Guest guest Posted May 14, 2010 Report Share Posted May 14, 2010 Again came only to me but meant for the group I believe. ---------- Forwarded message ----------From: carcinoidwarrior <carcinoidwarrior@...> Date: Thu, May 13, 2010 at 5:30 PMSubject: Re: Fwd: [low dose naltrexone] Re: mixing ldnjaxi <jaxi.schulz@...> " You do NOT have to crush the tab, I used to cut mine in half but I don't even know if that's necessary. watch it dissolve, shake the bottle while it's dissolving and then refrigerate it. when ready to use, DO NOT shake the bottle again. let the " dredges " settle at the bottom and don't mix them up again in the good solution. " Is the person you are referencing a pharmacist or scientist? If not why would we just accept this without evidence? Jackie From: jaxi <jaxi.schulz@...>Subject: Fwd: [low dose naltrexone] Re: mixing ldn " LDN LowDoseNaltrexone " <low dose naltrexone >Date: Thursday, May 13, 2010, 2:27 PM Came only to me ... meant for group I think. ---------- Forwarded message ----------From: Nuala White <nualawhite@...> Date: Tue, May 11, 2010 at 3:51 PMSubject: RE: [low dose naltrexone] Re: mixing ldnjaxi <jaxi.schulz@...> The 'stuff' at the bottom includes high level of ferrous oxide which can be a major problem for many. So it is importan tnot to shake. Nuala Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 14, 2010 Report Share Posted May 14, 2010 > > " You do NOT have to crush the tab, I used to cut mine in half but I don't >even know if that's necessary. watch it dissolve, shake the bottle while >it's dissolving and then refrigerate it. when ready to use, DO NOT >shake the bottle again. let the " dredges " settle at the bottom and don't >mix them up again in the good solution. " > >Is the person you are referencing a pharmacist or scientist? If not why >would we just accept this without evidence? > >Jackie The fact that the LDN stays in solution and doesn't settle out has been originally stated by a chemist (or two or three) on the list and validated by Dr Skip, the LDN pharmacist who recently had a heart incident (more prayers said for Dr Skip). Some people have expressed concern about the iron content of the sediment for people whose conditions require the avoidance of iron intake. Dr Skip has said that he thinks concerns about the sediment are overblown, but that yes in fact the LDN remains in solution. -- ~~~ There is no way to peace; peace is the way ~~~~ --A.J. Muste Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2010 Report Share Posted May 15, 2010 ,I don't believe that it is a fact that the NTX remains in solution. In compounder prepared LDN liquids, a viscous additive is what suspends the NTX evenly throughout the liquid.In home made LDN solution the NTX powder dissolves, yes, but that does not mean the NTX is evenly distributed in the liquid. Thus the bottle must be shaken.Art posted this commentary with a note from Skip attached at the bottom. It should putthis fuffle to rest I believe. Jackie"How long does liquid LDN last?http://preview.tinyurl.com/lvnhnfHere is what Larry Frieders the pharmacist had to say:STABILITY OF NALTREXONE From: "Larry J. Frieders" <larry@t...>Date: Wed Mar 3, 2004 5:44 pmSubject:NOT 1 day... NOT 1 week...BUT a MONTH or MORE! Naltrexoneis quite stable in water. I am quoting from Trissel's book, "Stability ofCompounded Formulations", Second Edition, page 266 "Stability-indicating HPLCanalysis found less than 10% loss within 90 days at either 4 degrees C or 25degrees C; most samples exhibited no loss. .... The recommended shelf lives of30 and 60 days stored at 25 degrees C and 4 degrees C, respectively." This is areference book that every compounder OUGHT to have on hand. 4 degrees C isrefrigeration and 25 degrees C is room temperature. We make a lotof naltrexone solutions for people who need to adjust their doses.The most popular strength is 1mg per ml. We supply a syringe withwhich the patient can measure the correct dose. It is bitter so itneeds to be mixed with something (unless you have strong tastebuds). Nobody has ever complained that it "stopped working".Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora,IL 60506 630-859-0333 FAX 630-859-0114What Larry has left out is that this is a compounded LDN, not home made. Bigdifference.Dr.SkipOnce a drug passes from a solid to a liquid state, its shelf life can decreasedramatically.Therefore, do not make more than 50 ml of liquid Naltrexone at atime, store it in the refrigerator, and do not keep it for more than a month.The fresher the preparation, the better. Be sure to shake the liquid LDN wellbefore using, and keep it from direct exposure to sunlight."----- On Fri, 5/14/10, Baker <vbaker@...> wrote:From: Baker <vbaker@...>Subject: Re: Fwd: Fwd: [low dose naltrexone] Re: mixing ldn"LDN LowDoseNaltrexone" <low dose naltrexone >Date: Friday, May 14, 2010, 5:17 PM>>"You do NOT have to crush the tab, I used to cut mine in half but I don't >even know if that's necessary. watch it dissolve, shake the bottle while >it's dissolving and then refrigerate it. when ready to use, DO NOT >shake the bottle again. let the "dredges" settle at the bottom and don't >mix them up again in the good solution.">>Is the person you are referencing a pharmacist or scientist? If not why >would we just accept this without evidence?>>JackieThe fact that the LDN stays in solution and doesn't settle out has been originally stated by a chemist (or two or three) on the list and validated by Dr Skip, the LDN pharmacist who recently had a heart incident (more prayers said for Dr Skip). Some people have expressed concern about the iron content of the sediment for people whose conditions require the avoidance of iron intake.Dr Skip has said that he thinks concerns about the sediment are overblown, but that yes in fact the LDN remains in solution.-- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2010 Report Share Posted May 15, 2010 There is no way that the liquid is not mixed completely, try it with salt. If the product is soluble in water it is thoroughly mixed. Shake it if you like although I do not need the iron.Naltrexone hydrochloride is a white, crystalline compound. The hydrochloride salt is soluble in water to the extent of about 100 mg/mL. NaltrexoneHydrochloride Tablets USP for oral administration are available as film coated tablets, containing 50 mg of Naltrexone hydrochloride.In addition, each tablet contains the following inactive ingredients: crospovidone, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, silicon dioxide, titanium dioxide, yellow iron oxide and red iron oxide.Read more: http://www.drugs.com/pro/naltrexone.html#ixzz0np0NuBgM--- On Fri, 5/14/10, carcinoidwarrior <carcinoidwarrior@...> wrote:From: carcinoidwarrior <carcinoidwarrior@...>Subject: Re: Fwd: Fwd: [low dose naltrexone] Re: mixing ldnlow dose naltrexone Date: Friday, May 14, 2010, 4:33 PM ,I don't believe that it is a fact that the NTX remains in solution. In compounder prepared LDN liquids, a viscous additive is what suspends the NTX evenly throughout the liquid.In home made LDN solution the NTX powder dissolves, yes, but that does not mean the NTX is evenly distributed in the liquid. Thus the bottle must be shaken.Art posted this commentary with a note from Skip attached at the bottom. It should putthis fuffle to rest I believe. Jackie"How long does liquid LDN last?http://preview. tinyurl.com/ lvnhnfHere is what Larry Frieders the pharmacist had to say:STABILITY OF NALTREXONE From: "Larry J. Frieders" <larry@t...>Date: Wed Mar 3, 2004 5:44 pmSubject:NOT 1 day... NOT 1 week...BUT a MONTH or MORE! Naltrexoneis quite stable in water. I am quoting from Trissel's book, "Stability ofCompounded Formulations" , Second Edition, page 266 "Stability-indicati ng HPLCanalysis found less than 10% loss within 90 days at either 4 degrees C or 25degrees C; most samples exhibited no loss. .... The recommended shelf lives of30 and 60 days stored at 25 degrees C and 4 degrees C, respectively. " This is areference book that every compounder OUGHT to have on hand. 4 degrees C isrefrigeration and 25 degrees C is room temperature. We make a lotof naltrexone solutions for people who need to adjust their doses.The most popular strength is 1mg per ml. We supply a syringe withwhich the patient can measure the correct dose. It is bitter so itneeds to be mixed with something (unless you have strong tastebuds). Nobody has ever complained that it "stopped working".Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora,IL 60506 630-859-0333 FAX 630-859-0114What Larry has left out is that this is a compounded LDN, not home made. Bigdifference.Dr.SkipOnce a drug passes from a solid to a liquid state, its shelf life can decreasedramatically. Therefore, do not make more than 50 ml of liquid Naltrexone at atime, store it in the refrigerator, and do not keep it for more than a month.The fresher the preparation, the better. Be sure to shake the liquid LDN wellbefore using, and keep it from direct exposure to sunlight."----- On Fri, 5/14/10, Baker <vbakersstar (DOT) com> wrote:From: Baker <vbakersstar (DOT) com>Subject: Re: Fwd: Fwd: [low dose naltrexone] Re: mixing ldn"LDN LowDoseNaltrexone" <low dose naltrexone>Date: Friday, May 14, 2010, 5:17 PM>>"You do NOT have to crush the tab, I used to cut mine in half but I don't >even know if that's necessary. watch it dissolve, shake the bottle while >it's dissolving and then refrigerate it. when ready to use, DO NOT >shake the bottle again. let the "dredges" settle at the bottom and don't >mix them up again in the good solution.">>Is the person you are referencing a pharmacist or scientist? If not why >would we just accept this without evidence?>>JackieThe fact that the LDN stays in solution and doesn't settle out has been originally stated by a chemist (or two or three) on the list and validated by Dr Skip, the LDN pharmacist who recently had a heart incident (more prayers said for Dr Skip). Some people have expressed concern about the iron content of the sediment for people whose conditions require the avoidance of iron intake.Dr Skip has said that he thinks concerns about the sediment are overblown, but that yes in fact the LDN remains in solution.-- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2010 Report Share Posted May 15, 2010 What occurs if you have a drink of alcohol while on naltrexone 4.5 mg.. Apparently you are not suppose to have any alcohol. ? does it inactivate the drug or just make you feel badly. ? mpbo4@..., Malcolm B. __________ Information from ESET NOD32 Antivirus, version of virus signature database 5115 (20100514) __________The message was checked by ESET NOD32 Antivirus.http://www.eset.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2010 Report Share Posted May 15, 2010 My LDN tabs are 3mg as ive just started on them and all it says on the label each containg naltraxone hydrochloride (Dilutent: Lactose) they are in capsule form, is this okay? Mark From: "bicyclenutmail-ldn@..." <bicyclenutmail-ldn@...>low dose naltrexone Sent: Sat, May 15, 2010 3:43:29 AMSubject: Fw: Re: Fwd: Fwd: [low dose naltrexone] Re: mixing ldn There is no way that the liquid is not mixed completely, try it with salt. If the product is soluble in water it is thoroughly mixed. Shake it if you like although I do not need the iron. Naltrexone hydrochloride is a white, crystalline compound. The hydrochloride salt is soluble in water to the extent of about 100 mg/mL. NaltrexoneHydrochloride Tablets USP for oral administration are available as film coated tablets, containing 50 mg of Naltrexone hydrochloride.In addition, each tablet contains the following inactive ingredients: crospovidone, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, silicon dioxide, titanium dioxide, yellow iron oxide and red iron oxide.Read more: http://www.drugs. com/pro/naltrexo ne.html#ixzz0np0 NuBgM From: Baker <vbakersstar (DOT) com>Subject: Re: Fwd: Fwd: [low dose naltrexone] Re: mixing ldn"LDN LowDoseNaltrexone" <low dose naltrexone>Date: Friday, May 14, 2010, 5:17 PM >>"You do NOT have to crush the tab, I used to cut mine in half but I don't >even know if that's necessary. watch it dissolve, shake the bottle while >it's dissolving and then refrigerate it. when ready to use, DO NOT >shake the bottle again. let the "dredges" settle at the bottom and don't >mix them up again in the good solution.">>Is the person you are referencing a pharmacist or scientist? If not why >would we just accept this without evidence?