Some more research on autoimmunity

[Guest guest]

Hi everyone againFrom the same Nature Reviews Immunology (October 2009) is another article which seems to support the hypothesis behind the use of LDN."Rejuvenating the immune system in rheumatoid arthritisCornelia M. Weyand, Hiroshi Fujii, Lan Shao & Jörg J. Goronzyp583 | doi:10.1038/nrrheum.2009.180Premature aging of the immune system, driven by defective DNA maintenance and repair, could be responsible for the pathogenesis of RA. The authors discuss the phenomenon of premature immunosenescence in RA, and suggest that 'resetting' the immune system could be a novel therapeutic concept."This ties in with the hypothesis that the regulatory effect of the increased endorphins can "reset" the immune system.I have written to one of the authors of this research article as well suggesting he could investigate the use of LDN.NanFrom: Lee <nancy_lee.2154@...>low dose naltrexone Sent: Tue, 6 October, 2009 6:48:40 AMSubject: Re: [low dose naltrexone] Re: Anyone here using LDN with auto-immune thyroid disorders?

Hi allHere is an article from Nature Reviews Immunology (October 2009) which says "The ultimate goal of therapy for patients with active rheumatoid arthritis (RA) and other autoimmune diseases is to restore normal immune function rather than to achieve broad immunosuppression. Evidence has accumulated over the past decade that regulatory T cells (TREG) could be an ideal target for therapies to induce durable remission of autoimmune and inflammatory disease (reviewed elsewhere1). TREG are ideal for this purpose because they suppress inflammation in an antigen-specific manner. Furthermore, short-term therapy with TREG can lead to long-term inhibition of autoimmune disease in mouse models, and immunomodulatory agents can affect numbers and functioning of TREG in both mice and humans. Thus, approaches that bolster numbers or functioning of TREG could achieve selective and durable inhibition of pathologic inflammation without blocking protective immune responses against infection. "and

concludes:"Thus, approaches that bolster TREG numbers and functions could be a fruitful means of selectively and durably inhibiting pathologic inflammation without blocking protective immune responses against infection."Now isn't that what the LDN lobby has been saying all along? I shall write to the

authors of this article and suggest they extend their studies into the use of LDN for this purpose.You can read the full article here:http://www.nature. com/nrrheum/ journal/v5/ n10/full/ nrrheum.2009. 183.htmlNanFrom: z100a2002 <zahavi100planet (DOT) nl>low dose naltrexoneSent: Tue, 6 October, 2009 5:19:09 AMSubject: [low dose naltrexone] Re: Anyone here using LDN with auto-immune thyroid disorders?

here you can read some experience of ldn and hashimoto

https://ldndatabase .dabbledb. com/page/ other/AGRndwmv

here you can read suggestion how to go with ldn and auto-immune thyroid

http://www.ldndatab ase.com/forum/ showthread. php?t=70

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> Hi all, I'm a 42 year old man who was DX'ed with Hashimotos thyroiditis 5 years ago. I've had a very bad 2-3 years of symptoms that defied any doctor's explanation or treatment until I learned, this past spring, that I have Graves disease instead of, or in combination with, Hashis. I have a RX from one of my docs for 3mg of LDN but he really doesn't know much about it. I've seen the warnings about starting LDN at 1.5mg if you have thyroid disorders so I would at least need to get him to re-write that RX. I'm looking for/hoping that someone here is using LDN to treat a similar condition.

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> Thanks,

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