Re: Question for Skip or anyone else who might know

[Guest guest]

Brown bottle???? I would ask the pharmacist about this.Sent from my BlackBerry device on the Wireless NetworkFrom: "waitinginbmt" <smithrp2000@...>Date: Tue, 20 Apr 2010 06:23:29 -0000<low dose naltrexone >Subject: [low dose naltrexone] Question for Skip or anyone else who might know If I dilute my 50 mg tablet in 50 ml of water in a brown bottle, how or why does it go bad? What is the mechanism or theory behind the idea that LDN goes bad? How long does it take to go bad? Thanks for any input.

[Guest guest]

Yes the bottle has to be brown i.e. you can’t see through

it, Not a clear bottle

www.ldndatabase.com

From: low dose naltrexone

[mailto:low dose naltrexone ] On Behalf Of caj229@...

Sent: 20 April 2010 10:24

waitinginbmt; low dose naltrexone

Subject: Re: [low dose naltrexone] Question for Skip or anyone else who

might know

Brown bottle???? I would ask the pharmacist about this.

Sent from my BlackBerry device on the Wireless Network

From: " waitinginbmt " <smithrp2000@...>

Date: Tue, 20 Apr 2010 06:23:29 -0000

<low dose naltrexone >

Subject: [low dose naltrexone] Question for Skip or

anyone else who might know

If I dilute my 50 mg tablet in 50 ml of water

in a brown bottle, how or why does it go bad? What is the mechanism or theory

behind the idea that LDN goes bad? How long does it take to go bad? Thanks for

any input.

[Guest guest]

And I guess that is given from the compound pharmacy, and do you know why it spoils, or doesn't it. I am yet to try LDN. Sent from my BlackBerry device on the Wireless NetworkFrom: " Donnelly" <john@...>Date: Tue, 20 Apr 2010 11:03:39 +0100<caj229@...>; 'waitinginbmt'<smithrp2000@...>; <low dose naltrexone >Subject: RE: [low dose naltrexone] Question for Skip or anyone else who might know Yes the bottle has to be brown i.e. you can’t see throughit, Not a clear bottle www.ldndatabase.com From: low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of caj229rogersSent: 20 April 2010 10:24waitinginbmt; low dose naltrexone Subject: Re: [low dose naltrexone] Question for Skip or anyone else whomight know Brown bottle???? I would ask the pharmacist about this.Sent from my BlackBerry device on the Wireless NetworkFrom: " waitinginbmt " <smithrp2000 >Date: Tue, 20 Apr 2010 06:23:29 -0000<low dose naltrexone >Subject: [low dose naltrexone] Question for Skip oranyone else who might know If I dilute my 50 mg tablet in 50 ml of waterin a brown bottle, how or why does it go bad? What is the mechanism or theorybehind the idea that LDN goes bad? How long does it take to go bad? Thanks forany input.

[Guest guest]

Or surely a clear glass bottle with a brown paper bag or similar over it?? Kept in the fridge. According to a pharmacist over here, they say discard after say 30 days but in his opinion it could last longer if stored properly....

Yes the bottle has to be brown i.e. you can’t see through it, Not a clear bottle

www.ldndatabase.com

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[Guest guest]

I have read the reason liquid LDN is refrigerated is because it loses its

potency over time, but Dr. Skip posted this a few weeks ago:

The non-preserved liquid is refrigerated to keep any bacterial or fungal growth.

You should get a new bottle just before you leave and don't open it until there.

Remember you must have a prescription bottle if you are leaving the US.

Dr.Skip

>

> If I dilute my 50 mg tablet in 50 ml of water in a brown bottle, how or why

does it go bad? What is the mechanism or theory behind the idea that LDN goes

bad? How long does it take to go bad? Thanks for any input.

>

[Guest guest]

How long does liquid LDN last?

http://preview.tinyurl.com/lvnhnf

Here is what Larry Frieders the pharmacist had to say:

STABILITY OF NALTREXONE From: " Larry J. Frieders " <larry@t...>

Date: Wed Mar 3, 2004 5:44 pmSubject:

NOT 1 day... NOT 1 week...BUT a MONTH or MORE! Naltrexone

is quite stable in water. I am quoting from Trissel's book, " Stability of

Compounded Formulations " , Second Edition, page 266 " Stability-indicating HPLC

analysis found less than 10% loss within 90 days at either 4 degrees C or 25

degrees C; most samples exhibited no loss. .... The recommended shelf lives of

30 and 60 days stored at 25 degrees C and 4 degrees C, respectively. " This is a

reference book that every compounder OUGHT to have on hand. 4 degrees C is

refrigeration and 25 degrees C is room temperature. We make a lot

of naltrexone solutions for people who need to adjust their doses.

The most popular strength is 1mg per ml. We supply a syringe with

which the patient can measure the correct dose. It is bitter so it

needs to be mixed with something (unless you have strong taste

buds). Nobody has ever complained that it " stopped working " .

Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora,

IL 60506 630-859-0333 FAX 630-859-0114

What Larry has left out is that this is a compounded LDN, not home made. Big

difference.

Dr.Skip

Once a drug passes from a solid to a liquid state, its shelf life can decrease

dramatically.Therefore, do not make more than 50 ml of liquid Naltrexone at a

time, store it in the refrigerator, and do not keep it for more than a month.

The fresher the preparation, the better. Be sure to shake the liquid LDN well

before using, and keep it from direct exposure to sunlight.

--

>

>  Any tablet contains active ingredient, actual medication, as well as

few inactives, which make tablet stable till expiration date, and help your body

to absorb it in right way.When you preparing solution from tablet of any

medication there are two potential problems. First you are altering medication

delivery system and ,by doing so,changing its stability. Nobody knows for sure

how long Naltrexone is stable in liquid form since no company tested it. So less

time you store it more chances it is potent. Second problem, solution, if stored

too long , or not handled properly, can get contaminated with bacteria. This is

why it is recommended to keep it in the fridge.

>