RE: LDN & MS pain/spasms/spasticity - SUCCESS

[Guest guest]

Hi Sue

I have had SPMS for 15 years & RRMS since 15

years old and have seen the following improvements over the last 7 months since

taking LDN:

1 Flexibility

of leg, first improvement which started after 2 weeks on LDN, (the other improvements

followed gradually) at first only in the middle of the night (after

taking LDN after 9pm) now all day as well – can kneel for the first time

in 15 years

2 Improved

strength and balance of left leg, can stand balanced on both legs for the

first time in many years (not very well). Combination of improved

flexibility, strength & balance has lead to improvement in mobility

3 Regained

80-90% of smell and taste which I lost nearly completely for 3 years

4 Improved

co-ordination of left hand. When I first regained it a few months

after I started taking LDN I could type perfectly. Then I lost it due to

allergic reaction to LDN & now I have the improved co- ordination but

weakness of hand negatively impacts on the co-ordination. Little &

ring finger the weakest.

5 Have

totally regained normal speaking - I had been gradually losing both the

strength/projection of my voice for the last 2 years. Raising my

voice and even talking was often an effort – now I am told not to talk so

loud!

6 Choking

– much, much improved none in last few months

7 Pins

& needles and flares of pain like being jabbed with a needle –

none in last five months

8 No

colds/flu & no bouts of sinus (which used to be a constant problem

& lead to exacerbation of MS – LDN boosts immune system)

9 Bladder

improved

10 Feel really

good/cheerful (LDN releases endorphins)

BUT I had to stop LDN because of increasing severe

spasms & intense pain all day & night. I have a baclofen pump

that usually controls the pain & spasms but after having numerous tests a

dye pumpogram showed that all the baclofen was leaking into the gut through a

hole & not going down the spine. I had to go into hospital for a new

catheter. Finally have no spasms/pain but becuse I had been off LDN for

more than 2 months I had started LOSING the benefits. The following

happened – flexibility & mobility much less, post nasal drip

returned, some choking, loss of smell, pain flares in toesL

Then I restarted LDN taking 2.00 mg of LDN transdermally but

spasms started from 3am (painless but intense) & the spasticity when I got

up in the morning was so bad I could hardly walk, couldn’t sit & this

lasted until 10 am. So I started trying varying the dose every way I

could think of but spasms & the spasticity still persisted at intolerable

levels.

FINALLY SUCCESS - I currently take 4.5mg once a week.

Spasms and spasticity are reduced 80% (both intensity & frequency). The

night I take LDN they are often worse. BEST OF ALL my sense of

smell started coming back immediately – smelt coffee and the stuff the

floor was cleaned with – so wonderful when you regain things you had

lost.

I would strongly recommend he takes it

transdermally - meant to minimize side effects because it by passes the liver

on the first round – transdermal has other benefits too :

1

immediate

absorption

2

do

not need to take it with food

3

easier

to adjust the dose up or down as you need

LDN has been magical for me, just persist & be

patient & your husband will see it too BUT if he has MS with bad spasticity/pain

LDN can exacerbate these, as happened to me. Pain & spasticity were

my primary & most consistent symptoms since my first attack at 15 years old.

What does your husband take for the spasms – Dr Bob Lawrence is very

against baclofen (I was never offered anything else & now I have pump…)

& says he personally has success with gabapentian. You can contact him by

email & he replied to me really quickly.

All the best

Trish

From: low dose naltrexone

[mailto:low dose naltrexone ]

On Behalf Of dejavudo_99

Sent: Thursday, 21 October 2010 10:59 AM

low dose naltrexone

Subject: [low dose naltrexone] new to ldn...advice needed

Hi all,

My husband has SPMS, diagnosed 2001. He's been on ldn for just over 2 weeks

now. He's taking 1.5mg nightly in capsule form. He's has no vivid dreams or

restless nights but has had his MS symptoms ramp up considerably..ie...pain,

spasms and fatigue. I've read many of the posts on here and as much as I can

find online and I see where this is happening, but usually only lasting 7-10

days until the body adjusts. My question is, has anyone had a similar

experience and if so about how long should he expect to feel so crappy? I know

everyone reacts differently, but some guidance would be much appreciated!!

Thanks,

Sue