NEW RESEARCH - Bartonella infection: treatment and drug resistance

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Future Microbiol. 2010 Nov;5:1719-31.

Bartonella infection: treatment and drug resistance.

Biswas S, Rolain JM.

CNRS-IRD, UMR 6236, Unite de Recherche sur les Maladies Infectieuses et

Tropicales Emergentes (URMITE), Faculte de Medecine et de Pharmacie, Universite

de la Mediterranee, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France.

Bartonella species, which belong to the alpha-2 subgroup of Proteobacteria, are

fastidious Gram-negative bacteria that are highly adapted to their mammalian

host reservoirs. Bartonella species are responsible for different clinical

conditions affecting humans, including Carrion's disease, cat scratch disease,

trench fever, bacillary angiomatosis, endocarditis and peliosis hepatis. While

some of these diseases can resolve spontaneously without treatment, in other

cases, the disease is fatal without antibiotic treatment. In this article, we

discuss the antibiotic susceptibility patterns of Bartonella species, detected

using several methods. We also provide an overview of Bartonella infection in

humans and animals and discuss the antibiotic treatment recommendations for the

different infections, treatment failure and the molecular mechanism of

antibiotic resistance in these bacteria.

http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed & id=2113369\

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PMID: 21133691 [PubMed - in process]