Guest guest Posted September 17, 2003 Report Share Posted September 17, 2003 I'm glad you got good results with CMO. I tried it, but it caused a major fibromyalgia flareup. I felt like every nerve in my body had been sandpapered. -- el (andrea at oro dot net) " wake now! Discover that YOU are the song that the morning brings... " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 24, 2005 Report Share Posted July 24, 2005 Jody: I will try to attach/copy some of their info here for you. I hope it reads for you. I use one bottle of $21 (plus tax/s/h) per month and it is an inexpensive help for me. By the way, the maintenance product did not work for me, I have to stay on CetylPure (two twice daily). Sorry it's so long but print it out for your mom. It's worth reading and keeping on file. in La Selva Beach CA From www.discount-vitamins-herbs.net: CetylPure ; (CMO complex) ; Natrol; 550 mg; 120 capsules Item Number: N3239 Bottle Date: Sept 2006 Manufacturer: Natrol MSRP: $29.99 $21.00, 12 for $228, 4 for $80 You save: $8.99 For the relief of joint discomfort associated with aging and exercise.* Natrol's CetylPureT is an exclusive and patented blend of cetyl myristoleate, a naturally occurring fatty acid. This revolutionary compound works to lubricate joints and helps to promote mobile joint function.* CetylPureT is a cutting-edge compound that promotes the relief of joint discomfort following exercise.* As our bodies age, the ability to produce some of the nutrients necessary for joint function and cartilage building declines. Natrol's CetylPureT helps to nourish and maintain the natural lubricating fluid in joints and cartilage.* Natrol CetylPure is 12% Cetyl Myristoleate in a complex of other fatty acid esters, for example cetyl stearate, cetyl palmitate, cetyl palmitoleate, cetyl oleate, and cetyl myristate, in a 2-tablet dose of 1,100mg. With this blend, you do NOT need to take other digestive enzymes. View more info on CMO a.. If you are tired of the pain; b.. If you want to hear about other joint pain sufferers' or athlete's experiences; c.. If you use too much aspirin, ibuprofen or NSAIDs and you can spare 5 minutes, call Roxanne toll free M-F 8:30-5 in California at 800-401-9186. Serving Size: 2 capsules Servings per Container: 60 Each Serving Contains %DV Cetyl Myristoleate Proprietary Blend 1,100 mg (CetylPureT) ** ** Daily Value (DV) Not Established Suggested Use: Take 2 capsules twice daily with a meal. Use CetylPureT for 30 days and follow with Natrol's CMGT (Cetyl, MSM & Glucosamine) as a maintenance program. Store in a cool, dry place. Keep out of reach of children. Other ingredients: Silica, Magnesium stearate, gelatin. NO yeast, wheat, milk, egg, soy, glutens, artificial colors or flavors, added sugar, or preservatives. Warning: Keep out of the reach of children. Keep in a cool dry place, tightly closed. Distributed by Natrol®, Inc. Chatsworth, CA 91311 Frequently asked questions: a.. What is CetylPure made from? CetylPure is a blend of cetyl myristoleate which is from beef marrow and natural fatty acids. Do not confuse this brand with CMO derived from plants or beef tallow (hardened fat). a.. Do you need to take digestive enzymes with CetylPure? No, with this blend of complex fatty acid esters, for example cetyl stearate, cetyl palmitate, cetyl palmitoleate, cetyl oleate, and cetyl myristate, you do NOT need to take other digestive enzymes. a.. How long should a person take CetylPure? Be sure to finish the first bottle. Continue taking it until you get the results you desire. The maintenance product is CetylPure with MSM & Glucosamine. * The FDA has not evaluated this statement. This product is not intended to diagnose, treat, cure or prevent disease. -------------------------------------------------------------------------------- Home | Specials | Product Info | Health news | FAQs | About us | Blog | Links | Links2 | Links3 | Sitemap | Contact us Alphabetic Product Listing | Products by Category | Links4 | Links5 | AHCC TOLL FREE : 800-401-9186 Cetyl Myristoleate (CMO) for former Vioxx Users 1 of 3 : next >> -------------------------------------------------------------------------------- [Cetyl Myristoleate Functions | An Update on CMO ] [History of Cetyl Myristoleate | Subsequent CMO Research ] [Mechanisms of CMO Action | Recommended CMO Dose | Clearing CMO Confusion ] [Our Customer Testimonials] a.. FDA Issues Health Warning Against Vioxx, Merck Recalls Drug b.. Cetylated Fatty Acids Improve Knee Function in Patients with Osteoarthritis c.. CMO (Cetyl Myristoleate) in the Treatment of Fibromyalgia: An Open Pilot Study d.. Verification of the Anti-Arthritis Properties of Cetyl Myristoleate Administered Orally and by Injection Cetyl Myristoleate is used as a complementary and alternative medication for joint health issues. Many of our customers use CMO in conjunction with pain medication prescribed by their Doctor. Former Vioxx users may consider using CMO in conjunction with an alternative pain medication prescribed by their Doctor. They often find that they can significantly cut down on the pain medication after taking CMO for a while (of course, under the supervision of their doctor). Cetyl Myristoleate Functions Cetyl Myristoleate (CMO) seems to function in at least four different ways. One of the first observations noted when favorable CMO results are seen is the lubricating quality of Cetyl Myristoleate (CMO). Decrease or loss of morning stiffness is commonly noted shortly after commencing CMO treatment. Next, Cetyl Myristoleate functions as an anti-inflammatory. Lessening of swollen digits is often seen after the 4th or 5th week of Cetyl Myristoleate treatment. Third, Cetyl Myristoleate CMO functions as an immunomodulator or immune system regulator. Cetyl Myristoleate's ability to regulate or calm down hyper-immune responses is one of the most exciting qualities and shows that CMO may be helpful in addressing the symptoms related to many autoimmune diseases. And finally, Cetyl Myristoleate functions as an analgesic or painkiller and CMO has been helpful for many sufferers of muscle tension headaches and fibromyalgia. An Update on Cetyl Myristoleate (CMO) Chuck Cochran, D.C. I can't believe it, but it's been over four years since I first wrote a small booklet entitled Dr. Chuck Cochran Discusses Arthritis & Cetyl Myristoleate. As you can imagine a lot has transpired since that time. We now have quite a few healthcare practitioners who use Cetyl Myristoleate (CMO) regularly in their offices and Cetyl Myristoleate is being sold through several nutritional lines in health food stores. Several multi-level companies now offer