Original Msg: Shaking LDN

[Guest guest]

For those wanting the information on where this post originated:

Here is the original message on not shaking posted Dec 29, 2009

2:55 pm. It is message #91300. Subject: Naltrexone and solutions

Garnet

For those of you that prepare naltrexone from 50 mg tablets dissolved in

water- I have a strong recommendation for you: do not shake the solution

before use. Shake when you prepare it, but once the tablet is dissolved,

there is no need to suspend the insoluble portions of the tablet.

This is fairly important for those with Crohn's, but possibly other

diseases as well. If the tablet contains iron oxide (the ones we buy

do), the iron is very hard on the system. Naltrexone is very soluble; it

will already be in the solution- it does NOT settle out. But removing

the iron oxide may help those with Crohn's.

I am an analytical chemist, and have discovered this by trial-and-error.

Iron supplementation is strongly discouraged for those on the SCD- and

there is a very good reason for that. The reason the body is

iron-deficient is because it believes it is combating an infection. If

the iron as supplements is withheld, one can consume iron-rich foods

like red meat, eggs, liver, etc. If the iron is added- particularly as

the iron oxide in naltrexone tablets- the result is pain and bleeding,

even in very small amounts.

Again- I'm a chemist by training. If you make your own solution, PLEASE

do not consume the insoluble sediment. There is absolutely no need to

shake the solution right before you consume it- only when you're

preparing it for the first time- as the naltrexone is already dissolved.

I hope this helps someone somewhere. Good luck, and best wishes.

[Guest guest]

I should make a few other notes explaining my rationale to those who care to

listen.

1) The naltrexone is dissolved, much in the same way as sugar may be dissolved

in a glass of water. Without using an ultracentrifuge, the sugar will not

" settle out, " as it is dissolved. Shaking does not distribute the naltrexone,

only the insoluble portions of the tablet. Shaking does no more to distribute

naltrexone evenly than shaking a can of soda causes the sweetener within to be

evenly distributed.

2) I am on a variation of the so-called " Specific Carbohydrate Diet. " The author

argues against iron supplementation in the form of encapsulated or tableted

iron, which is frequently an iron salt. For some reason, heme iron (iron in

blood, meat, and organs such as liver) is well-tolerated by those with Crohn's

and ulcerative colitis. OTOH, iron salts are very poorly tolerated, and this

goes back to potential disease origins.

A researcher in the UK has found increased antibodies to an organism called

Klebsiella pneumoniae for those with CD and UC. This is not unusual; colitis

patients have increased antibodies to a LOT of stuff. I will skip the evidence,

but if anyone want the Ebringer papers, I will send them. Anyway- klebsiella

" infections " (as well as those of the mycobacterium MAP, another organism that

is thought- by some- to cause colitis) are combated by the body hoarding iron.

On top of the bleeding, this is probably why so many colitis patients are

anemic; the body thinks it's fighting an infection. From Ratledge and Stanford

(1983):

" The pathogenic mycobacteria are among those organisms for which there is

compelling evidence that the availability of iron as a microbiological nutrient

plays a critical role in infection. Further, a normal host response to infection

is a depletion of iron availability with an increase in the amount of

unsaturated serum transferrin, which can render the serum bacteriostatic. This

property includes extracellular as well as intracellular growth of

mycobacteria. "

Similarly, from: http://emedicine.medscape.com/article/219907-overview

" Availability of iron increases host susceptibility to K pneumoniae infection.

Bacteria are able to compete effectively for iron bound to host proteins because

of the secretion of high-affinity, low molecular weight iron chelators known as

siderophores. This is necessary because most host iron is bound to intracellular

and extracellular proteins. In order to deprive bacteria of iron, the host also

secretes iron-binding proteins. "

Your doctors will not tell you this; they will simply tell you you're anemic

because of blood loss and, therefore, you need either a transfusion or more iron

pills. In all likelihood, the iron pills are contraindicated. Instead, one

should get their iron from food- liver, steak, eggs. Your body is intentionally

" hiding " this iron from what it perceives to be an infection, although this gets

complex as the klebsiells is not an infection in the true sense- it's a

commensal organism to which the body has formed a sensitivity to its waste

product, an enzyme called pullulanase.

For some reason, these bacteria don't feed well on heme iron- the iron found in

blood, eggs, liver, red meat, etc., but the human body can readily incorporate

them into its own heme iron. OTOH, these bacteria will do VERY well on iron

salts (iron oxide, iron sulfate, etc.), which is one reason why tableted iron

preparations seem to be contraindicated with Crohn's and ulcerative colitis.

3) My experience with ultra low dose naltrexone was that very tiny quantities of

shaken naltrexone solution prepared from tablets containing iron oxide caused

remarkable discomfort. When I stopped shaking the solution before removing my

daily dose, the discomfort stopped immediately.

I have very tight control over my condition, by which I mean on a daily basis, I

suffer no symptoms at all. My blood values have normalized, I'm back to my daily

routine- but the dose of naltrexone at the time was so low as to be negligible

(under 0.25 mg); my control over my condition predates my use of naltrexone, so

I do not attribute the drug to this status. But I can state with some authority

that if that tiny quantity of iron caused problems- by which I mean

sub-milligram doses of iron oxide- the iron that accompanies full doses (1.5 to

4.5 mg) would probably negate many of the positive effects of naltrexone.

From this, those of you that prepare your own naltrexone from tablets that

contain iron oxide should probably not shake your solution prior to

administration. I am willing to provide references from books and peer-reviewed

primary literature to back up these assertions that Kleb pneumo causes colitis;

just email me.

-AJ