Re: LDN for Urinary Incontinence

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Tina,I learned about "Prokarin" on this group forum recently as a treatment for the symptoms of

Multiple Sclerosis. Prokarin was developed by a nurse after she

was diagnosed with MS. In researching possible treatments, she came across an old study that involved injecting histamine into MS patients.

This nurse eventually ended up with a transdermal (attached to the skin) patch that she named Prokarin and has histamine and caffeine in

it.I did some research and found out that Prokarin is available

but very expensive to use. I also found out that you can make your own

sublingual (under the tongue) drops with histamine powder that your doctor can prescribe for you. Or, you can have a compounding pharmacy make

the drops for you, which is what I

decided to do. (Of course, your doctor still has to prescribe the drops.) The drops do not have caffeine in them like the patch. I don't

tolerate caffeine well, so that's fine with me. I paid just under $45 for 1 fluid ounce. I've been using 2 drops at a time, 2-3 times in a 24

hour period.Apparently, histamine is a neurotransmitter aside from being what your body produces as a result of being exposed to an allergen. I worried that histamine could cause a severe allergic reaction, like anaphalactic shock. Before I started the treatment, I called the compounding pharmacist who told me that histamine does not cause anaphalaxis. Apparently, a different mechanism causes that. At most, he said that I might get itchy eyes or a runny nose. The first drop I took caused my

eyes to burn. Since then I haven't even experienced that. If you have

asthma you can have complications.

Some people develop a rash at the site of the skin patch.I am attaching links to just 2 of the websites I read before asking my neurologist for a prescription.Carolynhttp://www.beyondwisdom.org/?p=17http://goodshape.net/From:

tina waite <waitetina@...>Carolyn Sell <cvaughansell@...>Sent:

Mon, May 10, 2010 9:19:06

AMSubject: Re:

[low dose naltrexone] Re: LDN & Urinary Incontinence

hi carolyn , Can you tell me what kind of drops you are talking about what is in there? thanks tinaOn Sat, May 8, 2010 at 1:10 PM, Carolyn Sell <cvaughansell@...>

wrote:

Malcolm,I take LDN for Primary Progressive Multiple Sclerosis. I can only tolerate 3mg

a night, though I should probably be on 4.5mgs. My spasticity is really bad, and I am not mobile. The 4.5mg dose makes me intolerably worse.

In any case, to answer your question, the LDN has not decreased my urinary incontinence (or any other symptom for that matter), or stopped the progression of my disease. However, one week ago I started taking sublingual histamine drops that my neurologist prescribed and a local compounding pharmacy made for me. So far, and not to be crass, I haven't had any "accidents" since I started the histamine! I pray that it is not a temporary effect and that the drops will work for me in other ways the longer I take it.

My

story shouldn't stop you from taking LDN and hoping for the best. It obviously affects people in different ways and may work for you.Carolyn

From:

Malcolm Boghosian <mpbo4@...>

low dose naltrexone Sent: Thu, May 6, 2010 10:30:24 AM

Subject: [low dose naltrexone] endorphin blockade when feel best

Does anyone get relief from incontinence by the use

of Naltrexone

LDN 4.5 mg or do you have to take other drugs also? Malcolm