Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 Thanks for the thoughtful input -  Kate  Yes to Pitocin and Epidural - On Thu, Nov 19, 2009 at 10:04 AM, J Acciarito <jacyone@...> wrote:   Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin.  Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the " info for doctors " on Respen-A's site: " " The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child. " The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT)    2a. Re: This is interesting!!!!!!!!!!!   Posted by: " pkuenstler@... " pkuenstler@...    Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K        A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG.     In addition to high serotonin levels, autistic children have a characteristically common " u " EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding.      However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to " normal " patterning. Starr says that behavioral improvement was also " evident " . " Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished, " Starr said.      The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood.      DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy.      However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism.     Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin.      DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to " shut off " early, stunting crucial neuro-development.      DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers.      MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. + Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 Thanks for the thoughtful input -  Kate  Yes to Pitocin and Epidural - On Thu, Nov 19, 2009 at 10:04 AM, J Acciarito <jacyone@...> wrote:   Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin.  Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the " info for doctors " on Respen-A's site: " " The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child. " The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT)    2a. Re: This is interesting!!!!!!!!!!!   Posted by: " pkuenstler@... " pkuenstler@...    Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K        A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG.     In addition to high serotonin levels, autistic children have a characteristically common " u " EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding.      However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to " normal " patterning. Starr says that behavioral improvement was also " evident " . " Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished, " Starr said.      The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood.      DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy.      However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism.     Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin.      DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to " shut off " early, stunting crucial neuro-development.      DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers.      MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. + Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 I also had Pitocin and Epidural. From: Kate Myers <katemyersny@...>autism Sent: Thu, November 19, 2009 10:08:56 AMSubject: Re: Respen-A Thanks for the thoughtful input - Kate Yes to Pitocin and Epidural - On Thu, Nov 19, 2009 at 10:04 AM, J Acciarito <jacyonecomcast (DOT) net> wrote:  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 I also had Pitocin and Epidural. From: Kate Myers <katemyersny@...>autism Sent: Thu, November 19, 2009 10:08:56 AMSubject: Re: Respen-A Thanks for the thoughtful input - Kate Yes to Pitocin and Epidural - On Thu, Nov 19, 2009 at 10:04 AM, J Acciarito <jacyonecomcast (DOT) net> wrote:  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 I had pitocin and a really bad reaction to it and then an epidural. My blood pressure dropped very low for a few minutes and they were pushing fluids. My son is on the mild end of the spectrum. Makes you wonder.  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 I had pitocin and a really bad reaction to it and then an epidural. My blood pressure dropped very low for a few minutes and they were pushing fluids. My son is on the mild end of the spectrum. Makes you wonder.  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 Thanks Judy for additional information. Pat K Respen-A  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting!!!!!!!!!!! Posted by: "pkuenstleraol" pkuenstleraol Date: Wed Nov 18, 2009 4:27 am ((PST)) Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. + Read more: is.gd/4WCX3 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 Thanks Judy for additional information. Pat K Respen-A  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting!!!!!!!!!!! Posted by: "pkuenstleraol" pkuenstleraol Date: Wed Nov 18, 2009 4:27 am ((PST)) Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. + Read more: is.gd/4WCX3 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 I also have fibromyalgia, which I have read is related to Pitocin. I never was sick until I had Pitocin. From: Rueter <susanr7r@...>autism Sent: Thu, November 19, 2009 3:40:08 PMSubject: Re: Respen-A I had pitocin and a really bad reaction to it and then an epidural. My blood pressure dropped very low for a few minutes and they were pushing fluids. My son is on the mild end of the spectrum. Makes you wonder.  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 I also have fibromyalgia, which I have read is related to Pitocin. I never was sick until I had Pitocin. From: Rueter <susanr7r@...>autism Sent: Thu, November 19, 2009 3:40:08 PMSubject: Re: Respen-A I had pitocin and a really bad reaction to it and then an epidural. My blood pressure dropped very low for a few minutes and they were pushing fluids. My son is on the mild end of the spectrum. Makes you wonder.  