposomal GSH, took a break, am doing some more

now. Doesn't seem to do me much good. The high kynurenic acid is a

tryptophan metabolite and I take tryptophan at night, so that

probably explains that.

Helen

Organic Acid Profile

Great Plains Laboratory

Yeast/Fungal

Citramalic 0.31 (0.0 –2.0)

5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

3-oxoglutaric 0.0 (0.0 –0.5)

furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

furancarbonlglycine 0.52 (0.0 – 60.0)

tartaric 0.35 (0.0 – 16.0)

arabinose 45.21 (0.0 – 47.0)

Bacterial

2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

VMA analog 0.39 (0.0 – 31.0)

Glycolysis

Lactic 1.39 (0.0 – 100.00)

Pyruvic 0.91 (0.0 – 50.0)

2-hydroxybutyric 1.22 (0.0 – 2.0)

glyceric 0.67 (0.0 – 10.0)

Krebs Cycle

Succinic 2.02 (0.0 – 20.0)

Fumaric 0.10 (0.0 – 10.0)

2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

aconitic 6.12 (0.0 – 25.0)

citric 810.56 (180.0- 560.0) HIGH

Amino Acid Metabolites

2-hydroxyisovaleric 0.00 (0.0 – 2.0)

2-oxoisovaleric 0.00 (0.0 – 2.0)

3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

hydroxyisocaproic 0.14 (0.0 – 2.0)

2-oxoisocaproic 0.10 (0.0 – 2.0)

2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

mandelic 0.00 (0.0 – 5.0)

phenyllactic 0.16 (0.0 – 2.0)

phenylpyruvic 2.38 (0.0 – 5.0)

homogentisic 0.18 (0.0 – 2.0)

4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

3-indoleacetic 0.79 (0.0 – 10.0)

Neurotransmitters

HVA 0.89 (0.0 – 3.5)

VMA 2.92 (0.0 – 3.5)

5-hydroxyindoleacetic 1.26 (0.0 –20.0)

Pyrimidines

Uracil 2.24 (0.0 – 22.0)

Thymine 0.35 (0.0 – 2.0)

Fatty Acid Metabolites

3-hydroxybutyric 0.69 (0.0 – 10.0)

acetoacetic 0.89 (0.0 – 10.0)

ethylmalonic 1.36 (0.0 – 10.0)

methylsuccinic 0.58 (0.0 – 5.0)

adipic 0.39 (0.0 – 12.0)

suberic 1.77 (0.0 – 2.0)

sebacic 0.09 (0.0 – 2.0)

Toxic Indicators

Pyroglutamic 4.86 (20.0 – 115.0) LOW

Orotic 0.22 (0.0 – 3.5)

Hydroxyhippuric 0.76 (0.0 – 20.0)

Vitamin Indicators

Methylmalonic 0.82 (0.0 – 5.0)

Ascorbic 4.61 (10.0 – 200.0)

Kynurenic 4.91 (0.0 – 2.0) HIGH

Methylcitric 0.17 (0.0 – 12.0)

Pyridoxic 2.34 (2.0 – 26.0)

Pantothenic 7.03 (1.0 – 4.0) HIGH

Miscellaneous

Glutaric 0.22 (0.0- 2.0)

N-acetyl aspartic 0.00 (0.0 – 100.0)

3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

glycolic 0.74 (0.0 – 100.0)

oxalic 44.91 (0.0 – 100.)

malonic 0.57 (0.0 – 10.0)

methylglutaric 0.32 (0.0 – 10.0)

hippuric 194.57 (10.0 – 400.0)

4-hydroxybutyric 0.77 (0.0 – 5.0)

phenylcarboxylic 0.81 (0.0 – 15.0)

indole-like compound 5.30 (0.0 – 60.0)

This list is intended for patients to share personal experiences with each

other, not to give medical advice. If you are interested in any treatment

discussed here, please consult your doctor.

[Guest guest]

Rich, when I spoke with Fallon a while back he talked about trytophan

turning into kynurenic acid...sometimes its not a methylation defect

but chronic infection. I'm not sure why...and it could be implicated

in the depression accompanying chronic infection/illness.

