Guest guest Posted November 23, 2010 Report Share Posted November 23, 2010 I have been on LDN 1.5mg caps for 5 weeks, and recently moved up to 3.0mg.I have polymyositis, which affects a lot of muscles. On my last visit to my rheumatologist, based on some tests (CReactiveProtein, ESR), he asked me to take methotrexate 15mg via IV subcutaneous self injection one a week. My next injection is due this Thu (TGiving). I am also on 5mg prednisone. Question: don't methotrexate and LDN work in opposite ways? How much methotrexate would be ok to take with LDN. Thanks /Nara Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2011 Report Share Posted February 21, 2011 Celia I have shared a few, but I believe this is the one you are referring to:- Dear Jayne: This paper on B lymphocytes - and the next on T lymphocytes - is chuck full of science. Most importantly: 1. OGF suppresses B cell proliferation - this means it is an immunosuppressant (not an immunostimulant as many claimed - without substance). Of course, you would not want an immunostimulant if you already have heightened immune response as in autoimmunity - this would only make things worse. OGF is a natural - native - immunosuppressant unlike all of the others (look at the treatments for MS or Crohn's). 2. OGF is an opioid peptide. No other opioid peptide alters cell proliferation. 3. OGF works through the OGF receptor. The proof - if we " knockdown " each of the opioid receptors (there are 3 classical and 1 (OGFr) non classical - with what are called siRNAs (they gave the Nobel prize for this discovery a few years back), OGF still has an effect with each of the classical opioid receptors but no effect in the presence of the siRNA for OGFr. In other words, OGFr is the receptor for OGF in the case of B lymphocyte proliferation. 4. Both OGF-like peptide and OGFr are detected on B cells. 5. If you try and remove either OGF (using an antibody - bottom of Fig. 4) or siRNA for OGFr or naltrexone, there is no increase in cell number. This is the first time we have seen this. Normally OGF and OGFr are interacting as a self-regulatory unit to control cell proliferation. In other words they are always talking. In B cells this is not the case. You can add OGF and depress cell proliferation via OGFr, but these two do not regulate B cell replication. Why? Because the body respects " self " - so that there is no inside regulation - it has to be by a far more complicated process (what are called antigen presenting phenomena). 6. OGF does not kill cells to repress growth. It works through a complicated pathway we discovered to delay cells in proliferation (this is called the cyclin-dependent inhibitory kinase pathway). Dr. ZagonI have both papers showing that B cells and T cells are suppressors. My offer as before still stands, if anyone would like a copy, just email me and I’ll be happy to send them to you. There’s also this Dear Jayne: LDN - and OGF - are immunesuppressors. That is how they work so nicely for autoimmune diseases. For cancer, they increase the inhibitors of the cell cycle - and produce less cells.Dr. Zagon Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Celia DanksSent: 21 February 2011 20:26low dose naltrexone Subject: Re: [low dose naltrexone] Re: LDN and methotrexate Jayne, that is why Zagon will not participate in groups, but avails himself for all who wish to question him, he sent you a great mail which I can't find, and in it I think he said LDN was not a modulator, but rather an immune supressive, can you find that mail? I hope I have remembered correctly......Thanks lotsCeliax Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2011 Report Share Posted February 21, 2011 Thanks Jayne, the bottom one was the one and thanks for resending it, much appreciated, I hope folks really read that one - " LDN and OGF - are immune suppressors. That is how they work so nicely for autoimmune diseases. For cancer, they increase the inhibitors of the cell cycle - and produce less cells." Spot on Jayne, just what I thought, and yet we still have people on here saying it is a modulator/stimulator and so on, methinks maybe this should be posted at regular intervals!!!!:-))) Good one Jayne and thanks....... Celia x Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 22, 2011 Report Share Posted February 22, 2011 I wonder if there is any definitive email or word from Dr. Zagon about the degree of difference in effectiveness with LDN in the morning or taken in the evening. I know the general consensus is that night is more effective but how much more effective? Helen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 22, 2011 Report Share Posted February 22, 2011 Emiliano, Sorry to bring this up again, but one thing I forgot to post with regards to LDN and steroids which I think is important is this (taken from the LDNScience.org site) Naltrexone is not a steroid and not related to steroids in any way. Furthermore it does not have any direct effect on the hormonal system, so it does not interfere with the activity of steroids in any way. I hope the above clarifies the query re LDN and steroids should you be asked if LDN can be taken in conjunction with steroids Best, Jayne Crocker www.LDNNow.comImportant! Please sign our LDN petition to the European Parliament by clicking heretel: +44 (0) 7877 492 669Dr Steele MBE, talking about LDNLDNNow are a political/pressure group of individuals dedicated to getting Low Dose Naltrexone (LDN) accepted into modern medicine and trialled for the myriad of uses it shows benefit for. . From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of emilnariSent: 21 February 2011 12:51low dose naltrexone Subject: [low dose naltrexone] Re: LDN and methotrexate relevant to ldn and steroids i can only say thati received a mail from dr.Bob Lawrence exactly 6 months ago,and he sent me a medical documents done by his studio where was clearly written that steroids and ldn should not be taken together due to the immunesupressant power of steroids that reduce ldn effect .furthermore he suggested to use antioxidants in abundance(the documents title was :what shall i do if i need steroids?)the beginning of the documentes was :the answer is easy,you do not need streroids.another important reason for wich is better stay away from steroids is the damage created to bone structures.my old neurologist(the one that agree with my decision to start ldn)that unfortunately dead two years ago for a pancreatic cancer,has never prescribed me steroids due to bone damaging.i know that it is possible to find different opinion,and i know that due to this possibility there are patz that can get different way.but i can write my experience,i'm not doing steroids since 2007 and i'm taking ldn + a lot of antioxidants(ala,lac,vit.b,vit.d3,mangostano juice,niancin and i drink only green thea 2 lt a day) well i never needed it and the few time i had a relapseit went away after several days without doing steroids but encreasing antioxidants.now it is more than 2 years that i do not have one.of course anyone is free to decide what is better for his healthmy bestemiliano Quote Link to comment Share on other sites More sharing options...
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