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 Hi All, I had the Pitocin drip with my oldest. She is 26 and very NT. She is also the one that had reactions to her DPT and MMR. I found out that the Pertussis part of the DPT is not " really " required here, so she only got the DT after that. She also had a Grand Mal seizure 22 hours after her MMR. Still she's VERY NT. I had a completely natural birth with . No pain meds no nothing. He had a 15 inch head at birth, and he's the one with Autism. My middle two, I had just pain meds with and they are VERY NT also. Go figure. > > Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. > > Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the " info for doctors " on Respen-A's site: > " " The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. > > So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child. " > > The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. > > I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. > > I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) > > I hope that everybody will continue to share any information they find about this treatment! > > Love, > Judy (mom to Jake, age 11, ASD, and , age 12, NT) > > > > 2a. Re: This is interesting!!!!!!!!!!! > Posted by: " pkuenstler@... " pkuenstler@... > Date: Wed Nov 18, 2009 4:27 am ((PST)) > > Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K > > > > A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. > In addition to high serotonin levels, autistic children have a characteristically common " u " EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. > However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to " normal " patterning. Starr says that behavioral improvement was also " evident " . " Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished, " Starr said. > The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. > DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. > However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. > Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. > DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to " shut off " early, stunting crucial neuro-development. > DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. > MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. > + Read more: is.gd/4WCX3 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 Hi All, I had the Pitocin drip with my oldest. She is 26 and very NT. She is also the one that had reactions to her DPT and MMR. I found out that the Pertussis part of the DPT is not " really " required here, so she only got the DT after that. She also had a Grand Mal seizure 22 hours after her MMR. Still she's VERY NT. I had a completely natural birth with . No pain meds no nothing. He had a 15 inch head at birth, and he's the one with Autism. My middle two, I had just pain meds with and they are VERY NT also. Go figure. > > Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. > > Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the " info for doctors " on Respen-A's site: > " " The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. > > So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child. " > > The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. > > I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. > > I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) > > I hope that everybody will continue to share any information they find about this treatment! > > Love, > Judy (mom to Jake, age 11, ASD, and , age 12, NT) > > > > 2a. Re: This is interesting!!!!!!!!!!! > Posted by: " pkuenstler@... " pkuenstler@... > Date: Wed Nov 18, 2009 4:27 am ((PST)) > > Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K > > > > A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. > In addition to high serotonin levels, autistic children have a characteristically common " u " EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. > However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to " normal " patterning. Starr says that behavioral improvement was also " evident " . " Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished, " Starr said. > The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. > DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. > However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. > Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. > DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to " shut off " early, stunting crucial neuro-development. > DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. > MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. > + Read more: is.gd/4WCX3 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 Hi Judy, My daughter was induced with petocin and had an epidural. Ethan's heartrate dropped dramatically enough that the nurses called the doctor in and he did a very forceful forceps delivery. I couldn't believe how hard he tugged on that baby to get him out. His precious little face was bruised for days after his birth. But I digress,lol,I was just addding another to the list of pitocin and epidural. She had an epi with Ethan's little sister but no pitocin and she is a perfectly typical little almost three year old. DebbieS > > Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. > > Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the " info for doctors " on Respen-A's site: > " " The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. > > So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child. " > > The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. > > I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. > > I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) > > I hope that everybody will continue to share any information they find about this treatment! > > Love, > Judy (mom to Jake, age 11, ASD, and , age 12, NT) > > > > 2a. Re: This is interesting!!!!!!!!!!! > Posted by: " pkuenstler@... " pkuenstler@... > Date: Wed Nov 18, 2009 4:27 am ((PST)) > > Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K > > > > A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. > In addition to high serotonin levels, autistic children have a characteristically common " u " EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. > However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to " normal " patterning. Starr says that behavioral improvement was also " evident " . " Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished, " Starr said. > The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. > DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. > However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. > Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. > DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to " shut off " early, stunting crucial neuro-development. > DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. > MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. > + Read more: is.gd/4WCX3 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 Hi Judy, My daughter was induced with petocin and had an epidural. Ethan's heartrate dropped dramatically enough that the nurses called the doctor in and he did a very forceful forceps delivery. I couldn't believe how hard he tugged on that baby to get him out. His precious little face was bruised for days after his birth. But I digress,lol,I was just addding another to the list of pitocin and epidural. She had an epi with Ethan's little sister but no pitocin and she is a perfectly typical little almost three year old. DebbieS > > Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. > > Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the " info for doctors " on Respen-A's site: > " " The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesia. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesia and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. > > So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child. " > > The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. > > I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. > > I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) > > I hope that everybody will continue to share any information they find about this treatment! > > Love, > Judy (mom to Jake, age 11, ASD, and , age 12, NT) > > > > 2a. Re: This is interesting!!!!!!!!!!! > Posted by: " pkuenstler@... " pkuenstler@... > Date: Wed Nov 18, 2009 4:27 am ((PST)) > > Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K > > > > A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. > In addition to high serotonin levels, autistic children have a characteristically common " u " EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. > However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to " normal " patterning. Starr says that behavioral improvement was also " evident " . " Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished, " Starr said. > The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. > DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med.net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. > However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. > Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. > DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to " shut off " early, stunting crucial neuro-development. > DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. > MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain. > + Read more: is.gd/4WCX3 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2009 Report Share Posted November 21, 2009 yes, good! From: Kate Myers <katemyersny@...>autism Sent: Thu, November 19, 2009 9:08:56 AMSubject: Re: Respen-A Thanks for the thoughtful input - Kate Yes to Pitocin and Epidural - On Thu, Nov 19, 2009 at 10:04 AM, J Acciarito <jacyonecomcast (DOT) net> wrote:  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 21, 2009 Report Share Posted November 21, 2009 yes, good! From: Kate Myers <katemyersny@...>autism Sent: Thu, November 19, 2009 9:08:56 AMSubject: Re: Respen-A Thanks for the thoughtful input - Kate Yes to Pitocin and Epidural - On Thu, Nov 19, 2009 at 10:04 AM, J Acciarito <jacyonecomcast (DOT) net> wrote:  Hi ladies! I just wanted to clarify that the contention presented in this article is not that epidurals cause autism, but that the drug pitocin does, specifically when given in conjunction with an epidural. Which almost always go hand-in-hand. Pitocin is often used to induce labor or to pick things up if labor isn't progressing as desired but the contractions caused by pitocin are harsher and more difficult to cope with than natural contractions. So you get an epidural, which then slows things down and/or makes it difficult to push properly so they give you more pitocin. Anyway, the drugs used in epidurals and pitocin are both/all processed by the same enzyme...oh nevermind, here; this is from the "info for doctors" on Respen-A's site: ""The Gale et al study reviewed birth records of Pitocin induction of labor, but not if women had received Pitocin augmentation following the administration of epidural anesthesia/analgesi a. It is common that contraction augmentation with Pitocin is often needed with epidurals. Also the Pitocin is continued often through the partuition stage because the mother often does not push effectively with epidural anesthesia/analgesi a and this is where the risk may lay. The cytochrome P-450 enzyme, cyp3A4, is increased during pregnancy and it is the enzyme that metabolizes Pitocin in the liver. This increased activitiy of the cyp3A4 during the pregnancy prevents contractions that could easily be triggered from the growing fetus. This enzyme is also in the placenta. The initiation of labor begins with a decrease in the cyp3A4 resulting in an increase in the oxytocin levels and contractions begin. The medications used in epidurals, bupivacaine and more recently ropivacaine, are metabolized by cyp3A4. These compete with Pitocin for the cyp3A4 enzyme and this can result in high levels of oxytocin, possibly high enough to trigger the negative feedback on the growth of the neurohypophysial system in the newborn. Ropivacaine has shown to be about 40% less potent than bupivacaine, but it has been promoted in the more recent years because it is the newer product to the market (1996). This can result in larger doses of the ropivacaine being needed, which can result in more competition for the cyp3A4 enzyme and higher Pitocin levels. If bupivacaine or ropivacaine are given with the analgesic, Fentanyl, then their effect is equal, but Fentanyl also is metabolized in the liver by cyp3A4. Another interesting fact is that females have more cyp3A4 than males do. This may also contribute to the increased rate of autism in boys. So these children that have been exposed to higher levels of oxytocin due to the epidural with Pitocin augmentation of contractions may have decreased oxytocin synthesis due to the premature growth cessation of the neurohypophysial system. Thus the infant/child may be at more risk for further insult on the endogenous oxytocin system by mercury exposure that inhibits oxytocin. Resulting in increased risk of autism in the child." The concept is fascinating and I'm anxious to see more research. I plan to ask Jake's psychiatrist about it at our next appt. to get his opinion. But I'm concerned because there is no good empirical evidence to support this theory yet. There have been no control studies, no double-blind