Also, I think maybe I will just get the organic acids test. The more I

investigate the SNP's the more I feel they are so much in the infancy

of understanding them...wouldn't a comprehensive organic acids test

give me info about my detoxing abilities?

> >

> > The Great Plains Laboratory just sent me a copy of my 24 hour

> urine

> > test results.

> >

> > Comments from anyone, esp. Rich, welcome. Reference range is in

> > parens.

> >

> > From what they said in the comments section, glutathione

> > depletion/deficiency is what is going on. Also low on vitamin C,

> that

> > I can take. I have been on Immune Pro and Goatien for some time,

> and

> > did three bottles of Liposomal GSH, took a break, am doing some

> more

> > now. Doesn't seem to do me much good. The high kynurenic acid is a

> > tryptophan metabolite and I take tryptophan at night, so that

> > probably explains that.

> >

> > Helen

> >

> > Organic Acid Profile

> >

> > Great Plains Laboratory

> >

> > Yeast/Fungal

> >

> > Citramalic 0.31 (0.0 –2.0)

> > 5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

> > 3-oxoglutaric 0.0 (0.0 –0.5)

> > furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

> > furancarbonlglycine 0.52 (0.0 – 60.0)

> > tartaric 0.35 (0.0 – 16.0)

> > arabinose 45.21 (0.0 – 47.0)

> >

> > Bacterial

> >

> > 2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

> > 4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

> > HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

> > VMA analog 0.39 (0.0 – 31.0)

> >

> > Glycolysis

> >

> > Lactic 1.39 (0.0 – 100.00)

> > Pyruvic 0.91 (0.0 – 50.0)

> > 2-hydroxybutyric 1.22 (0.0 – 2.0)

> > glyceric 0.67 (0.0 – 10.0)

> >

> > Krebs Cycle

> >

> > Succinic 2.02 (0.0 – 20.0)

> > Fumaric 0.10 (0.0 – 10.0)

> > 2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

> > aconitic 6.12 (0.0 – 25.0)

> > citric 810.56 (180.0- 560.0) HIGH

> >

> > Amino Acid Metabolites

> >

> > 2-hydroxyisovaleric 0.00 (0.0 – 2.0)

> > 2-oxoisovaleric 0.00 (0.0 – 2.0)

> > 3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

> > hydroxyisocaproic 0.14 (0.0 – 2.0)

> > 2-oxoisocaproic 0.10 (0.0 – 2.0)

> > 2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

> > mandelic 0.00 (0.0 – 5.0)

> > phenyllactic 0.16 (0.0 – 2.0)

> > phenylpyruvic 2.38 (0.0 – 5.0)

> > homogentisic 0.18 (0.0 – 2.0)

> > 4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

> > 3-indoleacetic 0.79 (0.0 – 10.0)

> >

> > Neurotransmitters

> >

> > HVA 0.89 (0.0 – 3.5)

> > VMA 2.92 (0.0 – 3.5)

> > 5-hydroxyindoleacetic 1.26 (0.0 –20.0)

> >

> > Pyrimidines

> >

> > Uracil 2.24 (0.0 – 22.0)

> > Thymine 0.35 (0.0 – 2.0)

> >

> > Fatty Acid Metabolites

> >

> > 3-hydroxybutyric 0.69 (0.0 – 10.0)

> > acetoacetic 0.89 (0.0 – 10.0)

> > ethylmalonic 1.36 (0.0 – 10.0)

> > methylsuccinic 0.58 (0.0 – 5.0)

> > adipic 0.39 (0.0 – 12.0)

> > suberic 1.77 (0.0 – 2.0)

> > sebacic 0.09 (0.0 – 2.0)

> >

> > Toxic Indicators

> >

> > Pyroglutamic 4.86 (20.0 – 115.0) LOW

> > Orotic 0.22 (0.0 – 3.5)

> > Hydroxyhippuric 0.76 (0.0 – 20.0)

> >

> > Vitamin Indicators

> >

> > Methylmalonic 0.82 (0.0 – 5.0)

> > Ascorbic 4.61 (10.0 – 200.0)

> > Kynurenic 4.91 (0.0 – 2.0) HIGH

> > Methylcitric 0.17 (0.0 – 12.0)

> > Pyridoxic 2.34 (2.0 – 26.0)

> > Pantothenic 7.03 (1.0 – 4.0) HIGH

> >

> > Miscellaneous

> >

> > Glutaric 0.22 (0.0- 2.0)

> > N-acetyl aspartic 0.00 (0.0 – 100.0)

> > 3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

> > glycolic 0.74 (0.0 – 100.0)

> > oxalic 44.91 (0.0 – 100.)

