Guest guest Posted April 17, 2003 Report Share Posted April 17, 2003 : The study was in The recent edition of the New England Journal of Medicine. Here ya go (the abstract): Peacefully, Jeff Sell Hitt * * Sell 4309 Yoakum Boulevard 2nd Floor Houston, TX 77006 713.654.7776 713.654.7789 (fax) 832.731-3145 (v-mail) JZSell@... www.HittSell.com <http://www.HittSell.com> Previous Volume 348:1517-1526 April 17, 2003 Number 16 Next Intellectual Impairment in Children with Blood Lead Concentrations below 10 µg per Deciliter L. Canfield, Ph.D., R. , Jr., M.A., Deborah A. Cory-Slechta, Ph.D., , Ph.D., Todd A. Jusko, B.S., and Bruce P. Lanphear, M.D., M.P.H. Table of Contents Full Text of this article PDF of this article PDA version of this article Perspective Editor's Summary CME Exam Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive Download to Citation Manager Alert me when letters appear Alert me when this article is cited Articles in Medline by Author: Canfield, R. L. Lanphear, B. P. Child Health Neurologic Disease Related Chapters at on's Online ABSTRACT Background Despite dramatic declines in children's blood lead concentrations and a lowering of the Centers for Disease Control and Prevention's level of concern to 10 µg per deciliter (0.483 µmol per liter), little is known about children's neurobehavioral functioning at lead concentrations below this level. Methods We measured blood lead concentrations in 172 children at 6, 12, 18, 24, 36, 48, and 60 months of age and administered the Stanford-Binet Intelligence Scale at the ages of 3 and 5 years. The relation between IQ and blood lead concentration was estimated with the use of linear and nonlinear mixed models, with adjustment for maternal IQ, quality of the home environment, and other potential confounders. Results The blood lead concentration was inversely and significantly associated with IQ. In the linear model, each increase of 10 µg per deciliter in the lifetime average blood lead concentration was associated with a 4.6-point decrease in IQ (P=0.004), whereas for the subsample of 101 children whose maximal lead concentrations remained below 10 µg per deciliter, the change in IQ associated with a given change in lead concentration was greater. When estimated in a nonlinear model with the full sample, IQ declined by 7.4 points as lifetime average blood lead concentrations increased from 1 to 10 µg per deciliter. Conclusions Blood lead concentrations, even those below 10 µg per deciliter, are inversely associated with children's IQ scores at three and five years of age, and associated declines in IQ are greater at these concentrations than at higher concentrations. These findings suggest that more U.S. children may be adversely affected by environmental lead than previously estimated. Source Information From the Division of Nutritional Sciences (R.L.C.) and the Department of Human Development (C.R.H.), College of Human Ecology, Cornell University, Ithaca, N.Y.; the Departments of Environmental Medicine (D.A.C.-S.) and Biostatistics and Computational Biology (C.C.), University of Rochester School of Medicine, Rochester, N.Y.; the Division of Epidemiology, Statistics, and Prevention, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Md. (C.C.); the Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle (T.A.J.); and Cincinnati Children's Environmental Health Center, Children's Hospital Medical Center, Cincinnati (B.P.L.). Address reprint requests to Dr. Canfield at the Division of Nutritional Sciences, College of Human Ecology, Cornell University, Ithaca, NY 14853, or at rlc5@.... Blood lead levels Last night on the news they reported that a study was just done that showed there are NO safe levels of lead in the blood. It said that even a small amount can produce problems in the brain. Did anyone see that? I would like a copy of that to send to my insurance company who is fighting me on chelating my son's lead. Thanks! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2003 Report Share Posted April 17, 2003 : The study was in The recent edition of the New England Journal of Medicine. Here ya go (the abstract): Peacefully, Jeff Sell Hitt * * Sell 4309 Yoakum Boulevard 2nd Floor Houston, TX 77006 713.654.7776 713.654.7789 (fax) 832.731-3145 (v-mail) JZSell@... www.HittSell.com <http://www.HittSell.com> Previous Volume 348:1517-1526 April 17, 2003 Number 16 Next Intellectual Impairment in Children with Blood Lead Concentrations below 10 µg per Deciliter L. Canfield, Ph.D., R. , Jr., M.A., Deborah A. Cory-Slechta, Ph.D., , Ph.D., Todd A. Jusko, B.S., and Bruce P. Lanphear, M.D., M.P.H. Table of Contents Full Text of this article PDF of this article PDA version of this article Perspective Editor's Summary CME Exam Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive Download to Citation Manager Alert me when letters appear Alert me when this article is cited Articles in Medline by Author: Canfield, R. L. Lanphear, B. P. Child Health Neurologic Disease Related Chapters at on's Online ABSTRACT Background Despite dramatic declines in children's blood lead concentrations and a lowering of the Centers for Disease Control and Prevention's level of concern to 10 µg per deciliter (0.483 µmol per liter), little is known about children's neurobehavioral functioning at lead concentrations below this level. Methods We measured blood lead concentrations in 172 children at 6, 12, 18, 24, 36, 48, and 60 months of age and administered the Stanford-Binet Intelligence Scale at the ages of 3 and 5 years. The relation between IQ and blood lead concentration was estimated with the use of linear and nonlinear mixed models, with adjustment for maternal IQ, quality of the home environment, and other potential confounders. Results The blood lead concentration was inversely and significantly associated with IQ. In the linear model, each increase of 10 µg per deciliter in the lifetime average blood lead concentration was associated with a 4.6-point decrease in IQ (P=0.004), whereas for the subsample of 101 children whose maximal lead concentrations remained below 10 µg per deciliter, the change in IQ associated with a given change in lead concentration was greater. When estimated in a nonlinear model with the full sample, IQ declined by 7.4 points as lifetime average blood lead concentrations increased from 1 to 10 µg per deciliter. Conclusions Blood lead concentrations, even those below 10 µg per deciliter, are inversely associated with children's IQ scores at three and five years of age, and associated declines in IQ are greater at these concentrations than at higher concentrations. These findings suggest that more U.S. children may be adversely affected by environmental lead than previously estimated. Source Information From the Division of Nutritional Sciences (R.L.C.) and the Department of Human Development (C.R.H.), College of Human Ecology, Cornell University, Ithaca, N.Y.; the Departments of Environmental Medicine (D.A.C.-S.) and Biostatistics and Computational Biology (C.C.), University of Rochester School of Medicine, Rochester, N.Y.; the Division of Epidemiology, Statistics, and Prevention, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Md. (C.C.); the Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle (T.A.J.); and Cincinnati Children's Environmental Health Center, Children's Hospital Medical Center, Cincinnati (B.P.L.). Address reprint requests to Dr. Canfield at the Division of Nutritional Sciences, College of Human Ecology, Cornell University, Ithaca, NY 14853, or at rlc5@.... Blood lead levels Last night on the news they reported that a study was just done that showed there are NO safe levels of lead in the blood. It said that even a small amount can produce problems in the brain. Did anyone see that? I would like a copy of that to send to my insurance company who is fighting me on chelating my son's lead. Thanks! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 How long does a round of AC chelation affect the blood lead level? Does ALA affect the blood lead level at all? Or just the DMSA? I know that the DMSA will pull lead from the bones, but for how long does the lead remain circulating in the blood? Background: My daughter had her blood lead levels tested in August before starting kindergarten in September. Her level was a 4.9, meaning she's had exposure. When we brought her home from China 2 1/2 years earlier, her lead levels were only 2.2, so most of the exposure is from here, not from her life before joining our family. $400 later, and a lead assessment shows it's not my house. I've requested her preschool get checked, and they have some lead but almost all of it is covered by paint and should not be affecting the kids. My question: I was chelating her with both DMSA and ALA for her mercury toxicity before finding out that she had a more recent lead exposure. I need to get her rechecked to see if the lead is coming down since she's no longer in that school or if there is another exposure source that I'm unaware of. I don't want to throw off the blood test by doing a round of DMSA or ALA too close to when the blood draw is, so I need to know how long the lead will keep