Re: 6MP LDN anti-TNF

[Guest guest]

> I came across an excellent study showing that naltrexone is anti TNF-alpha as

well. This may be one of the reasons it is so effective. And it makes sense to

me that it would not be a good idea to be on other anti-tnf drugs like Humira at

the same time.

>

>

> Greeneltch , K.M., Haudenschild, C.C., Keegan, A.D., Shi, Y. (2004) " The

opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor

necrosis factor-agr production. " Brain Behav Immun. 18: 476-484

That's interesting; I hadn't seen that study- thank you. I'll have to look that

up and see what dosage they were looking at, as it was probably (being from

2004) dealing with 50 mg dosing for management of addiction.

A little side-note: several supplements are anti-TNF as well, albeit very mild

ones. Others somehow seem to tip immunity in the favor of the host (versus the

disease). Specifically:

Vitamin D. Recommended: get your D tested. Aim for 50-60 nanograms/milliliter.

Barring that, supplement with 5000 IU/day for the first few weeks, and taper

down to 2000 IU/day. Doses of up to 10,000 IU/day are safe (Hathcock et al.,

2007).

Selenium: 100-200 micrograms/day (note: NOT milligrams, but MICROGRAMS). Reimund

et al. (2000) observed reduced levels of selenium in Crohn's patients, and

observes that TNF- & #945; levels were inversely related to selenium levels.

Zinc: Ibs and Rink, 2004, suggest that supplementation with 110 mg/day of zinc

sulfate improved the barrier function of the intestines, suppressed T-cells, and

improved thymus function in 8 weeks.

Lastly, fish oil and coconut oil. Fish oil undoubtedly helps from the added

vitamin D it provides, but it also supplies omega 3 fatty acids; the American

diet is relatively high in omega 6 (which are thought by some to be

pro-inflammatory), so skewing the ratio by adding more omega 3 fatty acids is

probably a good idea. Start with 1 capsule a day, build up to 3. Or just swill a

teaspoon of the stuff once or twice a day.

Similarly, coconut oil (1-3 tablespoons/day) has a beneficial effect on the gut.

Start low, work your way up as 3 tablespoons is a LOT of fat for those not used

to it, and may cause problems.

Note that dietary fats and proteins displace carbohydrates. Depending upon the

theory one chooses to believe, " starving " the " bad " bugs in the gut of their

sugars is a good idea. None of the organisms to which may of these gut maladies

have been ascribed can survive on fat and protein- which is probably what the

human gut has evolved to process. Stay away from grains.

Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G, Hollis BW,

Drezner MK. Low vitamin D status despite abundant sun exposure. J Clin

Endocrinol Metab. 2007 Jun;92(6):2130-5. Epub 2007 Apr 10.

Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J Clin

Nutr. 2007 Jan;85(1):6-18.

Ibs, KH, Rink, L. 2004. Zinc. In , A., Gail Darlington, and ne

Bendich. 2004. Diet and human immune function. Totowa, N.J.: Humana Press.

Monaco, MD. 2004. Osteoporosis, nutrition, and the immune system. In ,

A., Gail Darlington, and ne Bendich. 2004. Diet and human immune

function. Totowa, N.J.: Humana Press.

Pusztai A, Bardocz S. 1995. Lectins: Biomedical Perspectives. pp 155-182.

and Francis, London.

Reimund JM, Hirth C, Koehl C, Baumann R, Duclos B. Antioxidant and immune status

in active Crohn's disease. A possible relationship. Clin Nutr. 2000

Feb;19(1):43-8.

Sinclair HM. 1952. The diet of Canadian Indians and Eskimos. Proceedings of the

Nutrition Society, 12: 69-82 Cambridge University Press

[Guest guest]

Thanks ,

We've had a whirlwind month so I've just been reading the posts...

The immunologist recommended 1000 mg Vit D. so that's been added. " Flirting "

with the Specific Carbohydrate Diet for, say, 8 months now. Unfortunately,

very tough to maintain for a teenager! Your discussion about the role of fats

and oils on Candida is interesting. Favorite meal seams to be bacon and eggs so

checked cholesterol and is fine. Did not start Flagyl and dropped the Cipro

three weeks ago, and taking lots of probiotics (with HSOs) which has been VERY

helpful. 4 weeks on LDN, marked improvement in arthritis pain. Seems to have

picked up a virus (or two) and has been sick the last two weeks. Checked for

Strep and thrush, but okay so far--just taking a long time to recover (also went

out late too early and got sicker--again, attributed to " teenager " dilemma).

