ilads quotes and Questions

October 23, 2010

From ilads (Burrascano 10/2008) website: " If treatment is discontinued before

all symptoms of active infection have cleared, the patient will remain ill and

possibly relapse further. In general, early LB is treated for four to six weeks,

and late LB usually requires a minimum of four to six months of continuous

treatment. All patients respond differently and therapy must be individualized. "

He is shy of 8 weeks since tick removal. 1. Is he still considered " early " LB?

2. Is the re a timeline to break up stages?

" If high blood levels are not attained, treatment failures in early and late

disease are common. However, these high doses can be difficult to tolerate.

For example, doxycycline can be very effective but only if adequate blood levels

are achieved either by high oral doses (300 to 600 mg daily) or by parenteral

administration. Kill kinetics indicate that a large spike in blood and tissue

levels is more effective than sustained levels, which is why with doxycycline,

oral doses of 200 mg bid is more effective than 100 mg qid. Likewise, this is

why IV doses of 400 mg once a day is more effective than any oral regimen. "

3. So our son started doxycycline 100 mg BID yesterday as I have shared

preciously. Based on the above information, he should be on more possibly? He

told me today he had a bloody stool (diarrhea and he said a lot of blood). This

is the first time this has happened. He has had 2 doses of the antibiotics so

far + all herbs. I don't know what the cause of this is.

" Always check blood levels when using agents marked with an *, and adjust dose

to achieve a peak level above ten and a trough greater than three. Because of

this, the doses listed below may have to be raised. Consider Doxycycline first

in early Lyme due to concern for Ehrlichia co-infections.

*Doxycycline- Adults: 200 mg bid with food; doses of up to 600 mg daily are

often

needed, as doxycycline is only effective at high blood levels. Not for children

or in pregnancy. If levels are too low at tolerated doses, give parenterally or

change to another drug. "

4. Should my son be receiving blood tests?

LYME DISEASE REHABILITATION

" Despite antibiotic treatments, patients will NOT return to normal unless they

exercise, so therefore an aggressive rehab program is absolutely necessary. It

is a fact that a properly executed exercise program can actually go beyond the

antibiotics in helping to clear the symptoms and to maintain a remission. "

5. What are your thoughts on exercise and what has worked for you? I read the

physical therapy Rx Dr. B prescribed. We will follow that. WIth chronic

fatigue, I suppose I will get him to exercise on his good days?

October 24, 2010

Hi - I made a post on lymenet asking what is an appropriate level of

doxy. People have answered there. I think you need to go on lymenet and engage

with the Lyme patients there. They are very experienced at answering questions,

and everyone gives referrals to Lyme-experienced doctors.

You can go to www.lymenet.org and sign up. It's best not to use your full name

which could identify you too easily. Then you click on flash discussion and

medical questions. Either you can continue on the post I started in Medical

Questions, which is titled Doxy Question, or you are certainly welcome to start

your own post and I can delete the one I started. If you want Lyme-literate

doctor referrals in your area, which is my/our opinion that you need at this

point, you can ask in the section called Seeking A Doctor, and put your state in

the heading.

At least your son has you working hard for him, so thanks for asking us what to

do - Robin

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