Guest guest Posted August 23, 2009 Report Share Posted August 23, 2009 I am so glad you figured out why you were not doing well and able to start it again...thank you for sharing your progress! I too have had very vivid dreams but mine were comical and not scary like some have reported...continued success!! Terri From: Garnet <garnet@...>Subject: [low dose naltrexone] First Week Back On LDN"LDN List" <low dose naltrexone >, "LDN_Users" <LDN_Users >, "LDNandIBD" <LDNandIBD >Date: Sunday, August 23, 2009, 3:48 PM My first experience with LDN for 19 days, after a few days, included severeheadaches, jaw pain and immediate sleep disturbance. The headaches were the worstpart and after allowing 2.5 weeks adjustment period I stopped because the headacheswere so severe.After experimenting with my grain and dairy consumption it does not appear that theheadaches were due to gluten or casein allergy. Although I continue to use much lessgrain and dairy because they are acidifying and I feel better eating less of them I havenot totally eliminated either permanently.I started again at 1 mg LDN, a week ago tomorrow. Last night I increased LDN to 2.5 mgfrom 2.0 mg the previous two nights. I noticed again a slight increase in wakefulness andvivid dreams but it seems that in general it has taken me only two nights to adjust to eachincrease in dose. I am taking 2 mg SL (fast release) Melatonin and 6 mg slow release toover come any wakefulness. I am also taking a 2 hour nap in the afternoon. I have beenmore sleepy than normal during the day and fortunately can give into it and sleep.If I continue to progress at this rate I should be up to 4.5 by Monday of next week.I was not sure how fast I would increase my dose when I started LDN again. I was veryconcerned about getting severe headaches again.I now know that the first time I tried LDN I was getting too much by topically applyingthe LDN liquid with 10% DMSO. Orally only about 10 -14% of LDN actually makes it intothe circulation. With DMSO I am certain that much more made it due to the topical routeby passing a first pass through the liver where a ~90% of the LDN is broken downbefore it gets to the body when taken orally.Some have questioned why I chose to differ from tried and true methods of delivery forLDN. I was attempting to work out a way to make a topical LDN myself, after looking intothe transdermal LDN cream. I still feel this is possible with DMSO but the liquid concentrationof LDN would need to be more on the order of 0.1 mg / ml, with a max dose of .45 mg.It is possible that I will work with this again in the future but for now I first want to establishif I am able to adjust to an oral dose of 4.5 mg and what benefits I notice so that I have away to determine if I get the same benefit from a 0.1 mg/ml topical with DMSO dose.I am not suggesting that anyone else do this. Just reporting on my experiences and thoughts.I would prefer to take LDN as a topical rather than orally. I know in the long run that topicalmedications are more sustainable for me. I dislike taking pills or bitter liquids and find thatI have to work harder to make myself remember to take them. I seem to conveniently startto forget, especially when any symptoms that I was working to eliminate have stopped. Inmy case I am taking LDN for chemical and seasonal allergy elimination and diseaseprevention.Garnet Quote Link to comment Share on other sites More sharing options...
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