>>JackieThe fact that the LDN stays in solution and doesn't settle out has been originally stated by a chemist (or two or three) on the list and validated by Dr Skip, the LDN pharmacist who recently had a heart incident (more prayers said for Dr Skip). Some people have expressed concern about the iron content of the sediment for people whose conditions require the avoidance of iron intake.Dr Skip has said that he thinks concerns about the sediment are overblown, but that yes in fact the LDN remains in solution.-- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2010 Report Share Posted May 15, 2010 Drinking and LDN This is exaclty the point. Its interesting how things get filitered but here is the story: Last year the day before I went to Scotland for the conference, I got a call from a lady that: 1. doesn't usually drink much ie a couple glasses of wine a week. 2. started on ldn, stopped alcohol. 3 2 months later, at 4.5mg, had a glass of wine and had projectile vomiting. don't care what the " books " say, I am just reporting what I heard, directly from the lady. 4. went to scotland and sat around a table of the " big wigs " who were all drinking. I stepped back waiting for the show to begin. Nothing happened. 5. I am a licesned professional, what i say actually matters from a legal perspective, what I say matter from a moral point of view, don't drink. you might get really sick. for those of you who drink, that's YOUR call, but lets say that you tell some one that its ok, when its not, and that person gets sick, No sweat off your butt, but the person affected is not happy and YOU created that problem. so you want to drink fine, its your butt, but just because you think you Know something, doesn't mean its true. True for what I say, yes, but if you follow my advice you won't get sick. from Dr.Skip Lenz > > What occurs if you have a drink of alcohol while on naltrexone 4.5 mg.. > Apparently you are not suppose to have any alcohol. ? does it inactivate > the drug or just make you feel badly. ? mpbo4@..., Malcolm B. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 15, 2010 Report Share Posted May 15, 2010 From: art_ldn <rtee54@...>low dose naltrexone Sent: Sat, May 15, 2010 3:49:20 PMSubject: Fwd: Fwd: [low dose naltrexone] Re: mixing ldn Drinking and LDNThis is exaclty the point. Its interesting how things get filitered but here is the story: Last year the day before I went to Scotland for the conference, I got a call from a lady that:1. doesn't usually drink much ie a couple glasses of wine a week.2. started on ldn, stopped alcohol.3 2 months later, at 4.5mg, had a glass of wine and had projectile vomiting. don't care what the "books" say, I am just reporting what I heard, directly from the lady.4. went to scotland and sat around a table of the "big wigs" who were all drinking. I stepped back waiting for the show to begin. Nothing happened.5. I am a licesned professional, what i say actually matters from a legal perspective, what I say matter from a moral point of view, don't drink. you might get really sick. for those of you who drink, that's YOUR call, but lets say that you tell some one that its ok, when its not, and that person gets sick, No sweat off your butt, but the person affected is not happy and YOU created that problem. so you want to drink fine, its your butt, but just because you think you Know something, doesn't mean its true. True for what I say, yes, but if you follow my advice you won't get sick. from Dr.Skip Lenz>> What occurs if you have a drink of alcohol while on naltrexone 4.5 mg..> Apparently you are not suppose to have any alcohol. ? does it inactivate> the drug or just make you feel badly. ? mpbo4@..., Malcolm B.>Shouldnt the pharmacys be telling the people that get there ldn this as its very important to note side effects like all medications do. mine never came with an information leaflet about any side effects or any info what so ever S Quote Link to comment Share on other sites More sharing options...
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