Cetyl Myristoleate (CMO) and related products in their lines, and recently, Cetyl Myristoleate was put in a formula to treat arthritis in dogs. Cetyl Myristoleate has also been written about in Atkins', M.D. most recent book entitled Vita-Nutrient Solution - Nature's Answer to Drugs. And Sherry , M.D., for her soon-to-be-completed book on chronic pain, recently interviewed me about Cetyl Myristoleate. I also had the fortunate opportunity to be interviewed by Total Health (Volume 21, No. 1). I've found that there's a big difference in all of these CMO products, however, and so I appreciate the opportunity to share some of the information that I've gathered since I was first introduced to Cetyl Myristoleate - this marvelous molecule. The History of Cetyl Myristoleate For those of you who have not heard or read about cetyl myristoleate, let me give you just a little background. The Cetyl Myristoleate discovery occurred during a two-year period from 1962 to 1964 by Harry W. Diehl while on a personal quest to find a cure for arthritis. Harry was a research chemist working in sugar metabolism at the National Institutes for Health in Bethesda, land. During his time there, over 40 years, he was responsible for isolating and identifying over 500 chemical compounds. Many of these were patented. His most notable discovery, prior to Cetyl Myristoleate, was a sugar used in the preparation of Dr. Jonas Salk's oral polio vaccination. His discovery of Cetyl Myristoleate actually occurred in a laboratory that he had set up in his own home. The story of how he isolated the Cetyl Myristoleate molecule that may one day be hailed as the most significant nutritional discovery of the 20th century and nature's answer to arthritis is simply wonderful. Unfortunately, I can't relate the entire story in this short article. Hopefully, someday someone will write the story of this very intuitive researcher. In a nutshell, this is what Harry's research revealed: a.. Mice are immune to arthritis. b.. The molecule that provides this immunity is Cetyl Myristoleate (the cetyl alcohol ester of the fourteen carbon chain fatty acid myristoleic acid). c.. Cetyl Myristoleate circulates in the bloodstream of mice at approximately 350 mg / kg bodyweight and with proper doses of Cetyl Myristoleate extracted from mice (450 -500 mg / kg body weight), he could provide rats with 100% immunity to adjuvant-induced arthritis. d.. After injecting the Cetyl Myristoleate into the rats, the highest concentrations were found in the liver. Harry developed a way of synthesizing Cetyl Myristoleate by combining cetyl alcohol with myristoleic acid and found that the synthesized form of Cetyl Myristoleate was just as effective in providing rats immunity to adjuvant-induced arthritis as the naturally occurring form (extracted from mice). Subsequent CMO Research A more recent Cetyl Myristoleate study, performed by H. Siemandi, M.D., Ph.D., was published in the August / September 1997 issue of the Townsend Letter for Doctors & Patients. This Cetyl Myristoleate study was performed as a randomized, double blind, placebo parallel trial with 382 patients who had been diagnosed with degenerative joint disease (DJD or osteoarthritis), rheumatoid arthritis, and psoriatic arthritis. This group was divided into three groups for testing. The first Group A received a complex of fatty acids (90 grams) containing 12% Cetyl Myristoleate, the second Group B received the same complex of CMO fatty acid esters plus glucosamine hydrochloride, sea cucumber (a sea animal commonly found in the Great Barrier Reef in Australia - related to the Starfish), and hydrolyzed cartilage, and the third Group C received a placebo. Treatment consisted of a one-month protocol. Outcome measures included a variety of patient-reported, clinical, laboratory, and radiographic assessments. The results were as follows (expressed in percent improvement): Group A Group B Group C Treatment Response 63.3% 87.3% 14.5% M.D. Overall Assessment 58.1% 84.2% 13.9% Patient Overall Assessment 59.2% 88.2% 16.1% Joint Swelling Score 47.5% 77.2% 21.1% Mechanisms of CMO Action and Indications The exact mechanisms of Cetyl Myristoleate action are not fully understood. Several theories have been presented, but as of today, there has been no research in this regard. Being a fatty acid ester, one mechanism being presented is that Cetyl Myristoleate somehow manipulates the production of the favorable prostaglandins, (series 1 and/or 3) and leukotrienes over the unfavorable prostaglandins of the 2nd series and pro-inflammatory leukotrienes. Prostaglandins and leukotrienes are unsaturated fatty acids that regulate many local metabolic processes including inflammation, platelet aggregation, pain, fluid balance, and nerve transmission. These effects could be accomplished by inhibition of the arachidonic acid cascade and the cyclo-oxygenase and lipoxygenase pathways. Another mechanism being discussed is that these CMO fatty acid esters are somehow incorporated into the phospholipid cell membranes and alter cell membrane permeability and receptor sites. This could explain the possible theory of altering T-lymphocyte function during the hyper-immune response related to autoimmune diseases. Although the mechanisms are unknown, we can clinically observe Cetyl Myristoleate's effects. Cetyl Myristoleate seems to function in at least four different ways. One of the first observations noted when favorable results are seen is the lubricating quality of Cetyl Myristoleate. Decrease or loss of morning stiffness is commonly noted shortly after commencing CMO treatment. Next, Cetyl Myristoleate functions as an anti-inflammatory. Lessening of swollen digits is often seen after the 4th or 5th week of Cetyl Myristoleate treatment. Third, Cetyl Myristoleate functions as an immunomodulator or immune system regulator. Cetyl Myristoleate's ability to regulate or calm down hyper-immune responses is one of the most exciting qualities and shows that Cetyl Myristoleate may be helpful in addressing the symptoms related to many autoimmune diseases. And finally, Cetyl Myristoleate functions as an analgesic or painkiller and CMO has been helpful for many sufferers of muscle tension headaches and fibromyalgia. Recommended CMO Dose We have found that many of those individuals who have taken Cetyl Myristoleate (CMO), and have not responded, have often taken doses far below what is recommended. Results are related to the quality of the product as well as the amount of Cetyl Myristoleate taken orally (therapeutic or loading dose). If we do a little mathematics, and use the amount of CMO circulating in the