Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new bi

June 1, 2009

Clin Vaccine Immunol. 2008 Dec;15(12):1868-77. Epub 2008 Oct 29.

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Antibodies against glucan, chitin, and Saccharomyces cerevisiae mannan as new

biomarkers of Candida albicans infection that complement tests based on C.

albicans mannan.

Sendid B, Dotan N, Nseir S, Savaux C, Vandewalle P, Standaert A, Zerimech F,

Guery BP, Dukler A, Colombel JF, Poulain D.

INSERM U799, Université Lille 2, Lille, France.

Antibodies against Saccharomyces cerevisiae mannan (ASCA) and antibodies against

synthetic disaccharide fragments of glucans (ALCA) and chitin (ACCA) are

biomarkers of Crohn's disease (CD). We previously showed that Candida albicans

infection generates ASCA. Here, we explored ALCA and ACCA as possible biomarkers

of invasive C. albicans infection (ICI). ASCA, ALCA, ACCA, and Candida mannan

antigen and antibody detection tests were performed on 69 sera obtained

sequentially from 18 patients with ICIs proven by blood culture, 59 sera from CD

patients, 47 sera from hospitalized subjects colonized by Candida species (CZ),

and 131 sera from healthy controls (HC). ASCA, ALCA, and ACCA levels in CD and

ICI patients were significantly different from those in CZ and HC subjects

(P<0.0001). In ICI patients, these levels increased as infection developed.

Using ASCA, ALCA, ACCA, and Platelia Candida tests, 100% of ICIs were detected,

with the kinetics of the antibody response depending on the patient during the

time course of infection. A large number of sera presented with more than three

positive tests. This is the first evidence that the detection of antibodies

against chitin and glucans has diagnostic value in fungal infections and that

these tests can complement more specific tests. Future trials are necessary to

assess the value of these tests in multiparametric analysis, as well as their

pathophysiological relevance.

Publication Types:

Research Support, Non-U.S. Gov't

PMID: 18971303 [PubMed - in process]

PMCID: PMC2593178 [Available on 2009/06/01]

Gee now where would one get a saccharomyces infection? Hep-B and of course

saccharomyces binds heavy metals.......

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