> > malonic 0.57 (0.0 – 10.0)

> > methylglutaric 0.32 (0.0 – 10.0)

> > hippuric 194.57 (10.0 – 400.0)

> > 4-hydroxybutyric 0.77 (0.0 – 5.0)

> > phenylcarboxylic 0.81 (0.0 – 15.0)

> > indole-like compound 5.30 (0.0 – 60.0)

> >

>

[Guest guest]

Rich:

Thank you so much for looking at this and commenting on it. I did

forget to type in LOW for that one value. Recently I started taking

P5P. I have also increased my Immune Pro to two scoops, taken with

one scoop of Goatien. It doesn't seem to do anything noticeable. I am

adding vitamin C. If I have a yeast infection, I don't know about it.

Must be in my intestine.

thanks again,

Helen

> >

> > The Great Plains Laboratory just sent me a copy of my 24 hour

> urine

> > test results.

> >

> > Comments from anyone, esp. Rich, welcome. Reference range is in

> > parens.

> >

> > From what they said in the comments section, glutathione

> > depletion/deficiency is what is going on. Also low on vitamin C,

> that

> > I can take. I have been on Immune Pro and Goatien for some time,

> and

> > did three bottles of Liposomal GSH, took a break, am doing some

> more

> > now. Doesn't seem to do me much good. The high kynurenic acid is

a

> > tryptophan metabolite and I take tryptophan at night, so that

> > probably explains that.

> >

> > Helen

> >

> > Organic Acid Profile

> >

> > Great Plains Laboratory

> >

> > Yeast/Fungal

> >

> > Citramalic 0.31 (0.0 –2.0)

> > 5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

> > 3-oxoglutaric 0.0 (0.0 –0.5)

> > furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

> > furancarbonlglycine 0.52 (0.0 – 60.0)

> > tartaric 0.35 (0.0 – 16.0)

> > arabinose 45.21 (0.0 – 47.0)

> >

> > Bacterial

> >

> > 2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

> > 4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

> > HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

> > VMA analog 0.39 (0.0 – 31.0)

> >

> > Glycolysis

> >

> > Lactic 1.39 (0.0 – 100.00)

> > Pyruvic 0.91 (0.0 – 50.0)

> > 2-hydroxybutyric 1.22 (0.0 – 2.0)

> > glyceric 0.67 (0.0 – 10.0)

> >

> > Krebs Cycle

> >

> > Succinic 2.02 (0.0 – 20.0)

> > Fumaric 0.10 (0.0 – 10.0)

> > 2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

> > aconitic 6.12 (0.0 – 25.0)

> > citric 810.56 (180.0- 560.0) HIGH

> >

> > Amino Acid Metabolites

> >

> > 2-hydroxyisovaleric 0.00 (0.0 – 2.0)

> > 2-oxoisovaleric 0.00 (0.0 – 2.0)

> > 3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

> > hydroxyisocaproic 0.14 (0.0 – 2.0)

> > 2-oxoisocaproic 0.10 (0.0 – 2.0)

> > 2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

> > mandelic 0.00 (0.0 – 5.0)

> > phenyllactic 0.16 (0.0 – 2.0)

> > phenylpyruvic 2.38 (0.0 – 5.0)

> > homogentisic 0.18 (0.0 – 2.0)

> > 4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

> > 3-indoleacetic 0.79 (0.0 – 10.0)

> >

> > Neurotransmitters

> >

> > HVA 0.89 (0.0 – 3.5)

> > VMA 2.92 (0.0 – 3.5)

> > 5-hydroxyindoleacetic 1.26 (0.0 –20.0)

> >

> > Pyrimidines

> >

> > Uracil 2.24 (0.0 – 22.0)

> > Thymine 0.35 (0.0 – 2.0)