bloodstream of mice as a comparison (350 mg / kg), we conclude that a 160-pound person could require up to 24.5 grams CMO. Fortunately, possibly because human and mouse metabolism differ greatly, we have found that doses of 12 grams to 18 grams of elemental Cetyl Myristoleate as a therapeutic or loading dose taken over a three to four week period of time works fantastically well. However, there are those individuals that require a second CMO protocol. And once the desired results have been achieved, there are many individuals that benefit from taking much smaller, perhaps daily, CMO maintenance doses. Concerning the quality, there is a wide degree of very diverse Cetyl Myristoleate products available today. In fact, some of the CMO formulas have no Cetyl Myristoleate in them at all! Before purchasing any of these formulas, please read the label to determine exactly how much Cetyl Myristoleate is available. It is imperative that the formula contains a minimum of 12% CMO levels. If the levels are below this amount, you'll probably have to take a wheelbarrow full before seeing any results! In other words (let's do a little math), if you're trying to achieve a therapeutic dose of 12 grams of CMO and the CMO levels are at 12%, you will need a total of 100 grams of mixed fatty acid esters in this particular CMO formula. If the CMO levels are at 20%, you will need a total of only 60 grams. If the manufacturer has not listed the percentages and the total amount of fatty acid ester complex, I would be very hesitant in purchasing that particular product. Without this information, you have no way of determining how much you need to take, for how long, and what would be a good maintenance dose. Clearing CMO Confusion There are many different Cetyl Myristoleate and related products available today. There are several which, either through ignorance or unethical marketing, have contributed to extensive confusion in the nutritional and healthcare industry. There are several issues that I'd like to address in this regard. First, Cetyl Myristoleate (CMO) is not CMOTM. CMOTM is a trademarked product that is being sold as cerasomal cis-9 cetyl myristoleate, an analog of cetyl myristoleate. The term cerasomal (waxy body?) is not in your chemistry texts and was constructed by the manufacturer to set his product apart. The term analog is defined as a similarly structured molecule. In other words, CMOTM contains a similar molecule, but is not Cetyl Myristoleate. Chemical analysis performed on several occasions, using Gas Chromatography, Mass Spectrometry, and Flame Ionization Detection has revealed very little, if any, Cetyl Myristoleate in this product. Unfortunately, the manufacturer, as of today, has not disclosed exactly what his product is. Another embarrassing mix up is that, at least, one of the manufacturers started with a raw material that contained high levels of myristic acid (C14:0) instead of myristoleic acid (C14:1). Myristic acid is the saturated analog of myristoleic acid and when esterified with cetyl alcohol produces Cetyl Myristate, not Cetyl Myristoleate. Before the sophisticated diagnostic procedures to analyze for CMO were developed, many of these products were analyzed using improper or inadequate methods. These products are now on our health food store shelves and in the MLM industry being sold as Cetyl Myristoleate, but in fact are Cetyl Myristate. Interestingly, there have been many who have experienced benefits from these Cetyl Myristate products. And I have found that, in one particular formula, the Cetyl Myristate seems to enhance the effectiveness of the Cetyl Myristoleate. They may form a true synergism. And, finally, all Cetyl Myristoleate products are not created equally. Chemical analysis of several different products has revealed that the CMO levels range from 1% up to 40%. And to add to the confusion, I have found products that contain lower percentages of CMO (20% - 30%) that seem to work better than the Cetyl Myristoleate products with higher levels. Please note that there are no CMO products today that are 100% pure. With all of these products you will find a complex of other fatty acid esters, for example cetyl stearate, cetyl palmitate, cetyl palmitoleate, cetyl oleate, and cetyl myristate, in different proportions. What we're now finding is that some of these fatty acid esters may inhibit the positive effects of the Cetyl Myristoleate, while others work with the CMO, as I mentioned above, in a cooperative way. For those of you technical individuals out there, Gas Chromatography - Flame Ionization Detection (GC-FID) analysis is now considered one of the most accurate techniques for detecting these fatty acid esters. Here's something that you may also find interesting. Further analysis of the product used by Dr. Siemandi in his study showed that it actually contained 10.8 grams of Cetyl Myristoleate, and not 18 grams, as stated in his report. And one very current analysis of this same material indicated that the CMO levels could have been only 9 grams delivered in a one- month protocol. It's truly amazing what results were achieved with only 9 or 10 grams of active ingredient! And for those of you who are suffering with any types of aches or pains, you and Cetyl Myristoleate deserve to get to know each other! God speed on your road to health! Reprinted with exclusive permission by Natrol, Inc. Cetyl Myristoleate (CMO) << back : 2 of 3 : next >> -------------------------------------------------------------------------------- [introduction | Cetyl Myristoleate | The CMO Quest | CMO Chemistry] [Experimentation | A Hiatus | CMO Cures: Diehl's Arthritis] [Clinical Observations and CMO Usage | Cases] [Optimizing the Effects of CMO | Reported Results | Dosage] [Contraindications and Toxicity | References] Cetyl Myristoleate - A Unique Natural Compound Valuable in Arthritis Conditions A Sponsored Article by Dr. Cochran and Dr. Dent September 1997 Townsend Letter for Doctors and Patients 07-31-1997 ISSUE #168 p. 70-74 Introduction Arthritis is a disease of epidemic proportions, but it has been around for so many centuries that it is considered by most people as a part of growing old or a consequence of physical injury. Arthritis is in fact a far more complex disease than is generally known. For instance, Dorland's Medical Dictionary describes 27 different types of arthritis, and that does not include such diverse conditions as systemic lupus erythematosus, scleroderma, fibromyalgia, and numerous other conditions which some authorities consider to be types of arthritis.1 One authority states that there are approximately 100 causes for