Guest guest Posted December 3, 2010 Report Share Posted December 3, 2010 Being new to the forum -I hope that my brand of research (of which I have piles to share) is agree-able: I am not sure how many people here who Bart. - have ever had their Bartonella virulence/treatment progress monitored via " Vascular Endothelial Growth Factor " (VEGF) testing? If one is to look at Buhner's book - specifically the detail regarding the up-regulation of VEGF by Bartonella (pg. 200)- it explains it pretty well. It's easy enough to find information regarding the reduction/down-regulation of VEGF. In addition to Bartonella upregulating it, VEGF is a normally occurring bio-chemical in the human body (with established clinical serum ranges) and which coincidently plays a key role being upregulated also in Cancer tumor growth. There is a treasure-trove of Cancer associated VEGF research (since Pharmaceutical companies foretell big profits in cancer drugs ~but unfortunately not for us!) - I decided a while ago that i'll take the damn information where-ever the hell I can get it ! Accordingly – since VEGF plays such a critical role in Bartonella's survival mechanisms and it's ability to colonize I've compiled the following (partial)list of foods, supplements, and pharmaceuticals, etc. which have all been clinically and/or scientifically supported to demonstrate the reduction of VEGF levels(albeit - during various circumstances and thru various mechanisms): LIST OF VEGF REDUCING HERBS, SUPPLEMENTS, AND PHARMACEUTICALS ------------------------------------------------------------- *Avastin – " the chemo drug WORKS ON VEGF – if your tumor markers are expressing a high VEGF ask your oncologist about Avastin even if it isn't regularly prescribed for your type of cancer. VEGF levels can be checked by blood work..... " – quoted from Roche (mfr. webpage) *Allicin (garlic, Allium sativum) ICAM-1, FGF2, VEGF [also listed -Alliin (sp – error ?) - INHIBITED VEGF SECRETION from human fibrosarcoma cells.] *AITC - Exhibited potent antiangiogenic activity associated with a SIGNIFICANT REDUCTION IN VEGF EXPRESSION in a mice model bearing EAT cells. *Apigenin (parsley, Petroselinum crispum) - INHIBITED EXPRESSION OF VEGF in cancer cells associated with a significant inhibition in tumor angiogenesis. *Bilberry. *Caffeic acid (Coffee) - SUPPRESSED VEGF, inhibited vascularization and angiogenesis in mice bearing Caki-I human renal carcinoma cell line. ( " Yeah COFFEE " !!! – my edit) *Capsaicin (chili pepper, Capsicum) - INHIBITED VEGF-induced p38 MAPK, p125(FAK), and AKT activation, and capillary-like tube formation in human ECs. *Chinese baical skullcap – 95% baicalin *Chinese Wormwood –artemesia annua –95% artemisinin: Artemisiean - REMARKABLY LOWERED VEGF EXPRESSION on tumor cells and KDR/flk-1 expression on endothelial cells as well as tumor cells. *Curcumin (turmeric, Curcuma longa) - INHIBITED INDUCTION OF VEGF synthesis in microvascular ECs through downregulation of NF-êB and AP-1 activity. *Diallyl sulfide - REDUCED SERUM LEVEL OF VEGF in B16-F10 melanoma bearing C57BL/6 mice *Dong quai, extract –hydroxyderricin *EGCG (green tea, Camellia sinensis) - INHIBITED VEGF PRODUCTION through inhibition of ERK-1 and ERK-2 kinases in human colon cancer cells. *Elderberry *EPA *Flavopiridol(Dysoxylum binectariferum) - Inhibited hypoxia-mediated HIF-1á expression, VEGF SECRETION, and tumor cell migration in human U87MG and T98G glioma cell lines. *Gambogic acid (gamboge tree, Garcinia hanburyi) - INHIBITED ACTIVATION OF VEGFR2, c-Src, FAK, and AKT and angiogenesis in HUVEC and human prostate cancer cells (PC3) *Genistein (soybeans, Glycine max) - SUPPRESSED VEGF and FGF-2 expression; inhibited tyrosine kinase and activation of NF-êB and AKT; inhibited angiogenesis in renal cell carcinoma *Gingerol Inhibited VEGF-induced capillary-like tube formation and sprouting in ECs in the rat aorta and new blood vessel formation