I'm New Here - Trouble Metabolizing LDN? Can Someone Shed Some light Here?

[Guest guest]

Hi Folks,

I'm new here and have tried LDN again recently after having tried it for a while

about five years ago. When I took it back then it was in 3 mg. compounded

capsules initially and later in 4.5 mg. capsules. I remember having the expected

problems remaining asleep for the first week of taking it and then feeling very

well and benefitting from it immensely afterward.

That was THEN....this time I have tried twice to take it for up to five

consecutive nights each time but end up feeling very drowsy and depressed, more

and more, as the days progress. What I am doing differently this time is,

instead of having the capsules compounded for me I am getting the 50 mg. Revia

tablets and grinding them into a powder under a spoon and adding the powder to

fifty mls. of distilled water. I keep this solution in the fridge after having

given it a very good duration of shaking to mix it in quite well. I have been

dosing it out with a graduated eye dropper for accuracy and I began, like

before, starting off with 3 mg. (3 ml.) per night before bedtime, around 10 or

10:30 p.m. I shake the bottle well each time before each dose to make sure it

hasn't settled in the bottle, which might cause innacurate dosage amounts.

Because I did so well with LDN in the not-too-distant past it has seemed a

little mysterious that I can't seem, so far at least, to get the correct

response from it this time. The only two things that seem possible and logical

(for me) for the change in its action this time vs. last time are:

1) This time by dosing it in a liquid form it is being assimilated into my brain

more readily than if it were a capsule and could be leading me to experience an

effect similar to that of taking a larger dose...let's say 12 mg., for

argument's sake. The end result is that the endorphin blockade is continuing far

beyond the few hours it normally does and extending well into the following day,

even close to the following nighttime. This is one idea which seems possible but

I see here that others are also taking it this way, without any depression being

mentioned. (normally, I am not depressive or if I am am only slightly so)

2) The other possibility I considered is that I am now not metabolizing the drug

as well as I once did due to my detox pathways being less efficient than they

once were. I am not taking any grapefruit or grapefruit juice which might hinder

the phase one pathways but...it just occurred to me that I have been taking

grapefruit seed extract here and there...could this be causing the problem?

Could the GSE be slowing down my phase one liver detox pathways, leading the LDN

to stay in my system much longer than it would normally?? Or...could I have just

experienced a slowing of my detox pathways, independent of the GSE, and

therefore need to take the LDN at a much lower dose, such as some of you are

doing, like 0.5 mg/night, for instance?

Can someone shed some light here? I would greatly appreciate it if you could!

Many thanks, in advance,