With being sick the last two weeks, just haven't been able to tell what effect

the LDN is having on the Crohn's much yet. But I do see more energy in spite of

the " flu " . I wondered if this flu is, perhaps, a kind of 'healing crisis'?

Still questioning 6mp issue, but anemia continues to improve and am reluctant to

'jump off that cliff'.

Barbara

>

> > I came across an excellent study showing that naltrexone is anti TNF-alpha

as well. This may be one of the reasons it is so effective. And it makes sense

to me that it would not be a good idea to be on other anti-tnf drugs like Humira

at the same time.

> >

> >

> > Greeneltch , K.M., Haudenschild, C.C., Keegan, A.D., Shi, Y. (2004) " The

opioid antagonist naltrexone blocks acute endotoxic shock by inhibiting tumor

necrosis factor-agr production. " Brain Behav Immun. 18: 476-484

>

> That's interesting; I hadn't seen that study- thank you. I'll have to look

that up and see what dosage they were looking at, as it was probably (being from

2004) dealing with 50 mg dosing for management of addiction.

>

> A little side-note: several supplements are anti-TNF as well, albeit very mild

ones. Others somehow seem to tip immunity in the favor of the host (versus the

disease). Specifically:

>

> Vitamin D. Recommended: get your D tested. Aim for 50-60 nanograms/milliliter.

Barring that, supplement with 5000 IU/day for the first few weeks, and taper

down to 2000 IU/day. Doses of up to 10,000 IU/day are safe (Hathcock et al.,

2007).

>

> Selenium: 100-200 micrograms/day (note: NOT milligrams, but MICROGRAMS).

Reimund et al. (2000) observed reduced levels of selenium in Crohn's patients,

and observes that TNF- & #945; levels were inversely related to selenium levels.

>

> Zinc: Ibs and Rink, 2004, suggest that supplementation with 110 mg/day of zinc

sulfate improved the barrier function of the intestines, suppressed T-cells, and

improved thymus function in 8 weeks.

>

> Lastly, fish oil and coconut oil. Fish oil undoubtedly helps from the added

vitamin D it provides, but it also supplies omega 3 fatty acids; the American

diet is relatively high in omega 6 (which are thought by some to be

pro-inflammatory), so skewing the ratio by adding more omega 3 fatty acids is

probably a good idea. Start with 1 capsule a day, build up to 3. Or just swill a

teaspoon of the stuff once or twice a day.

>

> Similarly, coconut oil (1-3 tablespoons/day) has a beneficial effect on the

gut. Start low, work your way up as 3 tablespoons is a LOT of fat for those not

used to it, and may cause problems.

>

> Note that dietary fats and proteins displace carbohydrates. Depending upon the

theory one chooses to believe, " starving " the " bad " bugs in the gut of their

sugars is a good idea. None of the organisms to which may of these gut maladies

have been ascribed can survive on fat and protein- which is probably what the

human gut has evolved to process. Stay away from grains.

>

>

> Binkley N, Novotny R, Krueger D, Kawahara T, Daida YG, Lensmeyer G, Hollis BW,

Drezner MK. Low vitamin D status despite abundant sun exposure. J Clin

Endocrinol Metab. 2007 Jun;92(6):2130-5. Epub 2007 Apr 10.

>

> Hathcock JN, Shao A, Vieth R, Heaney R. Risk assessment for vitamin D. Am J

Clin Nutr. 2007 Jan;85(1):6-18.

>

> Ibs, KH, Rink, L. 2004. Zinc. In , A., Gail Darlington, and

ne Bendich. 2004. Diet and human immune function. Totowa, N.J.: Humana

Press.

>

> Monaco, MD. 2004. Osteoporosis, nutrition, and the immune system. In ,

A., Gail Darlington, and ne Bendich. 2004. Diet and human immune

function. Totowa, N.J.: Humana Press.

>

> Pusztai A, Bardocz S. 1995. Lectins: Biomedical Perspectives. pp 155-182.

and Francis, London.

>

> Reimund JM, Hirth C, Koehl C, Baumann R, Duclos B. Antioxidant and immune

status in active Crohn's disease. A possible relationship. Clin Nutr. 2000

Feb;19(1):43-8.

>

> Sinclair HM. 1952. The diet of Canadian Indians and Eskimos. Proceedings of

the Nutrition Society, 12: 69-82 Cambridge University Press

>