arthritis. Arthritis is thought to affect more than 50 million Americans, and is generally accepted to be the leading cause of movement limitation and disability. Arthritis deserves and receives a great deal of research and medical attention. There are hundreds of drugs, procedures, and medical aids and devices directed at coping with the many manifestations of arthritis. Given this degree of complexity, certainly no one agent alone could ever be expected to manage or cure " arthritis " in its entirety. New agents take their place in the spectrum and make a contribution. Now there is a relatively new discovery of a natural substance, cetyl myristoleate (CMO), which shows promise of making a great contribution in non-infective types of arthritis. Cetyl Myristoleate Cetyl myristoleate was discovered and isolated by one person, working alone, on a quest to find a cure for arthritis. Harry W. Diehl, while employed by the National Institute of Arthritis, Metabolism, and Digestive Diseases, specialized in sugar chemistry. He used his chemical knowledge and research instincts to great advantage, identifying and characterizing over 500 compounds, several of which were patented by the National Institutes of Health (NIH). His most significant discovery before cetyl myristoleate was a method of synthesizing 2-deoxydextroribose, a sugar used in the preparation of oral polio vaccine by Dr. Jonas Salk. Diehl's interest in discovering a way to help victims of arthritis began over 40 years ago when his friend and next-door neighbor, a carpenter, developed severe rheumatoid arthritis. His condition deteriorated over time until he became disabled. The neighbor had a family to support, but his arthritis made that impossible. Diehl is a deeply religious man whose feelings overwhelmed him as his friend's condition worsened. Harry thought, " Here I am working at the National Institutes of Health, and I have never seen anything that was good for curing arthritis. " 4 He decided to establish a laboratory in his home and embark on a search for something to relieve the pain and disability of his neighbor and the millions of people who suffer from arthritis. Unfortunately, he was too late to help the neighbor, but Diehl's research did lead to the discovery of cetyl myristoleate, which may someday be hailed as one of the significant nutritional discoveries of the 20th century. The CMO Quest As a researcher, Diehl knew that finding a cure for arthritis first meant inducing arthritis experimentally in research animals. He started with mice, and quickly realized that he was unable to induce arthritis in them. Diehl said he tried every way he could to give those mice arthritis, but they just would not get it. Then, he contacted a researcher in California who wrote to him, " If you or anyone else can give mice arthritis, I want to know about it, because mice are 100% immune to arthritis. " 5 At that moment, Diehl's research instincts told him that what he wanted was already somewhere in those mice. It was a long, tedious job, working on his own in his spare time, but Diehl finally found the factor - cetyl myristoleate - that protected mice from arthritis. As Diehl said, " CMO didn't come on a silver platter to me, but after years of chemical sleuthing and just old-fashioned chemical cooking, I found it! " On thin layer chromatography of methylene chloride extract from macerated mice, Diehl noticed a mysterious compound, which was subsequently identified as cetyl myristoleate. As Diehl was to prove, cetyl myristoleate circulates in the blood of mice and makes them immune to arthritis. Cetyl myristoleate is now known to exist in sperm whale oil and in a small gland in the male beaver. At this time no other sources in nature are known to contain cetyl myristoleate. While the first amounts of cetyl myristoleate for experimentation were extracted from mice, Diehl quickly developed a method for making cetyl myristoleate in the lab by the esterification of myristoleic acid. CMO Chemistry Cetyl myristoleate, an oil, is the hexadecyl ester of the unsaturated fatty acid cis-9-tetradecenoic acid. The common name for the acid is myristoleic acid. Myristoleic acid is found commonly in fish oils, whale oils, dairy butter, and kombo butter. The chemical formula for cetyl myristoleate is (Z)-ROCO(CH2)7CH=CH(CH2)3CH3. Cetyl myristoleate was unrecorded in chemical literature until Diehl's discovery was reported. The current Merck Index of Chemicals does not list cetyl myristoleate. A search of Chemical Abstracts lists Diehl's method of extracting cetyl myristoleate from mice but contains no reference to cetyl myristoleate prior to his 1977 patent. Experimentation To test his theory that mice are immune to arthritis because of cetyl myristoleate, Diehl began to experiment on laboratory rats. This research was reported in an article written in conjunction with one of his colleagues at NIH in the Journal of Pharmaceutical Sciences.6 In summary, this paper reports that ten normal mice were injected in the tail with Freund's Adjuvant (heat-killed desiccated Mycobacterium butyricum) to which rats and certain other rodents are susceptible. In a period of 10-20 days, no noticeable swelling developed in the legs or paws. Mice in a second group were injected in the left hind paw. Again, after 10-20 days, no swelling was detected as determined by comparison of the measurements of paws at the time of injection. Then, a group of rats was injected with cetyl myristoleate, and 48 hours later, they were given the arthritis-inducing Freund's adjuvant. A control group of rats was given Freund's adjuvant only. Both groups of rats were observed for a total of 58 days with respect to weight change, hind and front leg swelling, and general well being. All rats receiving only Freund's adjuvant developed severe swelling of the front and hind legs, lagged in weight gain, and were lethargic and morbid. Those receiving cetyl myristoleate before receiving Freund's adjuvant grew an average of 5.7 times as much as the control group and had little if any evidence of swelling or other symptoms of polyarthritis. The authors concluded that it was apparent that cetyl myristoleate gave virtually complete protection against adjuvant-induced arthritis in rats. Furthermore, a 1:1 mixture of cetyl myristoleate and a homologue, cetyl oleate, gave results not significantly different from administering cetyl myristoleate alone. A Hiatus Diehl patented his discovery in 1977, receiving a use patent for rheumatoid arthritis. He then sought pharmaceutical companies to conduct human trials with cetyl myristoleate, but none were interested