trials, and there's no peer-reviewed literature. Like most parents of profoundly autistic children, I'm all for anything that may help my son or improve his quality of life. But not at the risk of harming him by giving him a homeopathic remedy that hasn't been sufficiently researched for safety let alone efficacy. I know that you, Pat, and the other regulars in this group are savvy enough by now to do your research and check things out carefully before trying them with your child(ren) but unfortunately not everybody does that and that is how autistic children end up harmed rather than helped by well-intentioned parents. I'm curious now though, how many of our kids were exposed to pitocin and/or epidurals during their birth? I had a scheduled c-section with Jake so epidural yes, but no pitocin, no opiates (which are also implicated here). Which excludes us from this theory. What's funny is that with my first son I had lots of pitocin (induced labor), not one but two epidurals (the first one came out during transition labor), pain-relief meds before finally agreeing to the epidural, and after 13 hours of labor I ended up with a c-section anyway because he was face-up and couldn't get through my small pelvis. And while he's kinda goofy, at age 12 he's an honor roll student, a brilliant violinist, clever and sensitive and intelligent. Not the first trace of autistic tendencies in him. In fact, I joke that started talking at 1 and hasn't stopped since. I have one child that won't talk and one that won't shut up. ;o) I hope that everybody will continue to share any information they find about this treatment! Love, Judy (mom to Jake, age 11, ASD, and , age 12, NT) 2a. Re: This is interesting! !!!!!!!!! ! Posted by: "pkuenstleraol (DOT) com" pkuenstleraol (DOT) com Date: Wed Nov 18, 2009 4:27 am ((PST))Wow, this makes sense!! How do we get Respen-A? I had just been wondering about Epidurals. How did you come about this information? Love and blessings, Pat K A new treatment for autism appears to normalize brain function, according to Nashville physician Fred S. Starr, MD, FAACAP, BCIA-EEG. In addition to high serotonin levels, autistic children have a characteristically common "u" EEG pattern reflecting impaired brain function, particularly in areas of the brain responsible for social interaction, communication, speech and bonding. However, Quantitative EEG's conducted by Dr. Starr on autistic children after three weeks on the medication Respen-A showed that the children's brain patterning changed to "normal" patterning. Starr says that behavioral improvement was also "evident". "Speech, interaction and social skills improved markedly in patients using Respen-A, and displays of frustration and anger markedly diminished," Starr said. The theory behind the use of Respen-A was developed by private researcher Elaine DeLack, Stanwood, WA. Unlike theories that center on negative reaction to vaccinations, DeLack looked at exposure to a commonly used drug used during delivery, and at brain enzymes that affect the brain both at birth, and again as the child enters childhood. DeLack's hypothesis (which can be viewed in slide show format at www.Neuro-Med. net) connects autism to the use of epidurals during childbirth. Epidurals were introduced into this country in the 1960's. By the mid-80's, 22 percent of women received an epidural during delivery. In the mid-90's, the number grew to 67%. Today, nearly 90% of women receive an epidural during pregnancy. However, DeLack contends that it may not be the epidural procedure, but the drugs given in conjunction with the procedure, particularly the drug Pitocin, that has contributed to increasing numbers in autism. Pitocin crosses the placenta to the infant's system during childbirth. The drug requires adequate production of an enzyme found in the liver (CYP 3A4) in order to rid it from the body. If the infant has a genetic inadequacy of the CYP 3A4 enzyme (found more often to be lacking statistically in boys than girls), the drug's intensity could become elevated in the infant's system, and build with another naturally occurring neurotransmitter that plays a key role in brain development: the hormone Oxytocin. DeLack theorizes that the addition of Pitocin into the bloodstream of infants without adequate CYP 3A4 genetic enzymes, causes brain development to "shut off" early, stunting crucial neuro-development. DeLack hypothesizes that a second enzyme may explain why autism shows up in many children around the age of three. The enzyme MAO-A is essential in regulating serotonin levels in the brain. In the first years of life, MAO-A levels remain high, assisting brain function. The impact of MAO-A may, in fact, cover symptoms of brain impairment in infants and toddlers. MAO-A levels diminish as the child ages - allowing serotonin levels to rise, impacting the areas of the brain associated with communication, speech, emotion and bonding. Respen-A curbs the level of serotonin in the autistic brain.+ Read more: is.gd/4WCX3 -- Kate Myers Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 25, 2009 Report Share Posted November 25, 2009 What about the respen-a was he not impressed about? Why wouldn't he prescribe it to any of his patients? melissa Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 26, 2010 Report Share Posted May 26, 2010 , Respen-A has been an excellent medicine for my youngest daughter. She is 11 years old. She is talking a lot more. We are hearing new language. She is spontaneously commenting more about her environment and also things that are on her mind. She is more conversational. She is definitely more social also. Also her overall mood has improved significantly. Her emotions used to be a rollercoaster throughout the day. She is more even now and really happy throughout the entire day now. She has been on Respen-A for 56 days. We have not seen a plateau yet. About every couple of weeks she makes another leap forward in all the above areas. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 26, 2010 Report Share Posted May 26, 2010 http://www.respen-a.com/ Should be info there MAndi x In a message dated 26/05/2010 23:10:54 GMT Daylight Time, lucy_hutson@... writes: Hiya, where can you get Respen-A from in the UK? Is it presciption only?I have been taking my 3 year old boy to a Homeopath.Should I be asking for this from the homeopath?Lucy Quote Link to comment Share on other sites More sharing options...
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