Guest guest Posted September 1, 2006 Report Share Posted September 1, 2006 I have been interested in this topic for a while to. In summary L-Ornithine, L-arginine, tryptophan and certain antibiotics that lower ammonia producing gut bacteria (see below) it's a bit old there are probably newer articles Nelly Indian J Med Res. 1992 Oct;96:292-6. Related Articles, Links Effect of three antibacterial drugs in lowering blood & stool ammonia production in hepatic encephalopathy. T, K, Cherian AM, Kanakasabapathy. Department of Medicine, Christian Medical College, Vellore. Neomycin (700 mg/8 h), ampicillin (500/6 h) and metronidazole (400 mg/8 h), were compared for their effect, on oral administration for 4 days, in reducing blood ammonia in 27 patients with stable chronic liver disease. It was found that there was 38.2, 38.5 and 8.7 m mol/litre mean reduction in blood ammonia in the neomycin, ampicillin and metronidazole treated groups respectively. The difference in blood ammonia was statistically significant for both neomycin (P = 0.01) and ampicillin (P = 0.03) but there was no significant change after metronidazole treatment (P = 0.6). The total stool enzyme activity at optimum pH was maximally reduced by ampicillin and minimally with metronidazole. The reduction was noted to be 3.51 m mol/1 (P = 0.01), 3.87 m mol/1 (P = 0.08) and 2.8 m mol/1 (P = 0.02) of NH3/g dry weight of stool for neomycin, ampicillin and metronidazole respectively. The main bacterial gut enzymes responsible for ammonia production, urease and protease, were found to be very sensitive to stool pH. At pH 6 their activity was around 20 per cent of what was found in optimum pH of 7.4 and at pH 5 it is only about 8 per cent of optimum activity. None of the three antibacterial agents changed the stool pH significantly. It can be concluded that oral neomycin and ampicillin are superior to oral metronidazole in lowering blood ammonia. PMID: 1459672 [PubMed - indexed for MEDLINE] Brain Ammonia There are a number of causes of Ammonia in the Brain. There's Excessive exercise, Liver disease, Hepatic Encephalopathy, Radiation exposure, brain Infections, messed up Neurotransmitters, etc, etc, I thought these pages might interest listmembers. Katrina ---------- http://www.google.com/search?hl=en & ie=ISO-8859-1 & q=Brain+ammonia Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 1, 2006 Report Share Posted September 1, 2006 Hi Nelly, I'm wondering if anyone is taking Orthinine and with what results? Also, whether it is taken alone. L-Arginine...major precaution for those with herpes viruses. Tryptothan: A number of contraindications or precautions: Don't take with SSRIs, MAO Inhibitors, Tramdol, 5HTP, Cardidopa, Zolphem? or while pregnant. Possibly problems with history of cancer, possibly escalated risk of liver or brain toxicity, cataracts, fat consumption. I'll check the ABX, but looks like a couple of classes I cannot take. So, really hoping for Orthinine! (or the other one mentioned). BW, Katrina > > I have been interested in this topic for a while to. In summary L-Ornithine, L-arginine, tryptophan and certain antibiotics that lower ammonia producing gut bacteria (see below) it's a bit old there are probably newer articles > > Nelly > > Indian J Med Res. 1992 Oct;96:292-6. Related Articles, Links > > > Effect of three antibacterial drugs in lowering blood & stool ammonia production in hepatic encephalopathy. > > T, K, Cherian AM, Kanakasabapathy. > > Department of Medicine, Christian Medical College, Vellore. > > Neomycin (700 mg/8 h), ampicillin (500/6 h) and metronidazole (400 mg/8 h), were compared for their effect, on oral administration for 4 days, in reducing blood ammonia in 27 patients with stable chronic liver disease. It was found that there was 38.2, 38.5 and 8.7 m mol/litre mean reduction in blood ammonia in the neomycin, ampicillin and metronidazole treated groups respectively. The difference in blood ammonia was statistically significant for both neomycin (P = 0.01) and ampicillin (P = 0.03) but there was no significant change after metronidazole treatment (P = 0.6). The total stool enzyme activity at optimum pH was maximally reduced by ampicillin and minimally with metronidazole. The reduction was noted to be 3.51 m mol/1 (P = 0.01), 3.87 m mol/1 (P = 0.08) and 2.8 m mol/1 (P = 0.02) of NH3/g dry weight of stool for neomycin, ampicillin and metronidazole respectively. The main bacterial gut enzymes responsible for ammonia production, urease and protease, were found to be very sensitive to stool pH. At pH 6 their activity was around 20 per cent of what was found in optimum pH of 7.4 and at pH 5 it is only about 8 per cent of optimum activity. None of the three antibacterial agents changed the stool pH significantly. It can be concluded that oral neomycin and ampicillin are superior to oral metronidazole in lowering blood ammonia. > > PMID: 1459672 [PubMed - indexed for MEDLINE] > Brain Ammonia > > > > There are a number of causes of Ammonia in the Brain. There's Excessive > exercise, Liver disease, Hepatic Encephalopathy, Radiation exposure, > brain Infections, messed up Neurotransmitters, etc, etc, > > I thought these pages might interest listmembers. > > Katrina > > ---------- > > http://www.google.com/search?hl=en & ie=ISO-8859-1 & q=Brain+ammonia > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 11, 2010 Report Share Posted August 11, 2010 My daughter 4yrs and 8 months has high ammonia. She has massive brain fog, which seems to be related to ammonia and then yeast. How can we decrease ammonia in the brain? She has a very sensitive G.I. tract and cannot tolerate Alpha Ketoglutaric Acid, which showed high on her OAT as did taurine. Thank you Elena 5 rounds DMSA 6.25mg Quote Link to comment Share on other sites More sharing options...
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