Guest guest Posted March 21, 2005 Report Share Posted March 21, 2005 Tammy. Below is a copy/paste that describes the role of Singulair pretty good. The med blocks leukotrienes. I started taking it last August and now question if I need nasal spray at all. Takes a couple days to build up in the body if you have a lot of congestion. My allergy tests didn't show anything but I recently stopped Singulair and made a list of things to stop based on "possible" reactions. Soon I'll stop taking Singulair again and start taking things one at a time to see what happens and hopefully pin down the cause. Right now my list includes aspirin, milk and alcohol. What I found interesting with milk is you can have a delayed reaction that won't show up on an allergy test. So I'll let my nose be the judge. Also, there's a difference between lactose intolerance and a milk allergy. I hope not..I love milk. Think there are tests available for delayed reaction stuff. I hope it's not aspirin either but I'm learning a lot from this board. in Arizona LEUKOTRIENE-RECEPTOR ANTAGONISTS e.g. montelukast sodium (Singulair) Leukotrienes are potent bronchoconstrictors and cause airway wall oedema, increasing mucus production. Leukotrienes also attract eosinophils into the tissues and amplify the inflammatory process. Leukotriene antagonists specifically inhibit the production or actions of the inflammatory mediators (leukotrienes C4 and D4). The precise role of these medications in asthma is still being determined. However, they are likely to be useful as preventive treatment in mild asthma as an alternative to low doses of inhaled corticosteroids (potency equivalent to about 400mcg of BDP (CFC)); they may allow the dose of corticosteroids to be reduced in moderate asthma; and they may help in stabilising people with more severe disease29. They are likely to be useful in specific subtypes of asthma such as aspirin-sensitive asthma and exercise-induced asthma. The response to treatment is variable. Montelukast is a once-daily tablet that is well tolerated in children and confers a modest benefit in frequent episodic or mild persistent asthma. It appears to be very effective in providing prolonged protection from exercise-induced asthma. The advantages of leukotriene receptor antagonists are that: they are oral medications taken once or twice a day they treat asthma via a completely different pathway to other currently available medications. They are preventive medications and do not provide immediate benefit for acute episodes of asthma. They are not as effective as inhaled LABAs as adjunctive therapy to ICS. Indications include: prevention of day and night-time symptoms treatment of aspirin-sensitive asthma patients prevention of exercise-induced bronchoconstriction as adjunctive therapy when ICS or LABAs are not tolerated. Note that therapy should normally be continued during acute exacerbations of asthma, and therapy should not be substituted abruptly for inhaled or oral corticosteroids. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 22, 2005 Report Share Posted March 22, 2005 In a message dated 3/22/2005 12:05:07 PM US Mountain Standard Time, tami@... writes: My headaches I am sure are due to constant inflamation in the frontal sinus area Your doctor can advise on that, but if antihistamines, antibiotics and sinus meds don't do much I don't see why any doctor wouldn't let you try it. You may have a leuketrine caused inflamation that's preventing sinuses from draining too. My allergy doctor gave me a weeks worth of samples before I had to fill the prescription. I noticed when I stopped Singulair for about a week that I was starting to get sinus headaches and major congestion again. Not cheap if you don't have good insurance. Off topic, I recently read an article that the big pharmas are all in early stages of developing products in a belief that leuketrines may be a significant factor behind heart desease inflammation too. Great results with mice so far. Since Singulair only blocks two of the leuketrines, no one's sure yet if it will apply or if another product is needed. They believe it will be as big as cholesterol meds if they can succeed in the years to come. My $.03 in Arizona. Sunny and 75. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 18, 2005 Report Share Posted August 18, 2005 In a message dated 8/18/2005 9:02:42 AM US Mountain Standard Time, avifisher@... writes: In my own personal experience and in conversations with an allergist, a child allergist and my ENT, as I understand it singulair is a waste of money unless you're a shareholder of the company that makes it. It's a waste of money only if it doesn't work. If it works, it's not a waste of money and alleviates constant rhinitis. It should be prescribed, if for no other reason than, to determine the cause (or one of the causes) of rhinitis/conjestion/polyps. If it works, you'll learn that you have a leukotrine problem. If you have a leukotrine problem, you can then begin asking the "why" questions. Questions like "if bad leukotrines are synthesized from saturated fats, why do I have the problem while so many others don't"? Then it starts to really get complicated. If it doesn't work, you'll have to keep searching for another question to ask but at least you will have learned something. Even though Singulair, if it works, only masks some other underlying problem, any doctor who refuses to prescribe it on the basis of their belief that "it's a waste of money" is one of the half of all doctors who graduated in the lower 50% of their class. If a doctor won't prescribe it, I'd walk out. If the stuff doesn't do anything, I'd stop taking it. If it does something good, I'd enjoy the moment. Just remember that if it works, it's a treatment, not a cure. (AZ) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 18, 2005 Report Share Posted August 18, 2005 well said ... tx / Avi > In a message dated 8/18/2005 9:02:42 AM US Mountain Standard Time, > avifisher@y... writes: > In my own personal experience and in conversations with an allergist, > a child allergist and my ENT, as I understand it singulair is a waste > of money unless you're a shareholder of the company that makes it. > It's a waste of money only if it doesn't work. If it works, it's not a waste > of money and alleviates constant rhinitis. It should be prescribed, if for > no other reason than, to determine the cause (or one of the causes) of > rhinitis/conjestion/polyps. If it works, you'll learn that you have a leukotrine > problem. If you have a leukotrine problem, you can then begin asking the " why " > questions. Questions like " if bad leukotrines are synthesized from saturated > fats, why do I have the problem while so many others don't " ? Then it starts to > really get complicated. If it doesn't work, you'll have to keep searching for > another question to ask but at least you will have learned something. > > Even though Singulair, if it works, only masks some other underlying problem, > any doctor who refuses to prescribe it on the basis of their belief that > " it's a waste of money " is one of the half of all doctors who graduated in the > lower 50% of their class. If a doctor won't prescribe it, I'd walk out. If the > stuff doesn't do anything, I'd stop taking it. If it does something good, I'd > enjoy the moment. Just remember that if it works, it's a treatment, not a > cure. > > (AZ) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2009 Report Share Posted April 5, 2009 No I am fine since I stopped taking it.Sent via BlackBerry from T-MobileFrom: Jane Marino Date: Sun, 29 Mar 2009 20:43:14 -0700 (PDT)<samters >Subject: Re: Re: Singulair Were you on any other medications at the time that could have caused those feelings?JaneFrom: gwenrafter@... <gwenrafter@...>Subject: Re: Re: Singulairsamters Date: Saturday, March 28, 2009, 8:54 PMI had to stop taking singulair. It made me have thoughts of suicide. After I stopped taking it I am fine and happy again. When I was on it I had this feeling of dispair/ From: Becca <rebeebit (DOT) com>samters@groups .comSent: Thursday, March 26, 2009 11:15:44 PMSubject: Re: Singulair,Your comment about Singulair affecting your mood (making you angry) was a huge red flag for me. I've been wondering if it makes me a little depressed and (sorry to get too personal) if it affects my sex drive. I have read a few studies of Singulair saying that these two mood side affects are possible. Anyone else notice that Singulair has changed their moods? I'm considering going off it altogether because I'm a little disturbed by my change in mood.I also have some questions for --how do you take the honey, and are there any counter-indications for the Fungal Defense product that you use? Since I don't know if I have a fungal problem, I don't know if I should take it.Cheers,Becca"Dogs have masters, while cats have staff."--unknown Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 Hi Dana, Would singulair normally results to mood swings and yeasty behaviours? If it does occur, do we continue with it for a few days more before we finally stop? What other replacements are available? Thanks. -richard- ________________________________ From: danasview <danasview@...