> >

> > Fatty Acid Metabolites

> >

> > 3-hydroxybutyric 0.69 (0.0 – 10.0)

> > acetoacetic 0.89 (0.0 – 10.0)

> > ethylmalonic 1.36 (0.0 – 10.0)

> > methylsuccinic 0.58 (0.0 – 5.0)

> > adipic 0.39 (0.0 – 12.0)

> > suberic 1.77 (0.0 – 2.0)

> > sebacic 0.09 (0.0 – 2.0)

> >

> > Toxic Indicators

> >

> > Pyroglutamic 4.86 (20.0 – 115.0) LOW

> > Orotic 0.22 (0.0 – 3.5)

> > Hydroxyhippuric 0.76 (0.0 – 20.0)

> >

> > Vitamin Indicators

> >

> > Methylmalonic 0.82 (0.0 – 5.0)

> > Ascorbic 4.61 (10.0 – 200.0)

> > Kynurenic 4.91 (0.0 – 2.0) HIGH

> > Methylcitric 0.17 (0.0 – 12.0)

> > Pyridoxic 2.34 (2.0 – 26.0)

> > Pantothenic 7.03 (1.0 – 4.0) HIGH

> >

> > Miscellaneous

> >

> > Glutaric 0.22 (0.0- 2.0)

> > N-acetyl aspartic 0.00 (0.0 – 100.0)

> > 3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

> > glycolic 0.74 (0.0 – 100.0)

> > oxalic 44.91 (0.0 – 100.)

> > malonic 0.57 (0.0 – 10.0)

> > methylglutaric 0.32 (0.0 – 10.0)

> > hippuric 194.57 (10.0 – 400.0)

> > 4-hydroxybutyric 0.77 (0.0 – 5.0)

> > phenylcarboxylic 0.81 (0.0 – 15.0)

> > indole-like compound 5.30 (0.0 – 60.0)

> >

>

[Guest guest]

Hi Rich:

I am doing magnesium shots twice a day plus using a paste now.

Something else I wanted to ask you about superoxide dismutase, are

you familiar with the Life Extension Foundation's SODzyme? Given my

particular situation, would this likely be helpful or harmful for me

to take? The description sounded good in their catalog, but obviously

my situation is not the norm.

thanks,

Helen

> > >

> > > The Great Plains Laboratory just sent me a copy of my 24 hour

> > urine

> > > test results.

> > >

> > > Comments from anyone, esp. Rich, welcome. Reference range is in

> > > parens.

> > >

> > > From what they said in the comments section, glutathione

> > > depletion/deficiency is what is going on. Also low on vitamin

C,

> > that

> > > I can take. I have been on Immune Pro and Goatien for some

time,

> > and

> > > did three bottles of Liposomal GSH, took a break, am doing some

> > more

> > > now. Doesn't seem to do me much good. The high kynurenic acid

is

> a

> > > tryptophan metabolite and I take tryptophan at night, so that

> > > probably explains that.

> > >

> > > Helen

> > >

> > > Organic Acid Profile

> > >

> > > Great Plains Laboratory

> > >

> > > Yeast/Fungal

> > >

> > > Citramalic 0.31 (0.0 –2.0)

> > > 5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

> > > 3-oxoglutaric 0.0 (0.0 –0.5)

> > > furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

> > > furancarbonlglycine 0.52 (0.0 – 60.0)

> > > tartaric 0.35 (0.0 – 16.0)

> > > arabinose 45.21 (0.0 – 47.0)

> > >

> > > Bacterial

> > >

> > > 2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

> > > 4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

> > > HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

> > > VMA analog 0.39 (0.0 – 31.0)

> > >

> > > Glycolysis

> > >

> > > Lactic 1.39 (0.0 – 100.00)

> > > Pyruvic 0.91 (0.0 – 50.0)

> > > 2-hydroxybutyric 1.22 (0.0 – 2.0)

> > > glyceric 0.67 (0.0 – 10.0)

> > >

> > > Krebs Cycle

> > >

> > > Succinic 2.02 (0.0 – 20.0)

> > > Fumaric 0.10 (0.0 – 10.0)

> > > 2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

> > > aconitic 6.12 (0.0 – 25.0)

