BARTONELLA / VEGF food, herb, med LIST - (UPGRADED)

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LIST OF VEGF REDUCING HERBS, MINERALS, SUPPLEMENTS, BEVERAGES AND

PHARMACEUTICALS:

(last revised 12/14/10 - no new items added, expanded plant lists within

existing items)

*Avastin – " the chemo drug WORKS ON VEGF – if your tumor markers are expressing

a high VEGF ask your oncologist about Avastin even if it isn't regularly

prescribed for your type of cancer. VEGF levels can be checked by blood

work..... " – quoted from Roche (mfr. webpage)

*Allicin (garlic, Allium sativum) ICAM-1, FGF2, VEGF

[also listed - " Alliin " (sp – error ?) - INHIBITED VEGF SECRETION from human

fibrosarcoma cells.]

*AITC (Mustard essential oil - fungicidal and food preservative)- Exhibited

potent antiangiogenic activity associated with a SIGNIFICANT REDUCTION IN VEGF

EXPRESSION in a mice model bearing EAT cells.

*Apigenin (parsley, Petroselinum crispum) - INHIBITED EXPRESSION OF VEGF in

cancer cells associated with a significant inhibition in tumor angiogenesis.

*Bilberry.

*Caffeic acid (Coffee, and other caffeine containing foods) - SUPPRESSED VEGF,

inhibited vascularization and angiogenesis in mice bearing Caki-I human renal

carcinoma cell line.

*Capsaicin (chili pepper, Capsicum) - INHIBITED VEGF-induced p38 MAPK, p125

(FAK), and AKT activation, and capillary-like tube formation in human ECs.

*Chinese baical skullcap – 95% baicalin

*Chinese Wormwood –artemesia annua –95% artemisinin: Artemisiean (invasive plant

- world-wide) - REMARKABLY LOWERED VEGF EXPRESSION on tumor cells and KDR/flk-1

expression on endothelial cells as well as tumor cells.

*Curcumin (turmeric, Curcuma longa) - INHIBITED INDUCTION OF VEGF synthesis in

microvascular ECs through downregulation of NF-êB and AP-1 activity.

*Diallyl sulfide (an organosulfur compound found in plants of the genus Allium -

onions (A. cepa), shallots (A. oschaninii), leeks (A. ampeloprasum), scallions

(A. ascalonicum) and herbs such as garlic (A. sativum) and chives (A.

schoenoprasum).) - REDUCED SERUM LEVEL OF VEGF in B16-F10 melanoma bearing

C57BL/6 mice

*Dong quai, extract –hydroxyderricin ( sinensis - plant root)

*EGCG (Camellia sinensis - green tea) - INHIBITED VEGF PRODUCTION through

inhibition of ERK-1 and ERK-2 kinases in human colon cancer cells.

*Elderberry

*EPA(fish, usually salmon, oil)

*Flavopiridol(Dysoxylum binectariferum - India rainforest plant) - Inhibited

hypoxia-mediated HIF-1á expression, VEGF SECRETION, and tumor cell migration in

human U87MG and T98G glioma cell lines.

*Gambogic acid (gamboge tree, Garcinia hanburyi) - INHIBITED ACTIVATION OF

VEGFR2, c-Src, FAK, and AKT and angiogenesis in HUVEC and human prostate cancer

cells (PC3)

*Genistein (soybeans, Glycine max) - SUPPRESSED VEGF and FGF-2 expression;

inhibited tyrosine kinase and activation of NF-êB and AKT; inhibited

angiogenesis in renal cell carcinoma

*Gingerol (active constituent of fresh ginger) Inhibited VEGF-induced

capillary-like tube formation and sprouting in ECs in the rat aorta and new

blood vessel formation in the mouse cornea

*Ginkgo

*Grape Seed

*Luteolin (celery, thyme, dandelion, rinds, barks, leaves, clover blossom and

ragweed pollen, Salvia tomentosa, celery, green pepper, thyme, perilla,

chamomile tea, carrots, olive oil, peppermint, rosemary and oregano) - INHIBITED

VEGF induced survival and proliferation of HUVECs through PI3K/AKT-dependent

pathways

*Magnolia seed cones 90% honokiol

*Naringin (a flavanone glycoside - a major flavonoid in grapefruit, and found in

other citrus fruits) - " ...Naringin, followed by rutin, was the MOST POTENT

FLAVONOID INHIBITOR OF VEGF RELEASE, which causes angiogenesis, out of 21

flavonoids.... " (source: wiki)

