RE: Insomnia :( transdermal LDN

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It sounds like you need to take LDN really slowly and build up gradually. Perhaps you should stop taking LDN for a while until you get stable and then start taking LDN once week. Everyone has to experiment and find their own dose especially if you are sensitive. I would strongly recommend you take LDN transdermally – this meant to minimize side effects because it by passes the liver on the first round – I wish I had done this as I could have avoided a lot of difficulties. I had months of really poor sleeping, hot hands & then spasms at night & spasticity. Transdermal has other benefits too :1 immediate absorption2 do not need to take it with food3 easier to adjust the dose up or down as you need Your compounding chemist can make up transdermal LDN. I specify that they use emu oil as a base as Dr McCandles says it is the best (it is a bit more expensive) but you could specify a cream you know is good for you.. I like transdermal because the uptake is very quick and it allows me to avoid the fillers which I tend to be allergic to. When you get a scrip tell the doctor you want 4.5ml so you can try the higher dose, with the transdermal LDN it is easy to vary the dose (up & down), so you can always start low and go up a little at a time. Just so you know that there others who have struggled I will tell you my LDN story.I have had SPMS for 15 years & RRMS since 15 years old and saw the a lot of improvements over the first 7 months taking LDN 3.00mg:Flexibility of leg, first improvement which started after 2 weeks on LDN, (the other improvements followed gradually) can kneel for the first time in 15yearsImproved strength and balance of left leg, can stand balanced on both legs for the first time in many years (not very well). Combination of improved flexibility, strength & balance has lead to improvement in mobility, Regained 80-90% of smell and taste which I lost nearly completely for 3 years, feel really good/cheerfulImproved co-ordination of left hand. When I first regained it a few months after I started taking LDN I could type perfectly. Then I lost it due to allergic reaction to LDN & now I have the improved co- ordination but weakness of hand negatively impacts on the co-ordination. Have totally regained normal speaking - I had been gradually losing both the strength/projection of my voice for the last 2 years. Raising my voice and even talking was often an effort – now I am told not to talk so loud!Choking – much, much improved none in last few monthsPins & needles and flares of pain like being jabbed with a needle – none in last five monthsNo colds/flu & no bouts of sinus (which used to be a constant problem & lead to exacerbation of MS – LDN boosts immune system)Bladder improved Then I had to stop LDN because of allergic reactions. After I had been off LDN for more than 2 months I had started LOSING the benefits. The following happened – flexibility & mobility much less, post nasal drip returned, some choking, loss of smell, pain flares in toesL Then, after another month, I restarted LDN taking 2.00 mg of LDN transdermally but spasms started from 3am (painless but intense) & the spasticity when I got up in the morning was so bad I could hardly walk, couldn’t sit & this lasted until 10 am. So I started trying varying the dose every way I could think of but spasms & the spasticity still persisted at intolerable levels. I finally found 4.5mg once a week worked. Over the next month I gradually increased it and I currently take 4.5mg, transdermally, every night BUT I restarted taking LDN only once a week.LDN has been magical for me, just persist & be patient. Good luck Trish From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of SvenSent: Thursday, 2 December 2010 3:02 AMlow dose naltrexone Subject: [low dose naltrexone] Insomnia I just started taking LDN. I took half of 4.5 LDN on Sunday night. I am 115 pound women, 5'5. I slept lightly with strange dreams, Monday night I took it again with 400mg of magnesium. I slept a little better. Last night, I took it with magnesium but had insomnia. I also noticed my joint and muscle pain in my knees and hands was worse after it kicked in, like a tingle. I had to take melatonin at 3:30am and finally fell asleep at 4am..but my kids get up at 6am. I cannot take melatonin often because it makes me bloated and achy for some reason. I also do not want to rely on anything to fall asleepI am SO sad, I really wanted to give this 6 months. My doc said I can take it in the AM, but I know a lot of people out there say it does nothing if taken in the AM. I dont see how it would do anything at night if I am not sleeping either though.I am thinking of breaking my 4.5 half in another half tonight, although I am scared.Has anyone had this and had it pass? Any suggestions?I suffer from a disease called interstitial cystitis, which doctors do not understand well. My doc thinks its an autoimmune disorder. Also I have lots of joint and muscles pains and MANY other wired symptoms in my body, along with gut issues.