in his discovery. Perhaps the lack of interest was because cetyl myristoleate was a natural substance and could not be granted a product patent, or maybe because drug companies know they will have to run through 25,000 to 35,000 substances before they find one that makes it to market. Diehl had made a major nutritional discovery, and no one was interested! Being a scientist, not a marketing expert, Diehl let his discovery lay dormant for about 15 years. Cetyl Myristoleate Cures: Diehl's Arthritis As Diehl got older, he began to experience some osteoarthritis in his hands, his knees, and his heels. His family physician tried the usual regimen of cortisone and non-steroidal anti-inflammatory drugs without much effect on the course of the disease. Finally his physician told Harry he could not have any more cortisone. " So, " Diehl said, " I thought about my discovery, and I decided to make a batch and use it on myself. " He did, and successfully cured himself of his osteoarthritis. Many of his family members and friends became aware of the relief Diehl got from his discovery, and they wanted to try it too. Time after time, people with both rheumatoid and osteoarthritis received astounding relief with cetyl myristoleate. Before long, family members and friends grew into customers, and cetyl myristoleate appeared on the market as a dietary supplement in 1991. Clinical Observations and CMO Usage In common with many other natural substances and drugs, the exact mechanism of cetyl myristoleate's physiologic activity is unclear. As a fatty acid ester, it appears to have the same characteristics as the essential fatty acids, linoleic and alpha linolenic acids, except stronger and longer lasting. These fatty acids are referred to as " essential fatty acids " because the human body cannot make them and we must ingest them in our diets. These EFA's truly are essential to normal cell structure and body function and function as components of nerve cells, cell membranes, and hormone-like substances known as prostaglandins. Many of the beneficial effects of a diet rich in plant foods is a result of the low levels of saturated fat and the relatively higher levels of EFA's. While a diet high in saturated fat has been linked to many chronic diseases, a diet low in saturated fat but high in EFA's prevents these very same diseases.7 The use of EFA's over an extended period of time has been shown to decrease the pain, inflammation, and limitation of motion of arthritis. The difference between the activity of EFA's and cetyl myristoleate is that the quantity required and the period of time over which EFA's are taken are markedly longer. Cetyl myristoleate is taken in a one month course of about 13 grams, while EFA's must be taken over extended periods, sometimes many years, and intake varies widely from hundreds to thousands of grams. Cetyl myristoleate seems to have properties in common with EFA's, but it acts faster and lasts longer. Because EFA's are necessary for normal functioning of all tissue, it is not surprising that the list of symptoms of EFA deficiency is a long one. In chronic inflammatory processes, the supply of EFA's is depleted. Cetyl myristoleate appears to have the ability to correct the imbalance created by chronic inflammation. Like EFA's, maybe cetyl myristoleate turns off the fires of chronic inflammation by serving as a mediator of prostaglandin formation and metabolism. Venous blood from the gastrointestinal tract is carried to the liver via the portal vein. With the exception of intestinal chylomicrons that enter the lymphatics, all absorbed products pass initially through the liver, and in most instances are extracted or modified before passage into systemic circulation.9 Since all fatty acids enter systemic circulation through the liver, an oil like cetyl myristoleate would begin its systemic circulation from the liver also. It is speculated that cetyl myristoleate stimulates the production of immunoglobulins and series 1 and 3 prostaglandins, which could be one explanation for why cetyl myristoleate has such potent effect in autoimmune and inflammatory conditions. Cases Here are some cases involving the use of cetyl myristoleate from the author's practice. Leona - She is a 64-year-old mother of five who has been developing degenerative changes in her fingers over the last 15 years. She plays the piano frequently and had to reduce the amount of playing time as a result of the arthritis pain in her fingers. ANA titers have been mildly elevated over the years and rheumatoid disease has been diagnosed in several of her ancestors and one sibling. Leona's other medical problems are mild hypertension and chronic sacro-lumbar pain which appears to be attributable both to sciatic damage sustained in a water skiing accident 24 years ago and Shunerman's disease as teenager. Demonstrating both rheumatoid and osteoarthritis changes in her fingers, she has a mild nodular deformity at the terminal joints of the 3rd and 4th fingers on the left hand and fusiform swelling in the medial and distal joints of most of her fingers. Her thumbs were intermittently painful and swollen. She first took cetyl myristoleate in mid-January, 1997. There is now increased range of motion in all of the finger joints and visible reduction of the rheumatoid-like swelling. The nodular deformities have not changed noticeably. Her back problems demonstrated no improvement. Her sedimentation rate has run from 15 to 35, and is currently 16, with her ANA <1:360. Leona is now able to play the piano all she wants to without pain or swelling of her fingers. Joyce - She is a 42-year-old mother of three and a court reporter in good general health, suffering only from moderate hayfever in the spring. Recently Joyce developed a generalized stiffness and soreness in her fingers, which was worse on her right hand. The condition became so bad over a couple of weeks that she began making numerous mistakes in her court reporting and her speed was significantly reduced. She was diagnosed with tenosynovitis. Joyce shows no deformities of her hands associated with arthritis. She began a course of cetyl myristoleate during the last week of February and finished the last week of March 1997. She reports complete restoration of her dexterity with return of her normal accuracy and speed, along with elimination of the associated pain. Bob - He is a 67 year-old retired politician who suffered lumbar and pelvic fractures in WWII when his jeep struck a land mine. Over the years, these injuries produced increasing pain, which seriously affected routine daily activities like getting out of bed in the morning