Has anyone tried chelating with n-acetylcysteine or with DMSA and NAC together?

[Guest guest]

I saw this study on mercury excretion with NAC showing it caused an elevated

urine excretion. Has anyone tried chelating with n-acetylcysteine or with DMSA

and NAC together? It certainly makes you think it ought to be considered:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1533084/

The present study demonstrates that oral administration of N-acetylcysteine

(NAC), a widely available and largely nontoxic amino acid derivative, produces a

profound acceleration of urinary methylmercury excretion in mice. Mice that

received NAC in the drinking water (10 mg/ml) starting at 48 hr after

methylmercury administration excreted from 47 to 54% of the 203Hg in urine over

the subsequent 48 hr, as compared to 4-10% excretion in control animals. When

NAC-containing water was given from the time of methylmercury administration, it

was even more effective at enhancing urinary methylmercury excretion and at

lowering tissue mercury levels. In contrast, excretion of inorganic mercury was

not affected by oral NAC administration. The ability of NAC to enhance

methylmercury excretion when given orally, its relatively low toxicity, and is

wide availability in the clinical setting indicate that it may be an ideal

therapeutic agent for use in methylmercury poisoning.