> > > citric 810.56 (180.0- 560.0) HIGH

> > >

> > > Amino Acid Metabolites

> > >

> > > 2-hydroxyisovaleric 0.00 (0.0 – 2.0)

> > > 2-oxoisovaleric 0.00 (0.0 – 2.0)

> > > 3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

> > > hydroxyisocaproic 0.14 (0.0 – 2.0)

> > > 2-oxoisocaproic 0.10 (0.0 – 2.0)

> > > 2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

> > > mandelic 0.00 (0.0 – 5.0)

> > > phenyllactic 0.16 (0.0 – 2.0)

> > > phenylpyruvic 2.38 (0.0 – 5.0)

> > > homogentisic 0.18 (0.0 – 2.0)

> > > 4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

> > > 3-indoleacetic 0.79 (0.0 – 10.0)

> > >

> > > Neurotransmitters

> > >

> > > HVA 0.89 (0.0 – 3.5)

> > > VMA 2.92 (0.0 – 3.5)

> > > 5-hydroxyindoleacetic 1.26 (0.0 –20.0)

> > >

> > > Pyrimidines

> > >

> > > Uracil 2.24 (0.0 – 22.0)

> > > Thymine 0.35 (0.0 – 2.0)

> > >

> > > Fatty Acid Metabolites

> > >

> > > 3-hydroxybutyric 0.69 (0.0 – 10.0)

> > > acetoacetic 0.89 (0.0 – 10.0)

> > > ethylmalonic 1.36 (0.0 – 10.0)

> > > methylsuccinic 0.58 (0.0 – 5.0)

> > > adipic 0.39 (0.0 – 12.0)

> > > suberic 1.77 (0.0 – 2.0)

> > > sebacic 0.09 (0.0 – 2.0)

> > >

> > > Toxic Indicators

> > >

> > > Pyroglutamic 4.86 (20.0 – 115.0) LOW

> > > Orotic 0.22 (0.0 – 3.5)

> > > Hydroxyhippuric 0.76 (0.0 – 20.0)

> > >

> > > Vitamin Indicators

> > >

> > > Methylmalonic 0.82 (0.0 – 5.0)

> > > Ascorbic 4.61 (10.0 – 200.0)

> > > Kynurenic 4.91 (0.0 – 2.0) HIGH

> > > Methylcitric 0.17 (0.0 – 12.0)

> > > Pyridoxic 2.34 (2.0 – 26.0)

> > > Pantothenic 7.03 (1.0 – 4.0) HIGH

> > >

> > > Miscellaneous

> > >

> > > Glutaric 0.22 (0.0- 2.0)

> > > N-acetyl aspartic 0.00 (0.0 – 100.0)

> > > 3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

> > > glycolic 0.74 (0.0 – 100.0)

> > > oxalic 44.91 (0.0 – 100.)

> > > malonic 0.57 (0.0 – 10.0)

> > > methylglutaric 0.32 (0.0 – 10.0)

> > > hippuric 194.57 (10.0 – 400.0)

> > > 4-hydroxybutyric 0.77 (0.0 – 5.0)

> > > phenylcarboxylic 0.81 (0.0 – 15.0)

> > > indole-like compound 5.30 (0.0 – 60.0)

> > >

> >

>

[Guest guest]

Is this perhaps why when mjh suggested I eat 4 oz of turkey at night,

to try to get sleepy, I felt nothing -- no " effect of trypophan " ?

I think I harbor long-term infection. No telling what, at this

point, other than systemic fungal.

the one in Champaign IL

> >

> > Hi, Helen.

> >

> > Your results are very characteristic of glutathione depletion,

> > showing up both in your skeletal muscle cells and in your kidneys.

> >

> > The high citric and low 2-oxo-glutaric acids, together with the

> > other Krebs metabolites being on the low end of normal says that

> > there is a partial blockade in your Krebs cycle just beyond

citric

> > acid. It is building up in front of the blockade, and the

> > metabolites beyond the blockade are all low. Glutathione

depletion

> > gives rise to elevation of superoxide and probably peroxynitrite

as

> > well, and both are able to react with aconitase and lower its

> > activity. This can explain those results. Since the skeletal

> > muscle cells represent a large fraction of the body's cellular

mass,

> > and the urine carries metabolites from all the cells, it is

likely

> > that these results reflect what is going on in the skeletal

muscle

> > cells, especially if you have physical fatigue, which would be

> > consistent with this.