and his ability to play golf. X-rays demonstrate degenerative arthritic changes in the lumbar articulations and the right sacroiliac joint. At 6 feet tall and 185 pounds, he is otherwise in good health. Bob has been using anti-inflammatory drugs for over 20 years, including Voltaren, ibuprofen, Tylenol, and aspirin. He took a one-half course of 7.6 grams of cetyl myristoleate in September 1996. He experienced moderately severe inflammation (breakthrough pain) on day two which lasted for three days. On the 4th day, the pain began to subside and was completely gone by the 5th day. He has been virtually pain-free since and is very happy with the increased comfort with which he can begin each day. He can now comfortably walk the golf course whereas before he was limited to a golf cart. In February 1997, he perceived a slight return of his low back pain and decided to take another one-half course. He experienced no breakthrough pain this time and is currently pain-free. He has not taken any other medication for his back pain since taking cetyl myristoleate initially. Virginia - She is an 85 year-old lady who still works part-time at the family-owned business and cares for her husband who has cancer. Virginia was diagnosed ten years ago with diabetes, and elevated triglycerides and cholesterol. Overweight all her life, she is now stable at 265 pounds. She suffers from long-standing osteoarthritis in her knees and ankles, for which she was placed on cetyl myristoleate. No other agents have been used by her for arthritis except for non-steroidal anti-inflammatory drugs, both OTC and prescription. After about 7.6 grams of cetyl myristoleate, she was able to walk without limping or experiencing significant pain. About three months following the initial course, some pain returned, but she has retained what she estimates to be 50% improvement. She also has gallstones and a recurrent problem with gout, both of which have been symptom less since her cetyl myristoleate course. She evidently did not receive enough cetyl myristoleate for her body weight and will be given another course of 13.25 grams. Rose - Rose is a 46 year old mother of four who works as a legal secretary. She was diagnosed five years ago as having an atypical form of multiple sclerosis. She had MRI exams of the skull and spinal cord, which demonstrated several areas of non-specific degenerative changes in the brain with several " bright spots " in the cervical spinal cord. She had periodic visual aberrations as well as constant fatigue and fibromyalgia-like pains focused in her trapezius (bilaterally), and in her upper arms and legs below the knees. She also complained of burning sensations in her hands and feet. All of the symptoms worsened with elevated stress. There was no sign of pernicious anemia or diabetes. She was receiving chiropractic therapy. Joyce was started on numerous naturopathic therapies in March 1996 without significant benefit over an eight-month period. In November 1996, she started on cetyl myristoleate and indicated that she felt more fatigued for the first three days but that the pain in her upper back and extremities was completely gone. She further reported that the tingling/burning sensation in her feet and hands was also gone. Rose felt this was the most striking aspect of the treatment as those areas were the ones most constantly affected. This improvement lasted until she had to travel out of state to tend to her mother who was diagnosed with a rapidly advancing malignancy. Over the next three weeks, her symptoms began to reappear. After the death of her mother, she returned home in as bad shape as before first taking cetyl myristoleate. She decided that she wanted to take another half course of cetyl myristoleate, which completely duplicated the relief from the initial dosage with the exception that she feels slightly less relief from her tendencies to fatigue than she did after the first course. Rose will be taking another half course to see if she can improve her stamina. J.P. - He is a 60 year old male who has been a farmer his entire life. Diagnosed with rheumatoid arthritis 15 years ago, he has been on various pharmacologic protocols during that time. The most recent includes Plaquenil, methotrexate, and prednisone, with daily non-steroidal anti-inflammatory drug dosing. J.P. has fusiform swelling involving most of the joints of his fingers and moderate ulnar deviation of both hands. He suffered severe pain most of the time which limited the labor he could perform. He began cetyl myristoleate during the last week of February 1997, at which time he terminated his methotrexate and Plaquenil (not recommended except in consultation with a qualified physician). He has also reduced his prednisone from 15 milligrams per day to 5 mg, but he still maintains his NSAID dosing on a daily basis. J.P. experienced a mild increase in pain during the first four days of taking cetyl myristoleate, but since then he has been pain free and the swelling in his hands is reducing. J.P. will be monitored over the next month to determine his stability, with checking of his serum parameters by an MD. If he continues to remain symptom-free, his steroid and NSAID therapies will be terminated. J.P. does not smoke, eat chocolate, nor drink alcohol or caffeinated beverages. He was advised at the onset of his cetyl myristoleate dosage to avoid sugar. He is also taking Glucosaplex (a mix of glucosamines) and Lyprinol (fatty acid extract of green lipped mussel) as an additional natural anti-inflammatory agent. Optimizing the Effects of Cetyl Myristoleate Since the days of Paracelsus, physicians have been combining therapeutic agents for synergistic effects, or to achieve potentiation of several compounds. As powerful a nutrient as it is, the effects of cetyl myristoleate can be helped by combining it with other natural substances. Two or three grams daily of omega-3 fish oil or two tablespoons full of flaxseed oil during the month-long course of cetyl myristoleate can help its effects. This should be accompanied by 300-500 mg of Vitamin E daily. A minimum of 1,500 mg of glucosamine sulfate should be taken daily for at least three months to assist in rebuilding cartilage damaged by degenerative arthritis. In severe cases, three to six grams of glucosamine daily for one month and reduced to 1,500 mg daily for three months has been found to be very effective. Afterwards, a daily maintenance of 500 mg of glucosamine should be used for healthy cartilage. If stomach upset occurs, glucosamine should be taken with meals. Clinical experience has shown that glucosamine sulfate is far superior when