Guest guest Posted January 20, 2000 Report Share Posted January 20, 2000 Thanks, I hope so too, I have 2 doctor apt next week and some tests I hope all goes well.<br>sunflower Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 11, 2001 Report Share Posted August 11, 2001 Good luck with computer repair. Harper Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 30, 2003 Report Share Posted March 30, 2003 Dear Deedomwho, I echo your appreciation of EVERYONE who has posted a question, which helped many, who posted an answer which helped even more, and to all of you for making this site accurate and successful. I appreciate your display of appreciation. Respectfully, Jeanetta Mastron CPhT Founder/Owner > I just wanted to THANK EVERYONE for all the posts on this site. This > site has been my main source of information for preparing for this > exam. It has many dedicated people with resourceful information. > > The confidence that I have received for taking this exam has come > from this site. Please keep up the good work. THANK YOU so much. > > GOOD LUCK TO ALL this morning!!!!!!!!! > > DEEDOMWHO > > P.S. The butterflies in my stomach are giving " BIRTH " . LOL Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 7, 2004 Report Share Posted January 7, 2004 , Good luck on the 13th. I will keep you in my prayers. Kathy in CA Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 11, 2004 Report Share Posted January 11, 2004 Thanks . Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 16, 2004 Report Share Posted July 16, 2004 , I am sure you will do fine! Don't forget to relax! Jeanetta Tucker <3MAGIC3@...> wrote: To everyone who will be taking the exam tomorrow GOOD LUCK. A great big THANKS to everyone on this site for all the help. Between what I have learned in class & here, it has left me feeling confident that I will do well. San Diego Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 27, 2004 Report Share Posted September 27, 2004 > , Good luck tommorow. We are all thinking of you! > Can't wait to hear from you when you get back. > I know Dr Aceves and Nina will take good care of you. > > Maggie Hey Maggie gonna highjack your thread here and wish a fast and speedy recover to ! You know you and Bruno are the only guys here, so like you better treat us lady nice and that means sticking to that diet and working that band for all its worth!! HAHHAHA Hugs and best of luck! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2005 Report Share Posted November 19, 2005 thank you Amy! Good luck to all!!!! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 31, 2006 Report Share Posted October 31, 2006 the polymerase inhibitors show promise for being far superior to the interferon med currently in use. from what i've read awhile back theyre pretty much for sure the next generation of tx, basically just bogged down in the dragged out process of trials & approval. as i recall the effectiveness on all genotypes is much better, tx durations will be shorter, & nowhere near the sides & possible long term or permanent damage to the body. this is what i'm holding out for. trying alt med & clean living to hang in there (at least...might even make big improvements if not clear) until these new cures are available. if i don't get off the cigars all the HCV concerns will soon be trivia though. > good luck > > > greetings: > I'm not new to the post however this is my first time > posting,I hope that is will help some of us. > There are trails all over the country. > > Reported by Jules Levin > ICAAC, Sept 30, 2006, San Francisco > > Resistance Profile for 4'-Azido-Cytidine (R1479), Reveals Lack of > Cross Resistance with 2'-C-Methyl-Cytidine, Interferon-Alfa and > Ribavirin > > I. NAJERA, S. LE POGAM, W. JIANG, V. LEVEQUE, S. RAJYAGURU, H. MA, > H. KANG, S. JIANG, S. ALI, K. KLUMPP, D. SMITH, J. SYMONS, N. > CAMMACK; Roche Palo Alto LLC, Palo Alto, CA. > > At the 2006 ICAAC meeting just completed in San Francisco there was > encoraging data reported for several new orally administered HCV > drugs still in early development. HCV-796, MK-0608, and R1626 are 3 > polymerase inhibitors for HCV therapy. HCV-796 is just entered phase > II study in patients. R1626 is soon to enter phase II in patients. > And MK-0608 is still in preclinical but shows so far the most > potency although in animal studies. HCV-796 showed a 1.4 HCV viral > load log reduction in a 2 week monotherapy study in patients. R1626 > showed a 1.2 log reduction in a 2 week monotherapy study in > patients. MK-0608 showed from 4.6 to 5.7 log reductions in 6 > chimpanzees. This is very potent and is similar to viral load > reductions seen in patients with the HCV protease inhibitor VX-950. > In addition to these drugs, there are a number of others at various > stages of development. At ICAAC study data reported suggest these > HCV polymerase drugs may not be cross-resistant. Combination therapy > of these oral agents will be studied. > > Background: The HCV polymerase is an attractive target for the > development of new and HCV-specific antiviral compounds. 