> >

> > In addition, you have low pyroglutamic acid. In the urine this

> > primarily reflects what is going on in the kidneys, since the

> > kidneys are the main organ that carries on the gammaglutamyl

cycle,

> > in which pyroglutamic acid is produced from glutathione. The

fact

> > that your pyroglutamic acid is low shows that your kidneys are

> > depleted in glutathione as well.

> >

> > I have not seen a more clearcut case before.

> >

> > With your arabinose as high as it is, I suspect that you have a

> > yeast infection. This is consistent with having low glutathione,

> > because glutathione is needed to support cell-mediated immunity,

> > which is necessary to defeat yeast infections.

> >

> > It looks as though your ascorbic acid is low, too, although it

> > doesn't say " LOW " next to it (however, you did say that it is

low,

> > so I'm guessing that you typed the numbers correctly and just

left

> > out the " LOW " ). With as low a glutathione level as you appear to

> > have, I am not surprised that ascorbate (vitamin C) is also very

> > low, because when glutathione is badly depleted, there is not

enough

> > available to recycle the vitamin C, and it goes down, too. Note

> > that glutathione is at the basis of the entire antioxidant enzyme

> > system in the body. It appears that your body is in a fairly

severe

> > state of oxidative stress.

> >

> > The elevated kynurenic acid suggests that your body is low in the

> > active form of vitamin B6, which is P5P. This could be because

you

> > are low in B6, or it could be that your body is not able to

convert

> > B6 to the active form, P5P, very well.

> >

> > It's possible that this latter problem is what's responsible for

> > your low glutathione as well, because P5P is important as a

coenzyme

> > for enzymes in the transsulfuration pathway, which produce

cysteine,

> > which is the rate-limiting amino acid for making glutathione.

> >

> > I don't know why your pantothenic acid (vitamin B5) is high,

unless

> > you are taking a lot of it as a supplement.

> >

> > I would suggest that you try taking some P5P. Start low, and

work

> > up to say, 30 mg, and observe whether you experience improvement

in

> > your symptoms.

> >

> > Rich

> >

[Guest guest]

I take 1000 mgs of tryptophan every night to help me sleep. Until

recently it was 1500 mgs. Maybe that's why I got that one reading

about the tryptophan metabolite.

Helen

> > >

> > > The Great Plains Laboratory just sent me a copy of my 24 hour

> > urine

> > > test results.

> > >

> > > Comments from anyone, esp. Rich, welcome. Reference range is in

> > > parens.

> > >

> > > From what they said in the comments section, glutathione

> > > depletion/deficiency is what is going on. Also low on vitamin

C,

> > that

> > > I can take. I have been on Immune Pro and Goatien for some

time,

> > and

> > > did three bottles of Liposomal GSH, took a break, am doing some

> > more

> > > now. Doesn't seem to do me much good. The high kynurenic acid

is a

> > > tryptophan metabolite and I take tryptophan at night, so that

> > > probably explains that.

> > >

> > > Helen

> > >

> > > Organic Acid Profile

> > >

> > > Great Plains Laboratory

> > >

> > > Yeast/Fungal

> > >

> > > Citramalic 0.31 (0.0 –2.0)

> > > 5-hydroxymethyl-2-furoic 2.26 (0.0 – 80.0)

> > > 3-oxoglutaric 0.0 (0.0 –0.5)

> > > furan-2,5-dicarboxylic 2.87 (0.0 –50.0)

> > > furancarbonlglycine 0.52 (0.0 – 60.0)

> > > tartaric 0.35 (0.0 – 16.0)

> > > arabinose 45.21 (0.0 – 47.0)

> > >

> > > Bacterial

> > >

> > > 2-hydroxyphenylacetic 0.25 (0.0 – 10.0)

> > > 4-hydroxyphenylacetic 3.28 (0.0 – 50.0)

> > > HPHPA (DHPPA-A) 17.18 (0.0- 150.0)