compared to cartilage extracts, such as sea cucumber, hydrolyzed bovine cartilage, and shark cartilage. This is due to the increased absorption and utilization of glucosamine sulfate compared to these sources of chondroitin sulfates, which are very large molecules and difficult to digest. Animal and human studies have shown up to 98% absorption of glucosamine,10,11 compared to only 8% absorption of chondroitin sulfate. One of the reasons that glucosamine sulfate is more effective in rebuilding cartilage when compared to other sources of glucosamine, including the N-acetyl and hydrochloride forms, is that it provides bioavailable dietary sulfur. Sulfur helps provide the protein links necessary for cartilage matrix repair. Another source of sulfur is Methylsulfonylmethane (MSM), which has been used historically to treat a wide variety of conditions including allergies, emphysema, arthritis, gastrointestinal upset, and some vascular conditions. MSM is a metabolite of dimethylsulfoxide (DMSO) and provides many similar good effects. MSM is found in most natural unprocessed foods. Because of its volatility, MSM is lost when fresh food is cooked, processed, or stored. The richest source of MSM is mother's milk; consequently, very few nursing infants are deficient in dietary sulfur. As with any oil, cetyl myristoleate requires lipase to be digested. Lipases are pancreatic enzymes that play a key role in the digestion of fats and fat soluble vitamins. If lipase is absent or deficient, cetyl myristoleate will be poorly absorbed, if at all. As many arthritis patients are of the age when lipase production decreases, approximately 100 mg of lipase enzyme should be taken with each cetyl myristoleate capsule. In addition to taking lipase, cholecystectomy patients will need lecithin or ox bile extract to assure absorption. Diet can play a role in optimizing the benefits of cetyl myristoleate. Carbonated cola beverages and citrus juices may block the absorption of cetyl myristoleate and should be avoided on the days cetyl myristoleate is taken. Sugar intake should be minimized when taking cetyl myristoleate, and adding refined sugar to liquids like coffee and tea should be avoided altogether. Alcohol and caffeine intake should be very limited or eliminated altogether while combating arthritis and chronic inflammatory conditions. Reported Results Both osteoarthritis and rheumatoid arthritis sufferers report striking improvement with cetyl myristoleate. Numerous private correspondence describes decreased stiffness and pain, and increased flexibility and range of motion with cetyl myristoleate. Swelling and redness is reduced in rheumatoid arthritis. Writers describe other health benefits, including positive effect of cetyl myristoleate on emphysema, hepatitis, hypertension, diabetes, eczema, psoriasis, colds, allergies, low back pain, and headaches. These reported improvements in general health status are not surprising since each of these conditions could be associated with deficiency in the balance of EFA's. Like everything else, cetyl myristoleate does not work 100% of the time. Failure to work can be associated with failure to follow the dietary recommendations; failure to use lipase in conjunction with each capsule of cetyl myristoleate; failure to take a sufficient amount of cetyl myristoleate; failure of the liver to uptake and respond to the cetyl myristoleate; and, misdiagnosis in which the condition is not really an arthritis-type condition. Dosage Cetyl myristoleate is taken in a one-month course. A total dose of 12 to 15 grams appears to be indicated. This is usually enough for most people, but for osteoarthritis sufferers, the dose appears to be related to the number of sites in which cartilage has worn away. For example, a patient with osteoarthritis of the knees could expect 10 to 15 grams to be sufficient in most cases, while a patient with osteoarthritis of 5 or 6 spinal discs, both hips, and both knees may require an additional 5 to 10 grams, or even a full second course. Some of the patients treated by the author would likely have benefited even more from their cetyl myristoleate usage with the larger doses now recommended. Contraindications and Toxicity With the tens of thousands of people who have taken cetyl myristoleate there have been no confirmed reports of adverse side effects. In common with fish oils, it may produce some mild burping in some people which passes within an hour. There have been no reported interactions with other medications or natural substances, and other substances (except those mentioned above as diet considerations) do not interfere with cetyl myristoleate. While teratogenicity of cetyl myristoleate is probably the same as for EFA's, as a safety matter cetyl myristoleate should not be used by pregnant or lactating women until studies of cetyl myristoleate's effects on fetuses and infants have been done. As with any substance being added to the diet of anyone with asthma or a history of severe allergic reactions, caution is advised and cetyl myristoleate should be used in these cases under the direct supervision of a health care professional. Toxicity studies have been performed on cetyl myristoleate and the lack of toxicity is evident. Test results deemed cetyl myristoleate a non-toxic material in accordance with Federal regulations. Mega-doses were given to test animals with no ill effects. Necropsy of test animals showed no ill effects on their internal organs.13 The LD50 of cetyl myristoleate was not established, but it can be presumed to far exceed 10 grams per kilogram of body weight. References 1.. Dorland's Medical Dictionary, 25th Ed. 2.. Shils, Olson, and Shike. Modern Nutrition in Health and Disease. Lea & Febigen, 1994. Philadelphia, PA. p. 1480. 3.. Diehl, H. W. and Fletcher, H. G., A Simplified Preparation of 2-Deoxy-D-ribose Based on Treatment of a-D- Glucose Monohydrate with Solid Calcium Hydroxide, Archives of Biochemistry and Biophysics, Vol. 78, No. 2, Dec. 1958. 4.. , M.D., J., and Gaby, M.D., A, Nutrition and Healing, August, 1996, Vol.3, Issue 8, paraphrase from page 5. 5.. Private correspondence to H. W. Diehl, Rockville, Md. from Dr. Fay Wood, Univ. of Cal., Berkeley, 1969. 6.. Diehl, H. W. and May, E. L., Cetyl Myristoleate Isolated from Swiss Albino Mice: An Apparent Protective Agent against Adjuvant Arthritis in Rats. Jour. of Pharmaceutical Sciences, Vol. 83, No. 3, Mar, 94 pp296-299. 7.. Murray, M. T. Encyclopedia of Nutritional Supplements, Prima Publishing, Rocklin, CA 1996 p. 237. 8.. Sobel, D. and Klein, A. C.. Arthritis: What Works. St. s Press, New York, NY. pp. 221-225. 