circulating before settling back into the bones/organs/etc. Thanks. Janelle Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 Was the 4.9 lead level test done after you starting doing rounds of chelation? If so....it isn't showing recent exposure at all but what she's dumping or releasing as a result of the chelation. The lead levels will go up and down as you chelate and as she dumps it. If you know there are no new exposures.....just continue chelation, since chelation for mercury and lead are done the same, there isn't any reason to stop because of having a lead problem vs mercury problem. Most kids numerous metals. Blood lead is indicative of previous three days exposure. Hair lead is three months. We use Hair lead done annually to see what is going on but it's not indicative of new exposures because we are chelating him. We didn't bother with blood lead because once chelation begins.....you can't rely on it for the purpose of current exposure and why stick him when we know he's got Lead, how much isn't that relevant. You don't need to recheck blood lead if you're going to chelate her anyway. Jan > > How long does a round of AC chelation affect the blood lead level? Does ALA affect the blood lead level at all? Or just the DMSA? I know that the DMSA will pull lead from the bones, but for how long does the lead remain circulating in the blood? > > Background: > My daughter had her blood lead levels tested in August before starting kindergarten in September. Her level was a 4.9, meaning she's had exposure. When we brought her home from China 2 1/2 years earlier, her lead levels were only 2.2, so most of the exposure is from here, not from her life before joining our family. $400 later, and a lead assessment shows it's not my house. I've requested her preschool get checked, and they have some lead but almost all of it is covered by paint and should not be affecting the kids. > > My question: I was chelating her with both DMSA and ALA for her mercury toxicity before finding out that she had a more recent lead exposure. I need to get her rechecked to see if the lead is coming down since she's no longer in that school or if there is another exposure source that I'm unaware of. I don't want to throw off the blood test by doing a round of DMSA or ALA too close to when the blood draw is, so I need to know how long the lead will keep circulating before settling back into the bones/organs/etc. > > Thanks. > Janelle > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 19, 2009 Report Share Posted November 19, 2009 Thanks Jan. The blood lead level was 23 days after ending her last round of chelation. We took a longer break between rounds than usual, so it was a long gap. I didn't think it'd affect her blood lead levels that long, but I also didn't want to make assumptions. So if I chelate her over the weekend, then I should wait until Thursday or Friday to get an accurate blood lead level because that would be three or more days after ending a round on a Monday morning? I want an accurate comparison to see if she's still getting an exposure somewhere else, and not a comparison based upon doing a round and pulling lead from her bones into her blood. The school's lead was pretty low, our home was free of lead, and so I want to know if something/somewhere else is contaminating my daughter because somehow she's showing more lead than she had three years ago, and this is after 30 rounds of chelation. Janelle <<Was the 4.9 lead level test done after you starting doing rounds of chelation? If so....it isn't showing recent exposure at all but <<what she's dumping or releasing as a result of the chelation. The lead levels will go up and down as you chelate and as she <<dumps it. << <<If you know there are no new exposures... ..just continue chelation, since chelation for mercury and lead are done the same, <<there isn't any reason to stop because of having a lead problem vs mercury problem. Most kids numerous metals. << <<Blood lead is indicative of previous three days exposure. Hair lead is three months. We use Hair lead done annually to see <<what is going on but it's not indicative of new exposures because we are chelating him. We didn't bother with blood lead <<because once chelation begins.....you can't rely on it for the purpose of current exposure and why stick him when we know he's <<got Lead, how much isn't that relevant. << <<You don't need to recheck blood lead if you're going to chelate her anyway. <<Jan Quote Link to comment Share on other sites More sharing options...
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