Re: delayed reaction/ 2 months later i have a problem sleeping

[Guest guest]

Here are a whole bunch more web sites that say the same thing, endorphins jack

you up and stimulate, making sleep difficult. If that is indeed the case, why is

the dosing required at night. I am beginning to see WAY more that a vocal

minority chime in about insomnia with nighttime dosing...

http://tinyurl.com/cojfbt

Carolyn Sunday

> > >

> > >

> > > I see what you're trying to compare by asking if someone reacts the

> > > opposite of an expected drug response.... but to keep this comparison

> > > relative [ 'apples to apples' ] -- I'd ask how someone reacts to

> > > higher levels of endorphins by OTHER means; ie; exercise, sex,

> > > acupuncture, etc Also, it's a hard comparison because I think the

> > > effects of LDN induced endorphins last longer than by OTHER means --

> > > something like up to 72hrs

> > >

> >

>

[Guest guest]

>

> Here are a whole bunch more web sites that say the same thing, endorphins jack

you up and stimulate, making sleep difficult. If that is indeed the case, why is

the dosing required at night. I am beginning to see WAY more that a vocal

minority chime in about insomnia with nighttime dosing...

Carolyn Sunday

===============

Answer.....

LDN induces a sharp increase in pituitary and adrenal production of

beta-endorphin and metenkephalin, respectively, in the pre-dawn(2am-4am) hours,

when 90% of the day's manufacture of these hormones occur. Most studies have

shown that low dose naltrexone induces a two to three-fold increase in

production of metenkephalin overnight. LDN only stays in the system 4 to 5

hours. Taken too early, say 5pm you miss the peak endorphin production, taken

at other times, like AM the endorphin boost may not be enough to halt your

disease progression if your disease is chronic progressive.

[Guest guest]

This post makes me wonder about the action of LDN, and its similarity to

endorphins created during exercise. No one denies the benefits of exercise-

every human disease and malady can benefit from some form. Is it possible that

LDN, by producing more endorphins, is similar to the effect of exercise? Just a

thought...

[Guest guest]

it is similar only much more and people that have been long time under

stress,chronic sick,mental stress will never be able to produce the amount of

endorphines needed.

>

> This post makes me wonder about the action of LDN, and its similarity to

endorphins created during exercise. No one denies the benefits of exercise-

every human disease and malady can benefit from some form. Is it possible that

LDN, by producing more endorphins, is similar to the effect of exercise? Just a

thought...

>

[Guest guest]

Carolyn,

From my understanding the bedtime dosing protocol was first suggested as a way

for patients to sleep through the mildly uncomfortable side effects of LDN. In

the case when sleep is disturbed and that condition does not resolve dosing at

another time of day seems better than not dosing at all.

Jaco

> From: sundaycarolyn <csunday@...>

> Subject: [low dose naltrexone] Re: delayed reaction/ 2 months later i have a

problem sleeping

> low dose naltrexone

> Date: Saturday, March 28, 2009, 3:22 AM

> Here are a whole bunch more web sites

> that say the same thing, endorphins jack you up and

> stimulate, making sleep difficult. If that is indeed the

> case, why is the dosing required at night. I am beginning to

> see WAY more that a vocal minority chime in about insomnia

> with nighttime dosing...

>

> http://tinyurl.com/cojfbt

>

> Carolyn Sunday

>

>

>

>

> > > >

> > > >

> > > > I see what you're trying to compare by

> asking if someone reacts the

> > > > opposite of an expected drug response....

> but to keep this comparison

> > > > relative [ 'apples to apples' ]

> --   I'd ask how someone reacts to

> > > > higher levels of endorphins by OTHER

> means;   ie;  exercise, sex,

> > > > acupuncture, etc    Also, it's a

> hard comparison because I think the

> > > > effects of LDN induced endorphins last

> longer than by OTHER means --

> > > > something like up to 72hrs

[Guest guest]

Well, taking LDN is NOT the same as going to the gym. It won't build muscle, if

that's what you mean. But the benefits of endorphin production

are definitely yours with LDN.