*Perillyl alcohol (within essential oil of various botanicals including

lavender, peppermint, cherries, sage, and lemongrass) - DECREASED VEGF RELEASE

from cancer cells and stimulated the expression of Ang2 by ECs

*Phenolic-rich herbs (too numerous to mention)

*Propolis or CAPE - (resinous mixture that honey bees collect from tree buds,

sap flows, or other botanical sources)

*PSK or Coriolus orTrametes versicolor, also called Turkey Tail (asian polypore

muti-colored mushroom)

*Quercetin (parsley, Petroselinum crispum) - INHIBITED HYPOXIA-INDUCED VEGF

EXPRESSION in NCI-H157 cells through suppression of STAT-3 tyrosine

phosphorylation

*Resveratrol (Jananese knotweed, red grapes, Vitis vinifera) - BLOCKS VEGF- and

FGF-receptor-mediated angiogenic responses through inhibition of MAPK

phosphorylation in ECs

*Rosmarinic acid (lemon balm, rosemary, oregano, sage, thyme and peppermint) -

INHIBITED ANGIOGENESIS, VEGF EXPRESSION, and IL-8 release in ECs

*Rutin (a citrus flavonoid glycoside found in buckwheat, the leaves and petioles

of Rheum species, and asparagus. Rutin is also found in the fruit of the Fava

D'anta tree (from Brazil), fruits and flowers of pagoda tree, fruits and fruit

rinds (especially citrus fruits (orange, grapefruit, lemon, lime)) and berries

such as mulberry, ash tree fruits and cranberries. Its name comes from the name

of Ruta graveolens, a plant that also contains rutin. It is sometimes referred

to as Vitamin P, although not strictly a vitamin)

*Sanguinarine (bloodroot, Sanguinaria canadensis) - Exhibited antiangiogenic

activity through SUPPRESSION OF VEGF-induced proliferation and AKT activation in

EC

*Selenium

*Silibinin(milk thistle plant, Silybum marianum) - Exhibited antiangiogenic

activities against human CRC HT29 xenograft growth in mice associated with

DOWNREGULATION OF NOS, COX, HIF-1Á, AND VEGF EXPRESSION

*Taxol (Pacific yew, Taxus brevifolia) - INHIBITED VEGF production in human

leukemic cell lines

*ã-Tocotrienol (Palm, Nigella sativa) - Inhibited cobalt(II) chloride-induced

accumulation of HIF-1á and the paracrine SECRETION OF VEGF in human gastric

adenocarcinoma SGC-7901 cell line through downregulation of ERK-1/2 pathway

*Ursolic acid (apples, basil, bilberries, cranberries, elder flower, peppermint,

rosemary, lavender, oregano, thyme, hawthorn, prunes. Apple peels contain high

quantity)-Inhibited capillary formation, reduced SERUM LEVEL OF VEGF, NO, and

proinflammatory cytokines in C57BL/6 mice bearing B16-F10 melanoma cells)

*Vanillin(vanilla bean) - Suppressed HGF-induced tumor cell angiogenesis in a

mouse model through inhibition of PI3K/AKT signaling and VEGF EXPRESSION

SOURCES:

1.http://www.wpb-radon.com/pdf/Brodhead%20cancer%20recommendations.pdf

2.http://xa.yimg.com/kq/groups/23540717/1801748182/name/RegulationAngiogenesisNu\

triceuticals.pdf

3. http://www.ncbi.nlm.nih.gov/pubmed/19686817

4. http://www.mskcc.org/mskcc/html/58481.cfm#P

5. google and wikipedia - for specific plant lists of containing noted

constituents

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I CAUTION – A LOT MORE RESEARCH NEEDS TO BE DONE REGARDING THE ABOVE.

There are various mechanisms of VEGF upregulation and which occurs during

various conditions (most of the research involves tumors/cancer) which likely

does not apply to the mechanisms of Bartonella VEGF upregulation in every case.

Further VEGF itself appears complicated, as there are VEGF-1, VEGF-2, etc. - and

other factors which are complicated and which I do not claim to understand.

I THINK THE BEST THING ONE MIGHT TAKE FROM THE ABOVE LIST IS PROBABLY THAT AMONG

THOSE ITEMS WHICH ARE " COMMON FOODS, SPICES, and BEVERAGES, " THAT SOME OF THOSE

FOODS MAY BE MILDLY OR MODERATELY BENEFICIAL FOR INCLUSION IN ONE'S DIET (WHERE

CONTRAINDICTIONS DO NOT APPLY).

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