2'-C-Methyl- > Cytidine and 4'-Azido-Cytidine (R1479) are potent inhibitors of both > genotype 1b and genotype 1a-polymerase driven replicon replication. > The corresponding 5'-triphosphate derivatives are potent and > selective inhibitors of the recombinant genotype 1b and 1a HCV > polymerase mediated RNA synthesis. > > Methods: In this study, we used the HCV subgenomic replicon system > to select and characterize HCV variants with reduced susceptibility > to 2'-C-Methyl-Cytidine and to R1479 and investigated potential > cross resistance with Interferon-alfa and Ribavirin. > > Results: Characterization of resistant replicons to 2'-C-Methyl- > Cytidine identified S282T in the NS5B coding region as the mutation > conferring resistance to this compound, similar to results obtained > with other 2'-methylated nucleoside analogs. Mutations S96T and S96T > in combination with N142T were associated with low level resistance > to the nucleoside analog R1479. > > Conclusions: No cross resistance was observed between R1479 and 2'-C- > Me-Cytidine, Interferon alfa or Ribavirin. This data will allow the > optimization of new polymerase inhibitors and their use in > combination therapy. > > R1479 is a Potent Inhibitor of HCV RNA Replication Across Genotype > 1a and 1b Clinical Isolates > > I. NAJERA, S. LE POGAM, A. KOSAKA, S. HU, P. DIETRICH, S. JIANG, H. > KANG, A. SESHAADRI, J. SYMONS, J. USUKA, K. KLUMPP, N. CAMMACK; > Roche Palo Alto LLC, Palo Alto, CA. > > R1479 (4'-Azido-Cytidine) is a potent inhibitor of replication of > the laboratory optimized genotype 1b strain Con1 and genotype 1a > strain H77 replicons. HCV shows a high degree of genetic > heterogeneity. Selection of resistance could be facilitated by the > presence of minority drug resistant variants within the viral > quasispecies. The aim of the study was to understand whether the > inhibitory activity of HCV polymerase inhibitors and resistance > selection is affected by the HCV intrinsic genetic heterogeneity. > > The sensitivity of subgenomic HCV replicons encoding the NS5B from > 30 treatment naïve HCV clinical isolates to R1479 and to two non > nucleoside polymerase inhibitors (benzothiadiazine derivative NNI-1 > and thiophene-2-carboxylic acid derivative NNI-2) was determined. To > determine the frequency of mutations associated with resistance to > R1479 and to non-nucleoside inhibitors within the HCV quasispecies > from treatment naïve patients, clonal sequence analysis was > performed on 7 different clinical isolates and a total of 720 > individual full length HCV NS5B sequences were generated. > > This study showed that R1479 is a potent inhibitor of HCV > replication across 30 different genotype 1a and 1b clinical isolates > and that the in vitro selected R1479-resistance mutations were not > observed among the 720 NS5B polymerase variants. Mutations related > to resistance to the non-nucleoside inhibitors NNI-1 and to NNI-2 > were present as minority species in samples of treatment naïve > patients. > > The higher frequency of non nucleoside inhibitor resistance > mutations as compared to the absence of resistance mutations to the > nucleoside analog R1479 in the HCV quasispecies of treatment naïve > HCV patients suggests a potential for faster development of > clinically significant resistance for non-nucleosides NNI-1 and NNI- > 2 as compared to the nucleoside inhibitor R1479. > > > fred > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2009 Report Share Posted May 30, 2009 Thank you so much!!! You're so thoughtful..take care, laurenSent from my iPhoneOn May 30, 2009, at 3:58 PM, " Kirkaldie" <.Kirkaldie@...> wrote: , Sending you tons of luck and good wishes, see you on the other side of surgery! Colorado Springs Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2009 Report Share Posted May 30, 2009 , Be healthy and strong. I remembered you in my prayers last night. Lets compare notes when you are ready (and bored enough) to write again. -Dyann Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 30, 2009 Report Share Posted May 30, 2009 , hoping for the best and a speedy feeling better. Dyann said it right..."compare notes when you're ready & BORED enough"....that made me laugh! G Re: [ ] Good luck , Be healthy and strong. I remembered you in my prayers last night. Lets compare notes when you are ready (and bored enough) to write again. -Dyann Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 1, 2009 Report Share Posted June 1, 2009 Hi ,Thank you for sharing these thoughts with me...they're very helpful & true! take care,laurenFrom: redmarmie <vclark@...> Sent: Monday, June 1, 2009 9:59:09 AMSubject: [ ] Re: Good luck , When your struck with the "why did I opt for this surgery" doubts...remember quality of life, quality of life. Have a very successful surgery. Your in our thoughts and prayers. Don't worry about they kids, they are resilent, mine was six when I had revision and he took it well except for the lack of pig piles on Mom Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 10, 2009 Report Share Posted June 10, 2009 I`m sure your journey will be a great one and you certainly have a good positive attitude which will help! Quote Link to comment Share on other sites More sharing options...
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