Re: LDN Cream-Response from LDN Science.org

[Guest guest]

Does anyone know if hot flashes are a side effect of LDN??

[low dose naltrexone] LDN Cream-Response from LDN Science.org

 

I have been very interested in the LDN cream because I've had some side effects

from LDN pill (at 2mg) - horrible hot flushing, morning digestive issues and

sleep problems. Thank you for the members who have emailed me directly about

your positive effects of LDN cream. Also, a BIG thanks to Skip for emailing me

the directions for LDN cream - my psychiatrist is writing my scripts as a favor

because I can't find an educated doctor in my area. I sent a question to LDN

Science.org about taking LDN transdermally and below is the response I recevied

from them. Does this sound accurate? It kinda makes sense for a patch but NOT

cream. Now I'm very discouraged............am off of LDN because of side effects

and thought the cream would be the answer.

ANSWER FROM LDNSCIENCE.ORG:

For LDN to work, the full LDN dose must be delivered to the body in one go.

Transdermal delivery methods by nature result in slow continuous delivery of a

drug. This will result in continuous opiate receptor blockade - quite the

opposite of the purpose of LDN which is to deliver a very short term blockade in

order to create the beneficial rebound effect.

When I was taking LDN capsules I was also taking an occasional vicodin if

afternoon pain was not controlled and I had NO interference. It sounds like that

would be impossible with the cream.

Any input would be helpful.Am taking LDN for fibromyalgia and CFS. Trying so

darn hard to get my life back.

Pam

[Guest guest]

TD(Transdermal LDN)

http://ldn.proboards.com/index.cgi?board=forum & action=display & thread=401

>

> I have been very interested in the LDN cream because I've had some side

effects from LDN pill (at 2mg) - horrible hot flushing, morning digestive issues

and sleep problems. Thank you for the members who have emailed me directly

about your positive effects of LDN cream. Also, a BIG thanks to Skip for

emailing me the directions for LDN cream - my psychiatrist is writing my scripts

as a favor because I can't find an educated doctor in my area. I sent a question

to LDN Science.org about taking LDN transdermally and below is the response I

recevied from them. Does this sound accurate? It kinda makes sense for a patch

but NOT cream. Now I'm very discouraged............am off of LDN because of

side effects and thought the cream would be the answer.

> ANSWER FROM LDNSCIENCE.ORG:

> For LDN to work, the full LDN dose must be delivered to the body in one go.

Transdermal delivery methods by nature result in slow continuous delivery of a

drug. This will result in continuous opiate receptor blockade - quite the

opposite of the purpose of LDN which is to deliver a very short term blockade in

order to create the beneficial rebound effect.

>

> When I was taking LDN capsules I was also taking an occasional vicodin if

afternoon pain was not controlled and I had NO interference. It sounds like

that would be impossible with the cream.

>

> Any input would be helpful.Am taking LDN for fibromyalgia and CFS. Trying so

darn hard to get my life back.

>

> Pam

>

[Guest guest]

Sometimes people should state that "based on my opinion, or in my opinion " or some such terminology. Some drugs will act as if they are sustained released when administered transdermally due to lipophyllic characteristics. On the other hand if applied to a non-adipose area, and over a blood source close to the skin, then the drug will rapidly disperse through out the blood stream. Finally, Dr. Jackie has had several years experience with the TD form and has found it be very efficient. I don't know where this web site came from, but after reviewing it, there is a lot of theory there which may or may not be true.

Dr.Skip

[Guest guest]

So the cream should be applied to thinner tissue like say, the neck or back of

hands? I was told to apply it to soft areas like the abdomen or inside of the

legs and arms.

>

> Sometimes people should state that " based on my opinion, or in my opinion "

> or some such terminology. Some drugs will act as if they are sustained

> released when administered transdermally due to lipophyllic characteristics.

> On the other hand if applied to a non-adipose area, and over a blood

> source close to the skin, then the drug will rapidly disperse through out the

> blood stream. Finally, Dr. Jackie has had several years experience with the

> TD form and has found it be very efficient. I don't know where this web

> site came from, but after reviewing it, there is a lot of theory there which

> may or may not be true.

> Dr.Skip

>