Alcohol releases beta-endorphin: a mechanism for LDN interaction

[Guest guest]

I’m sorry, it may just be me dense mind, but can

someone translate what this means?

Much thanks!

[Guest guest]

It is another study that looks at extreme conditions (acute ethanol), and concludes.... "suggests this or that, and may do this or that".

Bottom line don't drink like a fish, if in doubt, don't drink at all.

Cheers! Hear that? That's my wine glass clinking with my husbands. LOL

I'm sorry, it may just be me dense mind, but can someone translate what thismeans?Much thanks!

Alcohol Clin Exp Res. 2009 Jun;33(6):1033-43. Epub 2009 Mar 19.Effect of acute ethanol administration on the release of opioidpeptides from the midbrain including the ventral tegmental area.Jarjour S, Bai L, Gianoulakis C.Department of Psychiatry, McGill University, Montréal, Québec, Canada.BACKGROUND: Experimental evidence suggests that ethanol alters theactivity of the endogenous opioid peptide systems in a dose and brain-region dependent manner. These alterations may influence the processesof ethanol reward and reinforcement. Thus, it was the objective ofthis study to investigate the response of the 3 major opioid peptidesystems (endorphins, enkephalins, and dynorphins) to acute ethanoladministration, at the level of the midbrain including the ventraltegmental area (midbrain/VTA), a region important for drug, includingethanol reinforcement. METHODS: Using the in vivo microdialysistechnique coupled with specific solid-phase radioimmunoassay for beta-endorphin, met-enkephalin, and dynorphin A(1-8,) changes in theextracellular concentration of theses peptides at the level ofmidbrain/VTA were determined at distinct time points following theadministration of 0.0 (saline), 0.8, 1.2, 1.6, 2.0, and 2.4 g ethanol/kg B.Wt. RESULTS: A biphasic effect of ethanol on beta-endorphinrelease was found, with low to medium (1.2, 1.6, and 2.0 g) but nothigh (2.4 g) doses of ethanol, inducing a significant increase in thedialysate content of beta-endorphin. A late increase in the dialysatecontent of dynorphin A(1-8) was observed in response to the 1.2 gethanol dose. However, none of the ethanol doses tested significantlyaltered the content of met-enkephalin in the dialysate. CONCLUSIONS:The present findings suggest that the ethanol-induced increase of beta-endorphin release at the level of midbrain/VTA may influence alcoholreinforcement.PMID: 19302084