> Sent: Tuesday, November 17, 2009 10:16:22 Subject: [ ] Re: OCD out of control > I thought OCD was a symptom of bacterial infection? It can be, especially strep bacteria. At my house, OCD was caused by viruses, yeast, and B12 deficiency. Dana How can I tell if my jewelry is real silver? Find Out on Answers. http://ph.answers./ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 > Hi Dana, > Would singulair normally results to mood swings and yeasty behaviours? Yes, it is common for Singulair to increase yeast. >>If it does occur, do we continue with it for a few days more before we finally stop? What other replacements are available? Depends on why you are using it. My own asthma was caused by yeast in my lungs, so when I felt an attack coming, I took GSE and the attack resolved relatively quickly. Taking daily biotin was helpful for me, and GSE when required. I eliminated my asthma with chelation and several supplements, including biotin. Dana Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 20, 2009 Report Share Posted November 20, 2009 If you research Singulair you will see that it has been linked to a couple of pre-teen suicides. I felt like it made my son mildly depressed/less joyful, in general. It worked great for controlling inflammation and he was on it for some time (around 6 months, I think) during the most acute phase of his healing process. We needed it in the beginning. But as things have improved I decided in the end that the risks out-weigh the benefits.  Pygnogenol is good at controlling allergic reactions. We have seen a difference with him on this. And I just read that Transfer Factor might also be helpful (specifically for kids who seem to be very over-reactive suggesting T1/T2 immune cell skewing... which is his issue most likely) so you might look into that also. Best wishes for improved health. From: stephanieweeks@... <stephanieweeks@...> Subject: [ ] Re: singulair Date: Friday, November 20, 2009, 2:04 AM  Singulair made my son very moody... > > I thought OCD was a symptom of bacterial infection? > > It can be, especially strep bacteria. > > At my house, OCD was caused by viruses, yeast, and B12 deficiency. > > Dana > > > > > > How can I tell if my jewelry is real silver? Find Out on Answers. http://ph.answers. / > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2010 Report Share Posted July 31, 2010 Is anyone using the Singulair spray rather than the powder on a child under 5 years of age? We have good results with the powder but it irritates the gut and are wondering if the spray is an option. We use it as a lieukotriene inhibitor not for asthma. Thank you Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2010 Report Share Posted July 31, 2010 Elena we had a lot of problems with singulair such as behaviour out of control Odysseas From: Elena Polyzos <etsadaris@...> Subject: Re: [ ] Singulair Date: Friday, July 30, 2010, 11:02 PM Is anyone using the Singulair spray rather than the powder on a child under 5 years of age? We have good results with the powder but it irritates the gut and are wondering if the spray is an option. We use it as a lieukotriene inhibitor not for asthma. Thank you Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2010 Report Share Posted July 31, 2010 Hi Odysseas  This is a copy of a post I sent to a mom on another forum regarding Singulair, so have copied it to you.  We have had good results with Singulair but it has been a bumpy road. It was prescribed by our daughter's gastroenterologist as a leukotriene inhibitor and we saw a jump in language and cognition when we started using it. However, just like the horror stories you read on the net, it immediately affected our daughter's sleep and behaviour adversely and also irritated her gut. I know some kids can tolerate Singulair with no problems -a friend's child is on 20mg a day and sleep through the night no problems. When I brought up this problem with Judy Converse the nutritionist, she explained that Singulair impacts serotonin chemistry, so if a child has low serotonin to begin with, then it will affect sleep and mood. Singulair works on mast cells which have both histamine and serotonin; as a mast cell inhibitor, Singulair depletes serotonin, so it would make a child very irritable, have difficulty sleeping, and be very negative. That's why so many people have problems with it. We use a low dose of Singulair and replenish serotonin with 5HTP (5-htp) and B group vitamins. This has solved the problem of sleep and mood. We are just about to try the spray to see if this is less irritating on the gut. Here is an article which explains how Singulair depletes serotonin Quote: >> Differential release of serotonin and histamine from mast cells > > > THEOHARIS C. THEOHARIDES, PHILIP K. BONDY*, NIKOLAOS D. TSAKALOS†& PHILIP W. ASKENASE > > Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA and *Veterans Administration Medical Center, West Spring Street, West Haven, Connecticut 06516, USA > †Permanent address: Department of Internal Medicine, Aristotelian University School of Medicine, Thessaloniki, Greece. > > Exocytosis dependent on calcium and metabolic energy has been established as the mechanism for the release of membrane-bound secretory products from various exocrine, endocrine and neural cells1. This has also been shown to be the case in mast cells, which have been used increasingly as a model secretory system2. The secretory granules of mast cells contain several mediators3, some of which, such as histamine, are known to participate in many immune reactions and allergic diseases4,5. Because of mast cell involvement in these clinical syndromes, as well as the role of histamine in gastric acid secretion6 and possibly in brain pathophysiology7, there has been great interest in the pharmacological modulation of histamine release from mast cells8. Serotonin is also stored in mast cell granules of several species but much less is known about its secretion. Because histamine and serotonin may have divergent functions in delayed hypersensitivity4,9, we hypothesized that these amines could undergo differential release. We now report that the tricyclic antidepressant drug amitriptyline (Elavil) inhibits histamine release from stimulated mast cells while permitting the release of serotonin. In these conditions, exocytosis of secretory granules is largely prevented, but serotonin is released by an unknown process which still requires calcium and metabolic energy. The ability to secrete differentially expands the physiological potential of the mast cell, and suggests that release of serotonin may not always indicate mast cell secretion via exocytosis of secretory granules. Hope this helps.  --- Στις Σάβ., 31/07/10, ο/η ODYSSEAS OMEROS <perimetrikos@...> ÎγÏαψε: Από: ODYSSEAS OMEROS <perimetrikos@...> ΘÎμα: Re: [ ] Singulair Î Ïος: ΗμεÏομηνία: Σάββατο, 31 ΙοÏλιος 2010, 6:04  Elena we had a lot of problems with singulair such as behaviour out of control Odysseas From: Elena Polyzos <etsadaris@...> Subject: Re: [ ] Singulair Date: Friday, July 30, 2010, 11:02 PM Is anyone using the Singulair spray rather than the powder on a child under 5 years of age? We have good results with the powder but it irritates the gut and are wondering if the spray is an option. We use it as a lieukotriene inhibitor not for asthma.  Thank you Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2010 Report Share Posted July 31, 2010 Never knew they had the spray! (Something I need to ask for) Leukatriene inhibitors keep allergies at bay so one does not have asthma or mast cell outbreaks. (We have both here.) They are used for immune dysfunction, basically (which is our underlying cause of asthma and mastocytosis in my family). Good stuff (except for the dyes and fillers in the pills, if any. <sigh> > > > Is anyone using the Singulair spray rather than the powder on a child under 5 years of age? We have good results with the powder but it irritates the gut and are wondering if the spray is an option. We use it as a lieukotriene inhibitor not for asthma. > > Thank you > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 31, 2010 Report Share Posted July 31, 2010 Is this an " off label " use for this medication? Here are a list of possible side effects: In pediatric patients 2 to 5 years of age receiving Singulair, the following events occurred with a frequency ≥2% and more frequently than in pediatric patients who received placebo, regardless of causality assessment: fever, cough, abdominal pain, diarrhea, headache, rhinorrhea, sinusitis, otitis, influenza, rash, ear pain, gastroenteritis, eczema, urticaria, varicella, pneumonia, dermatitis, and conjunctivitis. Haven Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 1, 2010 Report Share Posted August 1, 2010 No, that is their job. I noticed a topic blink for hypethyroidism. Singulair is not used to treat thyroid conditions. > > Is this an " off label " use for this medication? > > Here are a list of possible side effects: > > In pediatric patients 2 to 5 years of age receiving Singulair, the following > events occurred with a frequency ≥2% and more frequently than in pediatric > patients who received placebo, regardless of causality assessment: fever, > cough, abdominal pain, diarrhea, headache, rhinorrhea, sinusitis, otitis, > influenza, rash, ear pain, gastroenteritis, eczema, urticaria, varicella, > pneumonia, dermatitis, and conjunctivitis. > > Haven > > > Quote Link to comment Share on other sites More sharing options...
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