Hi I'm new here

[Guest guest]

Hi all

Could anyone help me understand the theory behind how LDN works please? I've

read quite a lot of material, but am puzzled by something in a paper by Brown

and Pankkrepp - LDN for disease prevention and quality of life, published in

Medical Hypotheses, 2009.

They cite research that suggests that beta-endorphins suppress TH1 and augment

TH2 cells. But other work suggests the opposite, and surely most conditions that

people take LDN for involve a damaging shift to TH2 immunity.

I started LDN two and a half weeks ago for ME and Fibromyalgia (which I've had

for 28 years), taking 1.1 mg at first, then 1.5 mg for a few days. After one

week my pain and flu-like symptoms had got so much worse I decreased to 0.5 mg.

After 10 days on this dose I'm still in extreme pain, feeling very ill, sweating

and shivering, and haven't been able to eat anything much for all this time. So

I'm stopping today for a few days at least.

Are these extreme reactions common at such a low dose?

Many thanks for your help.