Abx and Herbs for Biofilm

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Hi All,

The herbs that I have heard that are useful for biofilm include nattokinase,

serrapeptase and grapefruit seed extract.

I recently found a pubmed article about an effective abx treatment for biofilm.

I copied the abstract below:

An in vitro study of the susceptibility of mobile and cystic forms of Borrelia

burgdorferi to hydroxychloroquine.

Brorson O, Brorson SH.

Department of Microbiology, Vestfold Sentralsykehus, Tønsberg, Norway.

In this work the susceptibility of mobile and cystic forms of Borrelia

burgdorferi to hydroxychloroquine (HCQ) was studied. The minimal bactericidal

concentration (MBC) of HCQ against the mobile spirochetes was > 32 microg/ml at

37 degrees C, and > 128 microg/ml at 30 degrees C. Incubation with HCQ

significantly reduced the conversion of mobile spirochetes to cystic forms. When

incubated at 37 degrees C, the MBC for young biologically active cysts (1-day

old) was > 8 microg/ml, but it was > 32 microg/ml for old cysts (1-week old).

Acridine orange staining, dark-field microscopy and transmission electron

microscopy revealed that the contents of the cysts were partly degraded when the

concentration of HCQ was > or = MBC. At high concentrations of HCQ (256

microg/ml) about 95% of the cysts were ruptured. When the concentration of HCQ

was > or = MBC, core structures did not develop inside the cysts, and the amount

of RNA in these cysts decreased significantly. Spirochetal structures inside the

cysts dissolved in the presence of high concentrations of HCQ. When the

concentration of HCQ was > or = MBC, the core structures inside the cysts were

eliminated. These observations may be valuable in the treatment of resistant

infections caused by B. burgdorferi, and suggest that a combination of HCQ and a

macrolide antibiotic could eradicate both cystic and mobile forms of B.

burgdorferi.

PMID: 12102233 [PubMed - indexed for MEDLINE]