[Fwd: Re: Re: Question about Rx for 50 mg tablets]

[Guest guest]

It's not private anymore.

Is it possible that in Skip's email, when he refers to 'people who make their

own' he's also including those who add water to 50 mg tablets? Those 50 mg

tablets have fillers and I know Skip has an opinion on fillers. It appears you

made a leap from an email addressing cutting tablets up in correct doses

(which cracks me up immensely each time I read it...visualize 11.11 exact pieces

of a small tablet, no dust) to adding water and ignoring fillers.

>

> Skip Lenz sent me this email privately in response to a

> thread on splitting 50 mg tablets with any assurance of

> even distribution of drug. Due to the fact that in LDN we

> are dealing with a small amount of drug and trying to split

> a small tablet into ten or more pieces the margin of error

> is amplified.

>

> The best use of a 50 mg tablet is to dilute it in 50 ml of

> distilled water and shake before each dose is removed to

> insure complete and thorough distribution of drug in each dose.

>

> Thanks to Skip for providing this information!

>

> Garnet

>

> --- Re: [low dose naltrexone] Re: Question about Rx for

> 50 mg tablets

> Date: Mon, 8 Jun 2009 11:41:13 EDT

> From: SLenzrph@...

> garnet@...

>

>

> No, it was the result of a clinical study published several

> years ago

> that showed.

> 1. medicant distribution was not linear thruout a tablet.

> 2. cutting was not precise. Even for pharmacists equipped

> to tablet split.

>

>

> Yes I actually do know how a tableting machine works

> and the kinetic

> profile of powder flow thru. " Some tablets actually

> must be tested

> for distribution of drug. The range is +/- 5%. Lets

> say that you

> are making a 4.5mg dose but you got a low end tablet =

> 4.27mg. Now

> lets say that you are using a two ounce bottle to make

> it = 60mls.

> . So now you take 4.5 mls and you get 3.2mg. Gee I

> wonder why it

> doesn't work.

>

> Now if you split the tablet you are increasing error by an

> unknown

> factor. Maybe more, maybe less, who knows.

> There are many people who " make their own " . I have stopped

> arguing with

> them. They won't be part of our new survey though.

> Dr. Skip

>

>

>

>

>

>

> .

>

>

>

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