Lost message?

[Guest guest]

I posted this message nearly 2 days ago as a follow up to a previous one but it

hasn't appeared yet - perhaps it got lost somehow.

Here it is again:

I've been on LDN for over 2 months now, for ME and FM. I had huge problems at

the start (see my first message below), which are sadly continuing.

I managed to increase the dose to 1 mg and then 1.5 mg after having a couple of

breaks of a few days, but now after a continuous spell of 10 days on 1.5 mg I

feel so ill I can hardly eat or walk. The pain is like nothing I've ever

experienced before - a severe cramp-like pain all over my body and I'm so dizzy

I stagger even with just a few steps. I'm losing weight fast, have intermittent

diarrhea, am shivering and sweating and have been almost completely bed-bound

for 4 weeks.

I still have the questions about TH1 and TH2 immunity - Art suggested I email Dr

McCandless with these, but I got no reply.

Has anyone any suggestions? Should I reduce the dose again, stop completely for

a while, or try to carry on. Has anyone else had these problems?

>

> Hi all

>

> Could anyone help me understand the theory behind how LDN works please? I've

read quite a lot of material, but am puzzled by something in a paper by Brown

and Pankkrepp - LDN for disease prevention and quality of life, published in

Medical Hypotheses, 2009.

>

> They cite research that suggests that beta-endorphins suppress TH1 and augment

TH2 cells. But other work suggests the opposite, and surely most conditions that

people take LDN for involve a damaging shift to TH2 immunity.

>

> I started LDN two and a half weeks ago for ME and Fibromyalgia (which I've had

for 28 years), taking 1.1 mg at first, then 1.5 mg for a few days. After one

week my pain and flu-like symptoms had got so much worse I decreased to 0.5 mg.

After 10 days on this dose I'm still in extreme pain, feeling very ill, sweating

and shivering, and haven't been able to eat anything much for all this time. So

I'm stopping today for a few days at least.

>

> Are these extreme reactions common at such a low dose?

>

> Many thanks for your help.

>

>

>