Re: Self compounded vs prescription Ldn

[Guest guest]

I've only done the liquid solution that I make up so no comparisons, guess I believe I'm getting a pretty accurate amount in my dose, up or down a bit I feel doesn't make a diff. I'm still FINALLY on 2mg. I thought I read somewhere earlier on NOT to do slow release. I get my tabs here in the U.S. and no longer shake the bottle and eventually drain out the sediment.

[low dose naltrexone] Self compounded vs prescription Ldn

I used to order Naltima from All Day Chemist, and dissolve it in liquid myself.Now, I take a prescription from a compounding pharmacy.\My concern, when I was doing it myself in liquid form, the liquid did not containa consistent amount of LDN.For instance, I crush a 50 mg tablet of Naltima, dissove it in water, then take3mg in a syringe. I have no way of knowing if that 3mg of liquid contains a consistent 3mg of LDN.On a side note, I asked the compounding pharmacy to use rice flour, instead of Avricel.The issue of compounding for calcium carbonate my affect the rice flour, of this I am not sure. The compacting of the filler effects the release of LDN, possibly making it less effective.Does anyone know the best filler to use when have LDN compounded.PS. I already asked for it to be slow releasing.

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[Guest guest]

Slow release?!! More bad advice from a newcomer.

LDN _MUST_ release _FAST_ in order for it to be effective!

WARNING on filler, especially those with CANCER

http://ldn.proboards.com/index.cgi?board=forum & action=display & thread=87

LDN FILLERS

http://ldn.proboards.com/index.cgi?action=display & board=personal & thread=867 & page\

=1#5834

Art

--

>

> I used to order Naltima from All Day Chemist, and dissolve it in liquid

myself.

> Now, I take a prescription from a compounding pharmacy.\

>

> My concern, when I was doing it myself in liquid form, the liquid did not

contain

> a consistent amount of LDN.

>

> For instance, I crush a 50 mg tablet of Naltima, dissove it in water,  then

take

> 3mg in a syringe.  I have no way of knowing if that 3mg of liquid contains a

> consistent 3mg of LDN.

>

> On a side note, I asked the compounding pharmacy to use rice flour, instead of

Avricel.

> The issue of compounding for calcium carbonate my affect the rice flour, of

this I am not sure.  The compacting of the filler effects the release of LDN,

possibly making it less effective.

>

> Does anyone know the best filler to use when have LDN compounded.

>

> PS.  I already asked for it to be slow releasing.

>

>

>

>

>

> __________________________________________________________________

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[Guest guest]

hope you meant to say you asked for it to be FAST releasing?

someone claiming to be an analytical chemist on an LDN list recently said

the naltrexone from a tab dissolved in water stays mixed evenly in the water

while sediment that settles is worthless and to not shake the bottle when

dosing if you want to avoid the iron oxides in the tab filler.

compounding pharmacies don't always mix it up perfectly even. a dissolved

tab might actually be more even and consistent dosing than a compounded

capsule. whatever the filler, if it's pre-dissolved it's going to hit the

systems faster than if a cap has to be dissolved ... the differences might

be neglible, i dunno.

________________________________

From: low dose naltrexone

[mailto:low dose naltrexone ] On Behalf Of P

Sent: Thursday, January 28, 2010 4:37 PM

low dose naltrexone

Subject: [low dose naltrexone] Self compounded vs prescription Ldn

I used to order Naltima from All Day Chemist, and dissolve it in

liquid myself.

Now, I take a prescription from a compounding pharmacy.\

My concern, when I was doing it myself in liquid form, the liquid

did not contain

a consistent amount of LDN.

For instance, I crush a 50 mg tablet of Naltima, dissove it in

water, then take

3mg in a syringe. I have no way of knowing if that 3mg of liquid

contains a

consistent 3mg of LDN.

On a side note, I asked the compounding pharmacy to use rice flour,

instead of Avricel.

The issue of compounding for calcium carbonate my affect the rice

flour, of this I am not sure. The compacting of the filler effects the

release of LDN, possibly making it less effective.

Does anyone know the best filler to use when have LDN compounded.

PS. I already asked for it to be slow releasing.

________________________________

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[Guest guest]

>someone claiming to be an analytical chemist on an LDN list

>recently said the naltrexone from a tab dissolved in water stays

>mixed evenly in the water while sediment that settles is worthless

>and to not shake the bottle when dosing if you want to avoid the

>iron oxides in the tab filler.

That was me. And, yes- when dissolved in water, the naltrexone will be evenly

distributed. The same principle is used when compounded by a pharmacy, except

instead of being dissolved in liquid, naltrexone powder is added to another

powder, mixed, and encapsulated.

>compounding pharmacies don't always mix it up perfectly even. a

>dissolved tab might actually be more even and consistent dosing than

>a compounded capsule.

This would depend upon many factors, including the accuracy of the different

tools being used- the ability to measure *exactly* 50 mL of water, or to measure

out *exactly* 1.000 mL for dosing. I own a micropipettor that can measure down

to 0.001 mL of liquid with great accuracy, so when I dole out 1 mL, I get 1.000

mL. Moreover, I can check the accuracy of this instrument against a calibrated

balance to ensure it delivers the correct quantity of liquid. The droppers at

the pharmacy are not this good; they can be calibrated against a balance if one

has access; distilled water weighs 1 gram per milliliter; a 0.01 gram balance

gives about 2% accuracy once the uncertainty in the last digit is taken into

account.

I would encourage individuals to purchase their product through a comopunding

pharmacy that knows what they're doing, like Skip. For those that cannot afford

to go this route or cannot find a physician to prescribe them the medication

from a Western pharmacy and must go another route, then I suggest that the

solution be prepared as carefully as possible, and that it NOT be shaken before

use.

-AJ