When starting this LDN(Low Dose Naltrexone) therapy

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When starting this LDN(Low Dose Naltrexone) therapy, there may also be some

initial transient, though temporary, increase in symptoms.

Experience in using this method has demonstrated most commonly, such as

disturbed sleep, occasionally with vivid, bizarre and disturbing dreams,

tiredness, fatigue, spasm and pain.

Rarely, other transient symptoms have included more severe pain and spasm,

headache, diarrhea or vomiting. These additional symptoms would appear to be

associated with the previous frequent use of strong analgesics, which

effectively create an addiction and dependency, thus increasing the body's

sensitivity to pain. This temporary increase in symptoms may also perhaps be

explained when we consider the manner in which this drug is expected to work.

Because LDN stimulates the immune system and many of the drugs routinely used by

the NHS in treatment further suppress the immune system, LDN cannot be used in

company with steroids, beta interferon, methotrexate, azathioprine or

mitozantrone or any other immune suppressant drug. If there is any doubt, please

submit a full list of the drugs you are presently taking so that their

compatibility may be assessed.

In addition, because LDN will also block the analgesic effects of any opiate

drugs (includes codeine, dihydrocodeine, morphine, pethidine or diamorphine)

presently being taken, the use of LDN will initially greatly increase the level

of pain experienced. It is therefore advisable that any opiate-like drugs be

discontinued at least two weeks before this treatment is initiated. When

starting the treatment it is essential that any untoward or adverse side-effects

are reported immediately so that the treatment process can be further assessed

and, if necessary, modified.

Dr. M R Lawrence

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