9.. Shils, Olson, and Shike. Ibid. pg. 550. 10.. Setnikar, I., et al., Pharmacokinetics of glucosamine in man. Arztneim Forsch 43 (10), 1109-1113, 1993. 11.. Setnikar, I., et al., Pharmacokinetics of glucosamine in the dog and man. Arztneim Forsch 36(4), 729-735, 1986. 12.. on, M., Therapeutic applications of chrondroitin-4-sulfate, appraisal of biologic properties. Folia Angiol 25, 225-232, 1977. 13.. Leberco Testing, Inc., Jan. 22, 1996, private correspondence to EHP Products, Inc. Reprinted with exclusive permission by Natrol, Inc. Cetyl Myristoleate (CMO) << back : 3 of 3 -------------------------------------------------------------------------------- [iN MEMORIAM | Testimonials for CetylPure and Cetyl Myristoleate ] [Our Customer Testimonials ] IN MEMORIAM Harry W. Diehl was born in 1910 in onburg, VA. Considered by many as one of the most brilliant natural talents in chemistry they have ever seen, Diehl retired in 1974 after 40 years of service at the National Institutes of Health in the Laboratory of Chemistry of the National Institute of Arthritis, Metabolic, and Digestive Diseases. He discovered cetyl myristoleate in 1964. Diehl was led to the discovery of cetyl myristoleate through his concern in 1953 about a neighbor's pain and disability from rheumatoid arthritis. Mr. Diehl pursued the scientific fact that mice do not get arthritis and discovered cetyl myristoleate through his exhaustive investigations and analysis. As he put it, " My discovery of cetyl myristoleate was a lot of hard work and a lot of old fashioned chemical cooking. " Diehl's research on cetyl myristoleate was published in the March 1994 issue of the American Journal of Pharmaceutical Sciences, the prestigious peer review journal of the American Pharmaceutical Association and the American Chemical Society. Diehl received two U.S. Patents on cetyl myristoleate, the first in 1977 for the treatment of rheumatoid arthritis and then in 1996 for osteoarthritis. An award winning researcher, Diehl developed over 500 new compounds, several of which were patented by the U.S. Patent Office. Diehl was recognized in 1958 for developing a new method of preparing 2-deoxy-d-ribose, a sugar found in deoxyribonucleic acid. This sugar is of vital importance to much basic research, and was used by Jonas Salk, M.D., as a culture medium to grow the Salk polio vaccine virus. Diehl's process was published in Biochemical Preparations, one of the most authoritative volumes on the subject. Harry Weldon Diehl died after a short illness in Charlottesville, Virginia on December 22, 1999 at the age of 89. In life, Harry Diehl was a tower of strength. He has left behind a legacy of hope. back to top TESTIMONIALS FOR CETYLPURET and CETYL MYRISTOLEATE The following are unsolicited letters to Natrol from users of CetylPureT and Cetyl Myristoleate August 28, 2000 To the CEO Natrol, Inc. Chatsworth, CA Sir, I could not let this opportunity pass by without informing you of what Cetyl Myristoleate has done in our lives. My husband Harry was diagnosed with Lumbar Radiculites and I with neuropathy/radicutopathy. His MRI revealed that he has Severe Degenerative Disease of the Lumbar Spine. For seven months he has been getting chiropractic care, pain medications, physical therapy, acupuncture, wearing the TENS unit including Duragesic patch. His daily activities were gone and he was confined to the home. His only relief was in bed or on the floor, hot and cold packs daily to his back, excruciating pain constantly. On July 10, I visited Nutrition Smart Health Food Store and received the booklet, " Arthritis and Cetyl Myristoleate " from Dr. Chuck Cochran. I explained to him our diagnosis and asked for his advise. He introduced this product to me and encouraged me to try it. With great eagerness I bought the product, took it home all excited about it to my husband. That same evening was our initial dose. Ten days after taking CetylPure, my husband woke up one morning with no pain in his leg. This continued for the day and subsequent days, he was pain free. Every one who knew of the pain that he had been having failed to believe that the pain just went. It has now been six weeks without pain. No more surgery as we were planning. Thanks for such a wonderful change in our lives, and for bringing CetylPure to our neighborhood store. It's a miracle and I thank God for Alternative Medicine and people like you and your staff. My question is this - " How long should we continue with the maintenance supplement? The store does not have the individual supplement bottle, and I do not want to be without it. Anticipating a favorable reply. We remain Sincerely yours, Gloria and Harry Whyte Miramar, FL April 27, 2000 To Whom it May Concern: I have been taking CetylPure for about 6 weeks now. I have severe arthritis in my upper arm and shoulder area due to a break several years ago. The arthritis has been so bad that I have been unable to lift my arm or extend it without a great deal of pain. The lack of use in my arm has caused me to turn down much needed work. I have taken prescriptions for anti-inflammatories but they are not good to take long term and can cause other organ damage. The CetylPure has helped me immensely. I have been able to go off my prescription and return to work. The use of my arm has returned about 85 to 95 percent. I think it is a very good product Sincerely, Mr. Liakos Simi Valley, CA April 26, 2000 To Whom It May Concern: In reference to your CetylPure product, I have been taking it for about a month now. The product really works for pain of arthritis in my hands. The swelling in my knuckles has improved as well. When I have missed the midday supplements on a few occasions, it was noticeable. When I continued taking the product, I felt it working again. I have less stiffness in my hands now. Mrs. F. Hacienda Heights, CA Reprinted with permission from Natrol, Inc. CMO Hi , My Mom is interested in CMO but doesn't want to get it thru the website because she is afraid she will started getting all sorts of junk e-mail..... Can you send me the info on it (price, 800 phone number, form of CMO and dosage)? Mom used to take a liquid form of CMO but it's no longer available. I am confused by Angel - I just saw where someone in Europe is named Angel. I thought it sounded like she was from Az..... Once again, will write more later. Thanks, Jody Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 1, 2009 Report Share Posted September 1, 2009 What is CMO that sme of you are taking with success for RA? Quote Link to comment Share on other sites More sharing options...
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