Elevated liver enzymes...

[Guest guest]

Study of hepatotoxicity of naltrexone in the treatment of alcoholism.

Yen MH, Ko HC, Tang FI, Lu RB, Hong JS.

Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan.

Since a black box warning was issued by the Food and Drug Administration regarding the use of the opiate antagonist naltrexone (NTX), many clinicians have been concerned about current labeling of the potential hepatotoxicity risk of NTX in the treatment of opiate dependence and alcoholism. Despite many reports that demonstrated that the use of NTX did not cause elevation of liver enzymes, controversy concerning whether NTX is hepatotoxic continues. The current study monitored 74 alcoholic patients who received 25mg of NTX daily in the first week and then 50mg of NTX daily for the rest of the 12-week period. After the 12-week treatment, levels of the hepatic enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) did not show any elevation, except in one subject, and the results strongly support that NTX did not induce abnormalities in liver function tests or elevate the liver enzymes. Instead, a statistical significance of decreasing levels of ALT and AST in the liver was shown throughout the study. These findings provide further support that NTX is not hepatotoxic at the recommended daily dose and may be beneficial for patients with elevated liver enzymes.

PMID: 16839858 [PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/16839858

I was prescribed LDN by Dr. Berkson last year http://www.drberkson.com/ - he has had tremendous success with the use of LDN in his patients, many of whom have various forms of Hepatitis and other liver disorders, including cirrhosis. In our group, "Hepatitis Children and Cam Alternatives", all of the people who are on LDN have significant drops in their liver enzymes. We also have many more studies such as the one above on how LDN is beneficial to the liver.

Hepatitis_Children_and_CAM_Alternatives/

Cheers,

Nola http://nolahepper.blogspot.com/

In a message dated 1/25/2010 8:56:38 P.M. Central Standard Time, even1@... writes:

http://www.ldnscience.org/interviews/141-ldn-as-a-potential-treatment-for-multiple-sclerosis

Interview with Dr. Maira Gironi, Institute of Experimental Neurology (INSPE) and Department of Neurology, San Raffaele Scientific Institute, Milan, Italy

Topic: LDN As A Potential Treatment For Multiple Sclerosis

What side effects have your patients encountered?

Most side effects documented were mild and reversible (i.e. a moderate increase in spasticity, urinary infections or mild liver enzymes increase). Very few were severe such as epatic steatosis , or worsening disease.

[Guest guest]

http://www.ldnscience.org/interviews/141-ldn-as-a-potential-treatment-for-multiple-sclerosisInterview with Dr. Maira Gironi, Institute of Experimental Neurology (INSPE) and Department of Neurology, San Raffaele Scientific Institute, Milan, Italy

Topic: LDN As A Potential Treatment For Multiple Sclerosis

What side effects have your patients encountered?

Most side effects documented were mild and reversible (i.e. a

moderate increase in spasticity, urinary infections or mild liver

enzymes increase). Very few were severe such as epatic steatosis , or

worsening disease.