Guest guest Posted December 4, 2010 Report Share Posted December 4, 2010 I thought LDN was supposed to block your opioid receptors only at night, then by day time you're producing more opioids in over drive. If that is so, why is it that when I took Vicodin for a neck strain in the late afternoon, it did absolutely nothing for my pain. I even took a second, and nada. It seems that the LDN is blocking my opioids even late in the day - so when is my up-regulation of opioids happening? Also today I had a few drinks of alcohol and felt nothing - it makes me feel like the LDN is blocking my opioids around the clock instead of causing a boost after it wears off. How do I know it's actually working to BOOST my opioids if instead it just seems to be blocking them 100% of the time. I got this filled at Irmat so I know it wouldn't be time release. Has anyone noticed this, or thought about what it means? Quote Link to comment Share on other sites More sharing options...
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