Lyme Uveitis

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Here are a few abstracts on Uveitis and Lyme. There are many more out there

detailing the ocular manifestations of Lyme but I don't want to inundate the

list. Hope this helps.

" CONCLUSIONS: We emphasize the importance of performing serological tests for

borreliosis in patients with uveitis, inflammatory diseases of unknown

etiology, optic neuritis and other neuro-ophthalmic conditions. "

Title: [Clinical manifestation and diagnosis of ocular borreliosis]

Authors: Biziorek B, Zagorski Z, Jedrzejewski D, Haszcz D

Source: Klin Oczna 1997;99(2):129-32

Organization: Katedry i l Kliniki Okulistyki AM w Lublinie.

Abstract:

PURPOSE: To present severe involvements of Borrelia burgdorferi in the

etiology

of uveitis, optic neuritis and other ocular inflammatory conditions. METHODS:

IgM and IgG antibodies for Borrelia burgdorferi were detected by ELISA. Since

May 1995 we have examined 78 patients for borreliosis. RESULTS: Borreliosis

was

diagnosed in 11 patients (4 males, 7 females; aged 7 to 48). 7 persons

remembered being bitten by a tick, 3 months to 3 years before the onset of

ocular symptoms. All patients had systemic symptoms and signs. Ocular

manifestations were as follows: nonspecific chronic conjunctivitis in 4

patients, keratitis in 2, diminished corneal sensation in 1, iritis in 1,

intermediate uveitis and perivasculitis in 1, posterior uveitis in 3, retinal

haemorrhage in 1, optic neuritis in 1, optic disc oedema in 2, sixth nerve

paresis in 1 patient. CONCLUSIONS: We emphasize the importance of performing

serological tests for borreliosis in patients with uveitis, inflammatory

diseases of unknown etiology, optic neuritis and other neuro-ophthalmic

conditions.

Language: Pol

Unique ID: 98016894

" ..CONCLUSIONS: Late-phase ocular Lyme borreliosis is probably underdiagnosed

... "

Title: Diagnosis and clinical characteristics of ocular Lyme borreliosis.

Authors: Karma A, Seppala I, Mikkila H, Kaakkola S, Viljanen M, Tarkkanen A

Source: Am J Ophthalmol 1995 Feb;119(2):127-35

Organization: Department of Ophthalmology, University of Helsinki, Finland.

Abstract:

PURPOSE: To establish a diagnosis, in a group of patients we studied the

characteristics of ocular Lyme borreliosis. METHODS: During a two-year period,

236 patients with prolonged external ocular inflammation, uveitis, retinitis,

optic neuritis, or unexplained neuro-ophthalmic symptoms were examined for

Lyme

borreliosis. Antibodies to Borrelia burgdorferi were measured by indirect

ELISA

and western blot. Cerebrospinal fluid was also analyzed by polymerase chain

reaction. RESULTS: Ocular Lyme borreliosis was diagnosed in ten patients on

the

basis of medical history, clinical findings, and serologic test results.

Results of ELISA disclosed that five patients were seropositive, two patients

showed borderline reactivity, and three patients were seronegative. Four of

the

five patients with borderline or negative results by ELISA had a positive

result by western blot analysis. In one seropositive patient, polymerase chain

reaction verified a gene of B. burgdorferi endoflagellin from the vitreous and

cerebrospinal fluid specimen. In five of the six patients with known onset of

the Borrelia infection, the ocular disorder appeared as a late manifestation.

Abnormalities of the posterior segment of the eye, such as vitreitis, retinal

vasculitis, neuroretinitis, choroiditis, and optic neuropathy were seen in six

patients. Bilateral paralytic mydriasis, interstitial keratitis, episcleritis,

and anterior uveitis were seen in one patient each. CONCLUSIONS: Late-phase

ocular Lyme borreliosis is probably underdiagnosed because of weak

seropositivity or seronegativity in ELISA assays. Ocular borrelial

manifestations show characteristics resembling those seen in syphilis.

Language: Eng

Unique ID: 95133613

Title: The etiology of uveitis: the role of infections with special reference

to Lyme borreliosis.

Authors: Mikkila H, Seppala I, Leirisalo-Repo M, Immonen I, Karma A

Source: Acta Ophthalmol Scand 1997 Dec;75(6):716-9

Organization: Department of Ophthalmology, University of Helsinki, Finland.

Abstract:

PURPOSE: To assess the distribution of different uveitis entities and to

evaluate their associations with infections, especially Lyme borreliosis.

METHODS: During a one-year period 160 consecutive uveitis patients were

evaluated in a university clinic. Selected tests were performed depending on

the medical history of the patient and the clinical picture of the ocular

inflammation. RESULTS: Uveitis was classified into selected entities for 74.4%

of the patients. A direct infection was suggested to be linked with uveitis in

23 patients (14.4%). Lyme borreliosis, toxoplasmosis, and herpetic infections

were the most frequently seen, in seven patients (4.3%) each. All patients

with

Lyme uveitis had manifestations of the posterior segment of the eye, such as

vitritis, retinal vasculitis, neuroretinitis, chorioretinitis, or optic

neuropathy. CONCLUSION: Infections are an important cause of uveitis in a

university clinic. Lyme borreliosis is a newly recognised uveitis entity which

should be kept in mind in the differential diagnosis of intermediate or

posterior uveitis in areas endemic for Lyme borreliosis.

Language: Eng

Unique ID: 98186569

Title: [Ocular involvement in Lyme disease]

Authors: Michalov:a K, R:ihov:a E, Poch T

Source: Cesk Oftalmol 1993 Apr;49(2):101-4

Organization: I. o:cn:i klinika FN 2 s FP, Praha.

Abstract:

Lyme disease is a tick-born multisystemic disease, caused by the Spirochete

Borrelia burgdorferi. We examined and treated a 60-year-old woman, who 6

months

after a tick bite had developed bilateral uveitis, with the involvement of the

anterior segment, vitreous opacities and retinal vasculitis. The ocular

involvement was, besides the skin lesion in the first stage of the disease,

the

only systemic manifestation of the infection.

Language: Cze

Unique ID: 93258835

Title: Ocular Lyme disease: case report and review of the literature.

Authors: Kauffmann DJ, Wormser GP

Source: Br J Ophthalmol 1990 Jun;74(6):325-7

Organization: New York Medical College, Valhalla 10595.

Abstract:

Lyme disease is an emerging new spirochaetal disease in which ocular

complications may arise. We have seen a 45-year-old woman who developed

unilateral endophthalmitis leading to blindness during the course of this

disease. Ocular tissue showed the characteristic spirochete. A literature

review shows that the commonest ocular manifestation of Lyme disease is a mild

conjunctivitis, but other symptoms may include periorbital oedema, oculomotor

palsies, uveitis, papilloedema, papillitis, interstitial keratitis, and

others.

Ophthalmologists treating patients from Lyme disease endemic areas need to be

aware of the protean clinical manifestation of this disease.

Language: Eng

Unique ID: 90335153