6MP LDN anti-TNF

[Guest guest]

By way of introduction, we are dealing with Crohn's, psoriasis, arthritis and

chronic fatigue.

The following post is very informative. I am trying to find out a little more

about why 6mp is contraindicated with LDN. Jaco mentions that many people use

LDN with chemotherapy and since 6mp is primarily used for leukemia, I'm still

not sure how incompatible they are. Also, we added allopurinol to modulate the

metabolites and protect the liver.

I came across an excellent study showing that naltrexone is anti TNF-alpha as

well. This may be one of the reasons it is so effective. And it makes sense to

me that it would not be a good idea to be on other anti-tnf drugs like Humira at

the same time.

Greeneltch , K.M., Haudenschild, C.C., Keegan, A.D., Shi, Y. (2004) " The opioid

antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor necrosis

factor-agr production. " Brain Behav Immun. 18: 476-484

>

> > From: Cheryl <klingongal@...>

> > Subject: [low dose naltrexone] Narcotics information

> > low dose naltrexone

> > Date: Thursday, April 23, 2009, 6:38 PM

> > Hey all,

> >

> > I've seen a lot of posts about Soma and other medications

> > being listed as " narcotics " or mislabeled as

> > " benzodiazepines " , etc. Nothing personal, but being a

> > Certified Pharmacy technician, this drives me nuts!� So

> > I thought I'd post something about narcotics etc. and pass

> > along the information.

> >

> >

> > From a medical standpoint, narcotics are medications that

> > cause drowsiness and dulling of the senses and are usually

> > used in reference to opioids (morphine and other similar

> > drugs such as heroin). However, most law enforcement

> > officials (and most of the general public) use the word

> > " narcotic " to describe any addictive medication or illegal

> > substance, such as cocaine or marijuana, even if they are

> > actually stimulants.

> >

> > Opiates/Opioids are used mostly as pain relievers, or

> > Analgesics.�

> >

> > Some different classes and samples of Analgesics are:

> >

> > Antirheumatic Agents - Biologic Response Modifiers (Humira,

> > Enbrel, Remicade)

> >

> > Antirheumatic Agents - Disease Modifying (Imuran,

> > Plaquenil, Methotrexate)

> >

> > Muscle Relaxants

> > Baclofen

> > Carisoprodol (Soma)

> > Chlorzoxazone

> > Cyclobenzaprine

> > Dantroline

> > Metaxalone

> > Methocarbamol

> > Orphenadrine

> > Tizanidine

> >

> > Non-opiod analgesics - Aspirin, Tylenol, NSAIDs, Fioricet,

> > Soma, Ultram, COX2 inhibitors)

> >

> > Opioid Agonist-Antagonists - medications with partial

> > antagonistic action that still act like agonists

> > (Buprenorphine, Butophanol, Nalbuphine, Pentazocine)

> >

> > Opioid Agonists (These are the biggies)

> > Codeine

> > Fentanyl

> > Hydromorphone

> > Levorphanol

> > Meperidine

> > Methadone

> > Morphine

> > Oxycodone

> > Oxymorphone

> > Propoxyphene

> >

> > Opiod Antagonists (Naloxone, Naltrexone)

> >

> >

> > Now, there's an entirely different class of medications out

> > there as well called Anxiolytics/Hypnotics.� These are

> > the medications that can ease some muscle spasms, calm you

> > down, or put you to sleep.� They are sorted by how long

> > the effects stay in your body (half-life).� A half-life

> > means that the drug is reduced by half it's original

> > strength in the blood.� So, the longer the half-life,

> > the longer the medication stays in your system.

> >

> > Benzodiazepines - Long Half-Life (25-100 hours)

> > Chlordiazepoxide

> > Clonadepam

> > Clorazepate

> > epam

> > Flurazepam

> >

> > Benzodiazepines - Medium Half-Life (10-15 hours)

> > Estazolam

> > Lorazepam

> > Temazepam

> >

> > Benzodiazepines - Short Half-Life (<12 hours)

> > Alprazolam

> > Oxazepam

> > Triazolam

> >

> > Axiolytics/Hynotics - OTHER (not benzodiazepines)

> > Buspirone

> > Chloral Hydrate

> > Eszopiclone

> > Ramelteon

> > Zaleplon

> > Zolpidem

> > Zopiclone

> >

> >

> > So.� Muscle relaxers are NOT opiates/opioids.�

> > Xanax isn't an Opiate/Opioid.� They're in different

> > classes, different drugs.� Yes, some of the anxiolytics

> > can relieve pain, but that's not their intended purpose -

> > the original intention is to RELAX (mind or muscles) which

> > in turn has an effect on pain relief perception.

> >

> >

> > Now, according to information that I was sent, there are a

> > few other medications (other than opiate/opioids) that

> > should not be taken with LDN therapy, and just for the heck

> > of it I'll list them here:

> >

> > Pentazocine

> > Clonidine

> > Dronabinol, THC, Marijuana

> > Disulfuram

> > Nabilone

> > Thioridazine

> > Tramadol (because it binds to the opiate receptors)

> > Novantrone

> > Rebif

> > Avonex

> > Betaseron

> > Tysabri

> > Cellcept

> > Methotrexate

> > Chemotherapy medications

> > Remicade

> > 6MP

> > Humira

> >

> >

> > I hope this helps some of you understand a little better

> > how some of the drugs you take work in your system, and what

> > you can or cannot take with the LDN protocol.

> >

> > Cheryl

>