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I read the post by H and I read this reply to the article and it sums up what I feel.First, the contradiction between LDN’s supposed ability to assist with conditions that benefit both from immune stimulation as well as those auto-immune conditions that wouldn’t benefit from stimulation of that kind. In The Promise of Low Dose Naltrexone Therapy,http://www.amazon.com/Promise-Low-Dose-Naltrexone-Therapy/dp/0786437154/ref=sr_1_1?ie=UTF8 & s=books & qid=1273068480 & sr=1-1the authors discuss the theory that LDN dampens overstimulation of the branch of the immune system responsible for auto-immune activity while

simultaneously increasing the functioning of the viral fighting branch by balancing the Th1-Th2 system. If true, this could explain that contradiction.Second, LDN is available as an off-patent generic, rendering further investigation by pharmaceutical companies not cost-effective. I suspect a large part of the desperate hype surrounding LDN has to do with the fact that many early pilot studies, especially with regards to MS, have been promising enough that further research does seem warranted, yet our current system leaves little incentive for anyone to invest the enormous sums of money required to definitively answer the questions raised about it.As a CFIDS patient with documented low natural killer cell function, I made the choice to do a trial of LDN based on one of those pilot studies that showed an increase in NKC function from LDN. I have not yet been on it long enough to see if it has increased my own NKC function, but it has unquestionably improved my mood, a valuable benefit when dealing with a currently incurable debilitating disease.I would certainly have preferred to have rigorous studies to back up that decision, but I question your belief that science will ever come given the lack of economic incentive involved. Given the minimal risk of side effects and the cheap price, it seems a not unreasonable

experiment for patients who have exhausted other options.Great response to the article I love what they said. There is no monetary incentive for studies, so, we are going to have to do this ourselves. I am encouraged by the Stanford study results and look forward to receiving my LDN this week. Science does not always have the answers or takes a long time to find them.

There are many natural remedies that Science does not have the answers as to why they work and they will not invest the money into studies of supplements they cannot patent. I have seen miracles... my grandson who has Autism is using QEEG an specialized form of bio feedback! He was not speaking, he was having serious GI problems and was on 3 medications. After three QEEG treatments he started to speak... slowly, but three treatments! His GI problems disappeared and he was able to get off the meds he had been on for over a year. There are no studies proving why it works but it did and now he is getting more treatments and we cannot believe the difference in his sensory disorder issues. My point, I am not going to wait for "science " to catch up.... we need treatments now and I have seen enough people getting good results from LDN, to be ready to be a pioneer and add my story to this journey! "Courage does not always roar. Sometimes, it is the quiet voice at the end of the day saying, "I will try again tomorrow"."