Doxycycline & Tendonitis ?

[Guest guest]

Hello All,

Has anyone experienced tendonitis associted the use of

doxycycline? I've found no listing of it as a

recognized side effect, nor studies or case reports

suggesting such a link. For what it's worth, I did

find a hearsay anecdotal report. [1] Nevertheless,

there seems to be a prima-facie basis in theory for

such a doxycycline / tendonitis link.

Doxycycline is a broad spectrum matrix

metalloproteinases inhibitor (MMPi).[2,3] The role of

MMP includes maintenance (breakdown and rebuilding) of

tendon tissue, [4] which is essential for wound

healing. [5] Naturally, MMPi can impair such healing.

Discussing the class of known MMPi's and expressly

including doxycycline in that class, (2006)

observes that:

" Early clinical studies with MMPi's revealed a severe

adverse side-effect frequently referred to as the

musculoskeletal syndrome (MSS). [...] This review

describes MSS, the tendonitis-like, dose-limiting

side-effect [...] Ironically, a class of drugs

[MMPi's] developed to treat arthritis, among other

conditions, induces a tendonitis-like fibromylagia or

musculoskeletal syndrome (MSS) in humans. " [6]

And other substances with adverse effects on tendons

have had their effects attributed to their being

MMPi's. [7] So the evidence seems to suggest the

possibility that doxycycline could impair healing of

lyme-wounded tendons and promote a tendonitis-like

fibromylagia. Hopefully that's not the case, and like

I say, I've found no recognized connection.

But a corollary issue that arises is the possibility

that doxycycline could induce symptoms that so closely

resemble lyme symptoms (since MMPi's " induce a

tendonitis-like fibromylagia " ), the side effects could

in some be interpreted as a persistence of lyme and

thus evade detection as mere drug side effects. This

is of course just theory, though it seems plausible to

me. And btw, this is my first post. I live in

Rockville, MD, and a lyme test for me is off to the

lab. Since I have widespread tendonitis, so I've been

concerned about embarking upon doxycycline treatment

for afore cited reasons. ~Ian

_____________________________________________________

[1] " Judy took Doxycycline and had three weeks of

progressive tendonitis before a ligament in her hip

tore during sleep. "

http://www.dfwcfids.org/help/default.htm

[2]

http://atvb.ahajournals.org/cgi/content/full/23/3/483

[3]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve & db=pubmed & list_uids=9\

972117

[4]

http://en.wikipedia.org/wiki/Matrix_metalloproteinase

[5]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

2706016

[6]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6413004

[7]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6636352

__________________________________________________

[Guest guest]

I personaly can not see any connection between the two. having used Doxycycline

the only mistake I made was I felt better and over did itl. If your tendonitis

is there then I would go slow as for a link I due not feel that it there.

Bud

Ian Goddard <iamgoddard@...> wrote: Hello All,

Has anyone experienced tendonitis associted the use of

doxycycline? I've found no listing of it as a

recognized side effect, nor studies or case reports

suggesting such a link. For what it's worth, I did

find a hearsay anecdotal report. [1] Nevertheless,

there seems to be a prima-facie basis in theory for

such a doxycycline / tendonitis link.

Doxycycline is a broad spectrum matrix

metalloproteinases inhibitor (MMPi).[2,3] The role of

MMP includes maintenance (breakdown and rebuilding) of

tendon tissue, [4] which is essential for wound

healing. [5] Naturally, MMPi can impair such healing.

Discussing the class of known MMPi's and expressly

including doxycycline in that class, (2006)

observes that:

" Early clinical studies with MMPi's revealed a severe

adverse side-effect frequently referred to as the

musculoskeletal syndrome (MSS). [...] This review

describes MSS, the tendonitis-like, dose-limiting

side-effect [...] Ironically, a class of drugs

[MMPi's] developed to treat arthritis, among other

conditions, induces a tendonitis-like fibromylagia or

musculoskeletal syndrome (MSS) in humans. " [6]

And other substances with adverse effects on tendons

have had their effects attributed to their being

MMPi's. [7] So the evidence seems to suggest the

possibility that doxycycline could impair healing of

lyme-wounded tendons and promote a tendonitis-like

fibromylagia. Hopefully that's not the case, and like

I say, I've found no recognized connection.

But a corollary issue that arises is the possibility

that doxycycline could induce symptoms that so closely

resemble lyme symptoms (since MMPi's " induce a

tendonitis-like fibromylagia " ), the side effects could

in some be interpreted as a persistence of lyme and

thus evade detection as mere drug side effects. This

is of course just theory, though it seems plausible to

me. And btw, this is my first post. I live in

Rockville, MD, and a lyme test for me is off to the

lab. Since I have widespread tendonitis, so I've been

concerned about embarking upon doxycycline treatment

for afore cited reasons. ~Ian

_____________________________________________________

[1] " Judy took Doxycycline and had three weeks of

progressive tendonitis before a ligament in her hip

tore during sleep. "

http://www.dfwcfids.org/help/default.htm

[2]

http://atvb.ahajournals.org/cgi/content/full/23/3/483

[3]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve & db=pubmed & list_uids=9\

972117

[4]

http://en.wikipedia.org/wiki/Matrix_metalloproteinase

[5]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

2706016

[6]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6413004

[7]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

6636352

__________________________________________________