Jaco

> From: jwwisdom26 <jwwisdom26@...>

> Subject: [low dose naltrexone] Re: delayed reaction/ 2 months later i have a

problem sleeping

> low dose naltrexone

> Date: Saturday, March 28, 2009, 11:39 AM

> This post makes me wonder about the

> action of LDN, and its similarity to endorphins created

> during exercise. No one denies the benefits of exercise-

> every human disease and malady can benefit from some form.

> Is it possible that LDN, by producing more endorphins, is

> similar to the effect of exercise? Just a thought...

>

>

>

> ------------------------------------

>

>

[Guest guest]

Jaco, lots don’t have uncomfortable side effects, but I agree,

if people cannot tolerate night time dosing that is preferred according to Dr

Zagon (whom I’m fascinated with), Dr Bihari and Dr Lawrence then yes day

time dosing is better than none at all.

Best,

Jayne

Please sign the petition to the UK Govt to fund trials for LDN

http://petitions.number10.gov.uk/LowDNaltrexone/

From: low dose naltrexone

[mailto:low dose naltrexone ] On Behalf Of Jaco B

Sent: 28 March 2009 13:39

low dose naltrexone

Subject: Re: [low dose naltrexone] Re: delayed reaction/ 2 months later i

have a problem sleeping

Carolyn,

From my understanding the bedtime dosing protocol was first suggested as a way

for patients to sleep through the mildly uncomfortable side effects of LDN. In

the case when sleep is disturbed and that condition does not resolve dosing at

another time of day seems better than not dosing at all.

Jaco

> From: sundaycarolyn <csunday@...>

> Subject: [low dose naltrexone] Re: delayed reaction/ 2 months later i have a

problem sleeping

> low dose naltrexone

> Date: Saturday, March 28, 2009, 3:22 AM

> Here are a whole bunch more web sites

> that say the same thing, endorphins jack you up and

> stimulate, making sleep difficult. If that is indeed the

> case, why is the dosing required at night. I am beginning to

> see WAY more that a vocal minority chime in about insomnia

> with nighttime dosing...

>

> http://tinyurl.com/cojfbt

>

> Carolyn Sunday

>

>

>

>

> > > >

> > > >

> > > > I see what you're trying to compare by

> asking if someone reacts the

> > > > opposite of an expected drug response....

> but to keep this comparison

> > > > relative [ 'apples to apples' ]

> -- I'd ask how someone reacts to

> > > > higher levels of endorphins by OTHER

> means; ie; exercise, sex,

> > > > acupuncture, etc Also, it's a

> hard comparison because I think the

> > > > effects of LDN induced endorphins last

> longer than by OTHER means --

> > > > something like up to 72hrs

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[Guest guest]

Night time dosing has been the recommended advice since day one of this group

and it is what Dr. Bihari had/has MUCH success with. The explanation is clear.

Dr. Skip Lenz, Dr. Lawrence and Dr. McCandless supports it, too. The LDN website

states less than 2% of LDN users experience a sleep disturbance lasting longer

than 10 to 14 days. Sleep problems, if any, usually subside over time. Good

sleep habits/preparing for sleep is very important. I think to endure a few

difficult nights of sleeping in order to get the most *bang for your buck* to

control/conquer your health problem is worth it. To not even try is taking the

easy way out and if then LDN fails to work for you then it is unfair to blame it

for being ineffective.

Art

My MS/LDN Story 1988 -2009

http://preview.tinyurl.com/cv2gbu

--

> ===============

>

> Answer.....

> LDN induces a sharp increase in pituitary and adrenal production of

beta-endorphin and metenkephalin, respectively, in the pre-dawn(2am-4am) hours,

when 90% of the day's manufacture of these hormones occur. Most studies have

shown that low dose naltrexone induces a two to three-fold increase in

production of metenkephalin overnight. LDN only stays in the system 4 to 5

hours. Taken too early, say 5pm you miss the peak endorphin production, taken

at other times, like AM the endorphin boost may not be enough to halt your

disease progression if your disease is chronic progressive.