> > > VMA analog 0.39 (0.0 – 31.0)

> > >

> > > Glycolysis

> > >

> > > Lactic 1.39 (0.0 – 100.00)

> > > Pyruvic 0.91 (0.0 – 50.0)

> > > 2-hydroxybutyric 1.22 (0.0 – 2.0)

> > > glyceric 0.67 (0.0 – 10.0)

> > >

> > > Krebs Cycle

> > >

> > > Succinic 2.02 (0.0 – 20.0)

> > > Fumaric 0.10 (0.0 – 10.0)

> > > 2-oxo-glutaric 10.62 (15.0 – 200.0) LOW

> > > aconitic 6.12 (0.0 – 25.0)

> > > citric 810.56 (180.0- 560.0) HIGH

> > >

> > > Amino Acid Metabolites

> > >

> > > 2-hydroxyisovaleric 0.00 (0.0 – 2.0)

> > > 2-oxoisovaleric 0.00 (0.0 – 2.0)

> > > 3-methyl-2-oxovaleric 1.06 (0.0 – 2.0)

> > > hydroxyisocaproic 0.14 (0.0 – 2.0)

> > > 2-oxoisocaproic 0.10 (0.0 – 2.0)

> > > 2-oxo-4-methiobutyric 0.25 (0.0 – 2.0)

> > > mandelic 0.00 (0.0 – 5.0)

> > > phenyllactic 0.16 (0.0 – 2.0)

> > > phenylpyruvic 2.38 (0.0 – 5.0)

> > > homogentisic 0.18 (0.0 – 2.0)

> > > 4-hydroxyphenyllactic 0.44 (0.0 – 50.0)

> > > 3-indoleacetic 0.79 (0.0 – 10.0)

> > >

> > > Neurotransmitters

> > >

> > > HVA 0.89 (0.0 – 3.5)

> > > VMA 2.92 (0.0 – 3.5)

> > > 5-hydroxyindoleacetic 1.26 (0.0 –20.0)

> > >

> > > Pyrimidines

> > >

> > > Uracil 2.24 (0.0 – 22.0)

> > > Thymine 0.35 (0.0 – 2.0)

> > >

> > > Fatty Acid Metabolites

> > >

> > > 3-hydroxybutyric 0.69 (0.0 – 10.0)

> > > acetoacetic 0.89 (0.0 – 10.0)

> > > ethylmalonic 1.36 (0.0 – 10.0)

> > > methylsuccinic 0.58 (0.0 – 5.0)

> > > adipic 0.39 (0.0 – 12.0)

> > > suberic 1.77 (0.0 – 2.0)

> > > sebacic 0.09 (0.0 – 2.0)

> > >

> > > Toxic Indicators

> > >

> > > Pyroglutamic 4.86 (20.0 – 115.0) LOW

> > > Orotic 0.22 (0.0 – 3.5)

> > > Hydroxyhippuric 0.76 (0.0 – 20.0)

> > >

> > > Vitamin Indicators

> > >

> > > Methylmalonic 0.82 (0.0 – 5.0)

> > > Ascorbic 4.61 (10.0 – 200.0)

> > > Kynurenic 4.91 (0.0 – 2.0) HIGH

> > > Methylcitric 0.17 (0.0 – 12.0)

> > > Pyridoxic 2.34 (2.0 – 26.0)

> > > Pantothenic 7.03 (1.0 – 4.0) HIGH

> > >

> > > Miscellaneous

> > >

> > > Glutaric 0.22 (0.0- 2.0)

> > > N-acetyl aspartic 0.00 (0.0 – 100.0)

> > > 3-hydroxy-3-methylglutaric 2.76 (0.0 – 36.0)

> > > glycolic 0.74 (0.0 – 100.0)

> > > oxalic 44.91 (0.0 – 100.)

> > > malonic 0.57 (0.0 – 10.0)

> > > methylglutaric 0.32 (0.0 – 10.0)

> > > hippuric 194.57 (10.0 – 400.0)

> > > 4-hydroxybutyric 0.77 (0.0 – 5.0)

> > > phenylcarboxylic 0.81 (0.0 – 15.0)

> > > indole-like compound 5.30 (0.0 – 60.0)

> > >

> >

>