in the mouse cornea *Ginkgo *Grape Seed *Luteolin - INHIBITED VEGF induced survival and proliferation of HUVECs through PI3K/AKT-dependent pathways *Magnolia seed cones 90% honokiol *Naringin - " ...Naringin, followed by rutin, was the MOST POTENT FLAVONOID INHIBITOR OF VEGF RELEASE, which causes angiogenesis, out of 21 flavonoids.... " (source: wiki) *Perillyl alcohol - DECREASED VEGF RELEASE from cancer cells and stimulated the expression of Ang2 by ECs *Phenolic-rich herbs *Propolis (CAPE) *PSK(Coriolus) *Quercetin (parsley, Petroselinum crispum) - INHIBITED HYPOXIA-INDUCED VEGF EXPRESSION in NCI-H157 cells through suppression of STAT-3 tyrosine phosphorylation *Resveratrol (Jananese knotweed, red grapes, Vitis vinifera) - BLOCKS VEGF- and FGF-receptor-mediated angiogenic responses through inhibition of MAPK phosphorylation in ECs *Rosmarinic acid - INHIBITED ANGIOGENESIS, VEGF EXPRESSION, and IL-8 release in ECs *Rutin (wiki) *Sanguinarine (bloodroot, Sanguinaria canadensis) - Exhibited antiangiogenic activity through SUPPRESSION OF VEGF-induced proliferation and AKT activation in EC *Selenium *Silibinin(milk thistle plant, Silybum marianum) - Exhibited antiangiogenic activities against human CRC HT29 xenograft growth in mice associated with DOWNREGULATION OF NOS, COX, HIF-1Á, AND VEGF EXPRESSION *Taxol (Pacific yew, Taxus brevifolia) - INHIBITED VEGF production in human leukemic cell lines *ã-Tocotrienol (Palm, Nigella sativa) - Inhibited cobalt(II) chloride-induced accumulation of HIF-1á and the paracrine SECRETION OF VEGF in human gastric adenocarcinoma SGC-7901 cell line through downregulation of ERK-1/2 pathway *Ursolic acid(rosemary, Rosmarinus officinalis)-Inhibited capillary formation,reduced SERUM LEVEL OF VEGF, NO, and proinflammatory cytokines in C57BL/6 mice bearing B16-F10 melanoma cells *Vanillin(vanilla bean) - Suppressed HGF-induced tumor cell angiogenesis in a mouse model through inhibition of PI3K/AKT signaling and VEGF EXPRESSION ------------------------------------------------------------------- I CAUTION – THAT A LOT MORE RESEARCH NEEDS TO BE DONE ON ALL OF THE ABOVE, BEFORE SOME WISE-GUY " ENTREPENEUR " GOES AND CREATES THE NEW " BARTONELLA WONDERDRUG " CONCOCTION TO MARKET TO ALL OF US BASED ON THE ABOVE LIST WHICH I SPENT HOURS PUTTING TOGETHER. – I think the best practical thing one can take from this list is that among those items which are listed above which are common foods,and spices, beverages, etc that these might be considered for inclusion in ones diet (they are " normal " edible spices, foods, and beverages). -------------------------------------------------------------------- SOURCES: 1.http://www.wpb-radon.com/pdf/Brodhead%20cancer%20recommendations.pdf 2.http://xa.yimg.com/kq/groups/23540717/1801748182/name/RegulationAngiogenesisNu\ \ triceuticals.pdf 3.http://en.wikipedia.org/wiki/Naringin FURTHER READING: This article may be about as detailed as it get's in describing the role of VEGF in Bartonella: http://edoc.unibas.ch/968/1/PhD_thesis_FS.pdf Another very recent (2009), and extremely technical article which evaluates and assesses a sort of the " state of the state " regarding Bartonella (compiled from various research sources) and which contemplates the " unanswered questions " and makes some " recommendations for future study " – surprisingly funded by the NIH and self-admitting from within it's title " persistence " . http://www.umanitoba.ca/faculties/medicine/units/medical_microbiology/courses/Mi\ \croPath97.705/PDF/Bartonella_ref2.pdf Further reading - VEGF: http://www.zellbiologie.uni-bonn.de/Haas/Publications/2005%20-%20CellMB%20-%20Ky\ \me.pdf Additional information regarding prescription Pharmaceutical VEGF inhibitors(cancer research): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711630/?tool=pubmed Quote Link to comment Share on other sites More sharing options...
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