>

[Guest guest]

> Carolyn,

I got my info on time to take LDN and why directly from Dr. Bernard Bihari via

telephone.

[Guest guest]

To Art Hanson,

What is your vested interest in saying that only 2% of LDN users are

dosing in the day time? To my knowledge there have been no extensive

trails that verify that statement. No one asked me to respond to a poll

to that effect. I think it is unwise to tell people that only night time

dosing is effective. That may be the opinion of many people but it is by

no means an established fact. Dr. Zagon, the founder of LDN says that it

doesn't matter what time of day or night you take it. People should make

that decision themselves, based on their personal experience.

P. Fox

[Guest guest]

That is NOT what he said and his only " vested interest " is in seeing

most people following the protocol that has been most successful!

Julius or Perla Fox wrote:

> To Art Hanson,

>

> What is your vested interest in saying that only 2% of LDN users are

> dosing in the day time? To my knowledge there have been no extensive

> trails that verify that statement. No one asked me to respond to a poll

> to that effect. I think it is unwise to tell people that only night time

> dosing is effective. That may be the opinion of many people but it is by

> no means an established fact. Dr. Zagon, the founder of LDN says that it

> doesn't matter what time of day or night you take it. People should make

> that decision themselves, based on their personal experience.

>

> P. Fox

>

[Guest guest]

Hi Sherry,

I think some folks who do have sleep issues -- with or without LDN -- do take

sleeping pills. Some take melatonin. I've read where some just can NOT

tolerate sleeping pills...or melatonin.

And from MY perspective, why put another drug into your system when you don't

have to.

Best wishes,

Jann

[Guest guest]

Hi all,

For me now on Day13 I am clear that I am

willing to manage the wakefulness/disturbed sleep that I experience. Hiowever,

as I am experiencing significantly more pain during the night in particular, I

am struggling.

I have wondered if the two are connected –

if I didn’t wake up so much would I feel less pain and/or if I felt less

pain would I wake more and/ or id LDN causing both.

I am holding onto hope and pray that LDN

will be the breakthrough for me as my RA outlook is very bleak right now. Having

resisted Methotrexate and o0ther toxic drugs forced on me by consultants

andworked very hard to manage my health I cannot yet give up on the potential

answer in LDN.

So is there any common vie wof the link

between sleep disturbance and pain as an early response to LDN?

Nuala

From:

low dose naltrexone [mailto:low dose naltrexone ] On Behalf Of Art Hansen

Sent: 28 March 2009 17:07

low dose naltrexone

Subject: [low dose naltrexone] Re:

delayed reaction/ 2 months later i have a problem sleeping

Night time dosing has been the recommended advice

since day one of this group and it is what Dr. Bihari had/has MUCH success

with. The explanation is clear. Dr. Skip Lenz, Dr. Lawrence and Dr. McCandless

supports it, too. The LDN website states less than 2% of LDN users experience a

sleep disturbance lasting longer than 10 to 14 days. Sleep problems, if any,

usually subside over time. Good sleep habits/preparing for sleep is very

important. I think to endure a few difficult nights of sleeping in order to get

the most *bang for your buck* to control/conquer your health problem is worth

it. To not even try is taking the easy way out and if then LDN fails to work

for you then it is unfair to blame it for being ineffective.

Art

My MS/LDN Story 1988 -2009

http://preview.tinyurl.com/cv2gbu

--

> ===============

>

> Answer.....

> LDN induces a sharp increase in pituitary and adrenal production of

beta-endorphin and metenkephalin, respectively, in the pre-dawn(2am-4am)

hours, when 90% of the day's manufacture of these hormones occur. Most studies

have shown that low dose naltrexone induces a two to three-fold increase in

production of metenkephalin overnight. LDN only stays in the system 4 to 5

hours. Taken too early, say 5pm you miss the peak endorphin production, taken

at other times, like AM the endorphin boost may not be enough to halt your

disease progression if your disease is chronic progressive.

>